(Q37376021)

20 August 2017

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title

The different faces of Notch in T-helper-cell differentiation (English)

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20 August 2017

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3

Richard A Flavell

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20 August 2017

Derk Amsen

1

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PubMed ID

19165228

20 August 2017

Andrey Antov

series ordinal

2

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20 August 2017

1 February 2009

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Nature Reviews Immunology

20 August 2017

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20 August 2017

9

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20 August 2017

2

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20 August 2017

116-124

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IL-17 family cytokines and the expanding diversity of effector T cell lineages

20 August 2017

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Functional diversity of helper T lymphocytes

31 March 2020

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Induction and effector functions of T(H)17 cells.

31 March 2020

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Dendritic-cell control of pathogen-driven T-cell polarization

31 March 2020

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IL-12 is dispensable for innate and adaptive immunity against low doses of Listeria monocytogenes

31 March 2020

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A signal transducer and activator of transcription (Stat)4-independent pathway for the development of T helper type 1 cells

31 March 2020

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IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses

31 March 2020

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Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

31 March 2020

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In the absence of IL-12, CD4(+) T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10(-/-) setting

31 March 2020

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Role of T-bet in commitment of TH1 cells before IL-12-dependent selection.

31 March 2020

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Host-dependent type 1 cytokine responses driven by inactivated viruses may fail to default in the absence of IL-12 or IFN-alpha/beta

31 March 2020

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Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene

31 March 2020

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Essential role of Stat6 in IL-4 signalling

31 March 2020

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Stat6 regulation of in vivo IL-4 responses

31 March 2020

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Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4+ lymphocytes with a Th2 cytokine profile

31 March 2020

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Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system

31 March 2020

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Accumulation of effector CD4 T cells during type 2 immune responses is negatively regulated by Stat6.

31 March 2020

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Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4+ T cell populations lacking helper function

31 March 2020

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Notch signalling: a simple pathway becomes complex

31 March 2020

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Notch signaling: cell fate control and signal integration in development

31 March 2020

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Notch signaling augments T cell responsiveness by enhancing CD25 expression

31 March 2020

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Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells

31 March 2020

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Functional conservation of mouse Notch receptor family members

31 March 2020

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Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability

31 March 2020

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Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2

31 March 2020

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Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation

31 March 2020

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Regulation of dendritic-cell differentiation by bone marrow stroma via different Notch ligands

31 March 2020

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The many facets of Notch ligands

31 March 2020

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Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells

31 March 2020

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CD8- DCs induce IL-12-independent Th1 differentiation through Delta 4 Notch-like ligand in response to bacterial LPS

31 March 2020

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MyD88-mediated instructive signals in dendritic cells regulate pulmonary immune responses during respiratory virus infection

31 March 2020

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Suppression of Th2 cell development by Notch ligands Delta1 and Delta4

31 March 2020

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Acinetobacter lwoffii and Lactococcus lactis strains isolated from farm cowsheds possess strong allergy-protective properties

31 March 2020

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Delta1-Notch3 interactions bias the functional differentiation of activated CD4+ T cells

31 March 2020

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JAGGED1 and delta1 differentially regulate the outcome of experimental autoimmune encephalomyelitis

31 March 2020

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Essential role of Notch signaling in effector memory CD8+ T cell-mediated airway hyperresponsiveness and inflammation.

31 March 2020

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Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch

31 March 2020

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Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition

31 March 2020

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Intramembrane proteolysis: theme and variations.

31 March 2020

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Notch signaling is an important regulator of type 2 immunity.

31 March 2020

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Notch directly regulates Gata3 expression during T helper 2 cell differentiation

31 March 2020

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Off the beaten pathway: the complex cross talk between Notch and NF-kappaB

31 March 2020

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NF-kappaB2 is a putative target gene of activated Notch-1 via RBP-Jkappa

31 March 2020

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Notch-1 regulates NF-kappaB activity in hemopoietic progenitor cells

31 March 2020

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Notch-1 associates with IKKalpha and regulates IKK activity in cervical cancer cells.

31 March 2020

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Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia.

