(Q37338875)

English

Morin (3,5,7,2',4'-Pentahydroxyflavone) abolishes nuclear factor-kappaB activation induced by various carcinogens and inflammatory stimuli, leading to suppression of nuclear factor-kappaB-regulated gene expression and up-regulation of apoptosis

scientific article published on April 2007

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scholarly article

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28 December 2019

Morin (3,5,7,2',4'-Pentahydroxyflavone) abolishes nuclear factor-kappaB activation induced by various carcinogens and inflammatory stimuli, leading to suppression of nuclear factor-kappaB-regulated gene expression and up-regulation of apoptosis (English)

1 reference

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28 December 2019

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apoptotic process

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based on heuristic

inferred from title

3

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28 December 2019

author name string

Sunil K Manna

1

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28 December 2019

Rishi S Aggarwal

2

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28 December 2019

Bharat B Aggarwal

4

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28 December 2019

Govindarajan T Ramesh

5

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28 December 2019

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1 April 2007

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28 December 2019

Clinical Cancer Research

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28 December 2019

13

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28 December 2019

7

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28 December 2019

2290-2297

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28 December 2019

describes a project that uses

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11 June 2022

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Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia

1 reference

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6 September 2017

Ethyl caffeate suppresses NF-kappaB activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2 in vitro or in mouse skin

1 reference

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6 September 2017

Nuclear factor-kappaB: the enemy within

1 reference

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6 September 2017

Activation of transcription factor NF-kappaB requires ELKS, an IkappaB kinase regulatory subunit

1 reference

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6 September 2017

Nuclear factor-kappaB: its role in health and disease

1 reference

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6 September 2017

TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway

1 reference

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6 September 2017

Missing pieces in the NF-kappaB puzzle

1 reference

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6 September 2017

The essential role of MEKK3 in TNF-induced NF-kappaB activation

1 reference

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6 September 2017

Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1.

1 reference

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6 September 2017

Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation

1 reference

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6 September 2017

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

1 reference

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6 September 2017

Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activation

1 reference

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6 September 2017

MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta

1 reference

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6 September 2017

NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

1 reference

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6 September 2017

Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B

1 reference

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6 September 2017

TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways

1 reference

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6 September 2017

Transcriptional roles of nuclear factor kappa B and nuclear factor-interleukin-6 in the tumor necrosis factor alpha-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells

1 reference

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6 September 2017

Inducible phosphorylation of I kappa B alpha is not sufficient for its dissociation from NF-kappa B and is inhibited by protease inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740379

6 September 2017

Studies into the effect of the tyrosine kinase inhibitor herbimycin A on NF-kappa B activation in T lymphocytes. Evidence for covalent modification of the p50 subunit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740379

6 September 2017

Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemot

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740379

14 September 2017

Suberoylanilide hydroxamic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing nuclear factor-kappaB activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740379

14 September 2017

Morin inhibits 12-O-tetradecanoylphorbol-13-acetate-induced hepatocellular transformation via activator protein 1 signaling pathway and cell cycle progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740379

14 September 2017

Luteolin sensitizes tumor necrosis factor-alpha-induced apoptosis in human tumor cells.

1 reference

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14 September 2017

Flavone inhibition of tumor growth via apoptosis in vitro and in vivo.

1 reference

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14 September 2017

Morin sulfates/glucuronides exert anti-inflammatory activity on activated macrophages and decreased the incidence of septic shock.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740379

14 September 2017

Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740379

14 September 2017

Betulinic acid suppresses carcinogen-induced NF-kappa B activation through inhibition of I kappa B alpha kinase and p65 phosphorylation: abrogation of cyclooxygenase-2 and matrix metalloprotease-9.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740379

14 September 2017

The PTEN tumor suppressor protein inhibits tumor necrosis factor-induced nuclear factor kappa B activity

1 reference

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28 September 2017

Assay for redox-sensitive transcription factor

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Protein tyrosine kinase inhibitors block tumor necrosis factor-induced activation of nuclear factor-kappaB, degradation of IkappaBalpha, nuclear translocation of p65, and subsequent gene expression

1 reference

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28 September 2017

Enhanced sensitivity of human oral tumours to the flavonol, morin, during cancer progression: involvement of the Akt and stress kinase pathways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740379

26 June 2018

Chemopreventive effect of dietary flavonoid morin on chemically induced rat tongue carcinogenesis

1 reference

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26 June 2018

Distinct signal transduction pathways mediate nuclear factor-kappaB induction by IL-1beta in epithelial and lymphoid cells

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Interaction of flavonoids with 1,1-diphenyl-2-picrylhydrazyl free radical, liposomal membranes and soybean lipoxygenase-1.

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Functional diversity of flavonoids in the inhibition of the proinflammatory NF-kappaB, IRF, and Akt signaling pathways in murine intestinal epithelial cells.

1 reference

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2 September 2018

A 13-week subchronic toxicity study of dietary administered morin in F344 rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740379

2 September 2018

Flavonols inhibit proinflammatory mediator release, intracellular calcium ion levels and protein kinase C theta phosphorylation in human mast cells

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2 September 2018

Flavonoids inhibit tumor necrosis factor-alpha-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-kappaB: structure-activity relationships

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Comparative study of flavonoids in experimental models of inflammation

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2 September 2018

Hydrogen peroxide activates NF-kappa B through tyrosine phosphorylation of I kappa B alpha and serine phosphorylation of p65: evidence for the involvement of I kappa B alpha kinase and Syk protein-tyrosine kinase

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2 September 2018

Inhibition of peroxisome proliferator-activated receptor (PPAR)-mediated keratinocyte differentiation by lipoxygenase inhibitors

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2 September 2018

Synthesis and tumoricidal activity evaluation of new morin and quercetin sulfonic derivatives

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2 September 2018

Inhibition of P-glycoprotein by flavonoid derivatives in adriamycin-resistant human myelogenous leukemia (K562/ADM) cells

1 reference

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2 September 2018

Intestinal anti-inflammatory activity of morin on chronic experimental colitis in the rat.

1 reference

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2 September 2018

Differential IκB Kinase Activation and IκBα Degradation by Interleukin-1β and Tumor Necrosis Factor-α in Human U937 Monocytic Cells

1 reference

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12 December 2020

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inferred from PubMed ID database lookup

Constitutive activation of NF-kappaB causes resistance to apoptosis in human cutaneous T cell lymphoma HuT-78 cells. Autocrine role of tumor necrosis factor and reactive oxygen intermediates

1 reference

https://pubmed.ncbi.nlm.nih.gov/17404114

12 December 2020

based on heuristic

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Growth-inhibitory effect of quercetin and presence of type-II estrogen-binding sites in human colon-cancer cell lines and primary colorectal tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/17404114

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of morin on an experimental model of acute colitis in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17404114

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-inflammatory actions of flavonoids and structural requirements for new design

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of azoxymethane-induced aberrant crypt foci in rats by natural compounds, caffeine, quercetin and morin

1 reference

https://pubmed.ncbi.nlm.nih.gov/17404114

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/1078-0432.CCR-06-2394

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17404114%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17404114%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17404114%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

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