(Q37384293)

English

Randomized, Double-Blind, Phase II Study of Ruxolitinib or Placebo in Combination With Capecitabine in Patients With Metastatic Pancreatic Cancer for Whom Therapy With Gemcitabine Has Failed.

scientific article published on 08 September 2015

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26351344%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

Randomized, Double-Blind, Phase II Study of Ruxolitinib or Placebo in Combination With Capecitabine in Patients With Metastatic Pancreatic Cancer for Whom Therapy With Gemcitabine Has Failed (English)

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23 February 2020

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1 reference

based on heuristic

inferred from title

pancreatic cancer

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

2

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26351344%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

author name string

Herbert I Hurwitz

1

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23 February 2020

Stephanie A Wagner

3

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23 February 2020

Johanna C Bendell

4

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23 February 2020

J Thaddeus Beck

5

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23 February 2020

Seaborn M Wade

6

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23 February 2020

John J Nemunaitis

7

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23 February 2020

Philip J Stella

8

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23 February 2020

J Marc Pipas

9

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23 February 2020

Zev A Wainberg

10

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23 February 2020

Robert Manges

11

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23 February 2020

William M Garrett

12

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23 February 2020

Deborah S Hunter

13

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23 February 2020

Jason Clark

14

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23 February 2020

Lance Leopold

15

1 reference

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23 February 2020

Victor Sandor

16

1 reference

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23 February 2020

Richard S Levy

17

1 reference

Europe PubMed Central

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23 February 2020

language of work or name

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publication date

8 September 2015

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23 February 2020

Journal of Clinical Oncology

1 reference

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23 February 2020

33

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23 February 2020

34

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Europe PubMed Central

PMC publication ID

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23 February 2020

4039-4047

1 reference

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PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26351344%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

Cancer-related inflammation and treatment effectiveness

1 reference

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6 September 2017

The role of inflammation in inflammatory breast cancer.

1 reference

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6 September 2017

STAT6 and lung inflammation

1 reference

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6 September 2017

Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms

1 reference

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6 September 2017

Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine

1 reference

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6 September 2017

Prognostic and predictive blood-based biomarkers in patients with advanced pancreatic cancer: results from CALGB80303 (Alliance)

1 reference

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6 September 2017

The regulation of inflammation by interferons and their STATs

1 reference

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6 September 2017

Inflammation and prostate cancer: the role of interleukin 6 (IL-6).

1 reference

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6 September 2017

The systemic inflammatory response and its relationship to pain and other symptoms in advanced cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5089161

6 September 2017

The immune network in pancreatic cancer development and progression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5089161

6 September 2017

The IL-6/JAK/Stat3 feed-forward loop drives tumorigenesis and metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5089161

6 September 2017

Second-line treatment in advanced pancreatic cancer: a comprehensive analysis of published clinical trials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5089161

6 September 2017

JAKs and STATs in immunity, immunodeficiency, and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5089161

6 September 2017

Understanding the mechanisms and treatment options in cancer cachexia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5089161

6 September 2017

Pancreatic adenocarcinoma: ESMO-ESDO Clinical Practice Guidelines for diagnosis, treatment and follow-up

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5089161

6 September 2017

The systemic inflammation-based Glasgow Prognostic Score: a decade of experience in patients with cancer.

1 reference

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6 September 2017

Does interleukin-6 link explain the link between tumour necrosis, local and systemic inflammatory responses and outcome in patients with colorectal cancer?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5089161

6 September 2017

Targeting Stat3 abrogates EGFR inhibitor resistance in cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5089161

6 September 2017

Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5089161

6 September 2017

JAK/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5089161

6 September 2017

A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5089161

6 September 2017

JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5089161

6 September 2017

Targeting the interleukin-6/Jak/stat pathway in human malignancies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5089161

6 September 2017

Constitutive AP-1 activity and EBV infection induce PD-L1 in Hodgkin lymphomas and posttransplant lymphoproliferative disorders: implications for targeted therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5089161