31 March 2020

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Notch3 and pre-TCR interaction unveils distinct NF-kappaB pathways in T-cell development and leukemia.

31 March 2020

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Notch1 augments NF-kappaB activity by facilitating its nuclear retention

31 March 2020

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Specificity of sn50 for NF-kappa B?

31 March 2020

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A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation

31 March 2020

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Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling

31 March 2020

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A notch-independent activity of suppressor of hairless is required for normal mechanoreceptor physiology

31 March 2020

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Mastermind-like transcriptional co-activators: emerging roles in regulating cross talk among multiple signaling pathways.

31 March 2020

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Th2 differentiation is unaffected by Jagged2 expression on dendritic cells

31 March 2020

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Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthma

31 March 2020

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Human immature myeloid dendritic cells trigger a TH2-polarizing program via Jagged-1/Notch interaction

31 March 2020

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Endotoxin can induce MyD88-deficient dendritic cells to support T(h)2 cell differentiation

31 March 2020

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Toll-like receptors control activation of adaptive immune responses

31 March 2020

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Dendritic cell expression of the Notch ligandjagged2 is not essential for Th2 response inductionin vivo

31 March 2020

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NB-3/Notch1 pathway via Deltex1 promotes neural progenitor cell differentiation into oligodendrocytes.

31 March 2020

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F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation

31 March 2020

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The interleukin-4 enhancer CNS-2 is regulated by Notch signals and controls initial expression in NKT cells and memory-type CD4 T cells.

31 March 2020

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Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment.

31 March 2020

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Cutting edge: Identification of an alternative GATA-3 promoter directing tissue-specific gene expression in mouse and human

31 March 2020

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A 3' enhancer in the IL-4 gene regulates cytokine production by Th2 cells and mast cells

31 March 2020

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Expression of activated Notch3 in transgenic mice enhances generation of T regulatory cells and protects against experimental autoimmune diabetes

31 March 2020

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Notch3 inhibition in myelin-reactive T cells down-regulates protein kinase C theta and attenuates experimental autoimmune encephalomyelitis

31 March 2020

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Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset.

31 March 2020

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IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells

31 March 2020

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T follicular helper (TFH) cells in normal and dysregulated immune responses

31 March 2020

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Induction of antigen-specific regulatory T cells following overexpression of a Notch ligand by human B lymphocytes

31 March 2020

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Overexpression of the Notch ligand, Jagged-1, induces alloantigen-specific human regulatory T cells

31 March 2020

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Serrate1-induced notch signalling regulates the decision between immunity and tolerance made by peripheral CD4(+) T cells

31 March 2020

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Jagged2-expressing hematopoietic progenitors promote regulatory T cell expansion in the periphery through notch signaling

31 March 2020

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Notch regulates IL-10 production by T helper 1 cells

31 March 2020

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Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection.

31 March 2020

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CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis

31 March 2020

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Notch 1 signaling regulates peripheral T cell activation

31 March 2020

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Treg-mediated immunosuppression involves activation of the Notch-HES1 axis by membrane-bound TGF-beta

31 March 2020

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TCR-mediated Notch signaling regulates proliferation and IFN-gamma production in peripheral T cells

31 March 2020

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Turning it up a Notch: cross-talk between TGF beta and Notch signaling

31 March 2020

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Notch1 and TGFbeta1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells

31 March 2020

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Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice

31 March 2020

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Notch ligand Delta-like 4 regulates disease pathogenesis during respiratory viral infections by modulating Th2 cytokines

31 March 2020

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Mice lacking IL-12 develop polarized Th1 cells during viral infection

31 March 2020

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12 December 2020

Pancreas-infiltrating Th1 cells and diabetes develop in IL-12-deficient nonobese diabetic mice

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12 December 2020

Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21

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12 December 2020

IL-12 is not required for induction of type 1 cytokine responses in viral infections

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12 December 2020

Feedback regulation is central to Delta-Notch signalling required for Drosophila wing vein morphogenesis.

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12 December 2020

Identifiers

DOI

10.1038/NRI2488

1 reference

20 August 2017

1 reference

PubMed ID

19165228