6 September 2017

Prognostic role of C-reactive protein in breast cancer: a systematic review and meta-analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5089161

6 September 2017

Elevated C-reactive protein in the diagnosis, prognosis, and cause of cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5089161

6 September 2017

STAT3 knockdown reduces pancreatic cancer cell invasiveness and matrix metalloproteinase-7 expression in nude mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5089161

6 September 2017

Best supportive care (BSC) versus oxaliplatin, folinic acid and 5-fluorouracil (OFF) plus BSC in patients for second-line advanced pancreatic cancer: a phase III-study from the German CONKO-study group

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5089161

6 September 2017

Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5089161

6 September 2017

Hallmarks of Cancer: The Next Generation

1 reference

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6 September 2017

Janus kinase inhibitors for the treatment of myeloproliferative neoplasias and beyond

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5089161

6 September 2017

Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5089161

6 September 2017

TGF-beta IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer

1 reference

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6 September 2017

STATs in cancer inflammation and immunity: a leading role for STAT3

1 reference

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6 September 2017

IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer

1 reference

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6 September 2017

New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)

1 reference

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6 September 2017

Receptor trafficking controls weak signal delivery: a strategy used by c-Met for STAT3 nuclear accumulation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5089161

6 September 2017

An inflammation-based prognostic score and its role in the nutrition-based management of patients with cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5089161

6 September 2017

Definition of cancer cachexia: effect of weight loss, reduced food intake, and systemic inflammation on functional status and prognosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5089161

6 September 2017

Signal transducer and activator of transcription 3 is required for the oncogenic effects of non-small-cell lung cancer-associated mutations of the epidermal growth factor receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5089161

6 September 2017

Pancreatic cancer: diagnosis and management.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5089161

6 September 2017

Stat3 regulates genes common to both wound healing and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5089161

6 September 2017

Role of STATs as downstream signal transducers in Src family kinase-mediated tumorigenesis

1 reference

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6 September 2017

Pancreatic cancer as a model: inflammatory mediators, acute-phase response, and cancer cachexia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5089161

6 September 2017

The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5089161

6 September 2017

STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis.

1 reference

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6 September 2017

In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses

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14 September 2017

Inhibition of STAT3 Tyr705 phosphorylation by Smad4 suppresses transforming growth factor beta-mediated invasion and metastasis in pancreatic cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5089161

14 September 2017

Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5089161

14 September 2017

Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways

1 reference

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14 September 2017

Erythropoietin-mediated activation of JAK-STAT signaling contributes to cellular invasion in head and neck squamous cell carcinoma

1 reference

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14 September 2017

Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration.

1 reference

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26 June 2018

Induction of Bv8 expression by granulocyte colony-stimulating factor in CD11b+Gr1+ cells: key role of Stat3 signaling.

1 reference

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26 June 2018

C-reactive protein and cholesterol are equally strong predictors of cardiovascular risk and both are important for quality clinical care

1 reference

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2 September 2018

National failure to operate on early stage pancreatic cancer.

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2 September 2018

Prognostic factors in patients with gemcitabine-refractory pancreatic cancer

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2 September 2018

Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling.

1 reference

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2 September 2018

Activated signal transducer and activator of transcription 3 (STAT3) supports the malignant phenotype of human pancreatic cancer.

1 reference

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2 September 2018

Measurement of the systemic inflammatory response predicts cancer-specific and non-cancer survival in patients with cancer.

1 reference

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2 September 2018

Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/26351344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26351344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of an inflammation-based prognostic score (GPS) in patients undergoing resection for colon and rectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/26351344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A comparison of inflammation-based prognostic scores in patients with cancer. A Glasgow Inflammation Outcome Study

1 reference

https://pubmed.ncbi.nlm.nih.gov/26351344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1200/JCO.2015.61.4578

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26351344%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26351344%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26351344%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

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