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Intramembrane-cleaving proteases
scientific article published on 03 February 2009
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scholarly article
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Europe PubMed Central
PMCID
2682844
retrieved
20 August 2017
review article
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Europe PubMed Central
title
Intramembrane-cleaving proteases
(English)
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Europe PubMed Central
PMCID
2682844
retrieved
20 August 2017
author name string
Michael S Wolfe
series ordinal
1
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Europe PubMed Central
PMCID
2682844
retrieved
20 August 2017
language of work or name
English
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publication date
3 February 2009
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Europe PubMed Central
PMCID
2682844
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20 August 2017
published in
Journal of Biological Chemistry
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Europe PubMed Central
PMCID
2682844
retrieved
20 August 2017
volume
284
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Europe PubMed Central
PMCID
2682844
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20 August 2017
issue
21
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Europe PubMed Central
PMCID
2682844
retrieved
20 August 2017
page(s)
13969-13973
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Europe PubMed Central
PMCID
2682844
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20 August 2017
cites work
Intramembrane proteolysis by signal peptide peptidases: a comparative discussion of GXGD-type aspartyl proteases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
6 September 2017
Substrate specificity of gamma-secretase and other intramembrane proteases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
6 September 2017
Structure of a site-2 protease family intramembrane metalloprotease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
6 September 2017
Active gamma-secretase complexes contain only one of each component
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
6 September 2017
Enzymatic analysis of a rhomboid intramembrane protease implicates transmembrane helix 5 as the lateral substrate gate
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
6 September 2017
Open-cap conformation of intramembrane protease GlpG
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
6 September 2017
Rhomboid protease AarA mediates quorum-sensing in Providencia stuartii by activating TatA of the twin-arginine translocase
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
6 September 2017
The crystal structure of the rhomboid peptidase from Haemophilus influenzae provides insight into intramembrane proteolysis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
6 September 2017
Structural basis for intramembrane proteolysis by rhomboid serine proteases
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
6 September 2017
Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
6 September 2017
A century of Alzheimer's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
6 September 2017
Two Plasmodium rhomboid proteases preferentially cleave different adhesins implicated in all invasive stages of malaria
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
6 September 2017
Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
6 September 2017
OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
6 September 2017
The gamma-secretase complex: membrane-embedded proteolytic ensemble
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
6 September 2017
Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
6 September 2017
A spatially localized rhomboid protease cleaves cell surface adhesins essential for invasion by Toxoplasma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
6 September 2017
The initial substrate-binding site of gamma-secretase is located on presenilin near the active site
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
6 September 2017
Mechanism of intramembrane proteolysis investigated with purified rhomboid proteases.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
6 September 2017
RseP (YaeL), an Escherichia coli RIP protease, cleaves transmembrane sequences
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
6 September 2017
Purification and characterization of the human gamma-secretase complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
6 September 2017
A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
6 September 2017
The SREBP pathway--insights from Insigs and insects
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
6 September 2017
Substrate specificity of rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
6 September 2017
Mitochondrial membrane remodelling regulated by a conserved rhomboid protease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
6 September 2017
Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
6 September 2017
Processing of Mgm1 by the Rhomboid-type Protease Pcp1 Is Required for Maintenance of Mitochondrial Morphology and of Mitochondrial DNA
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
6 September 2017
A novel two-step mechanism for removal of a mitochondrial signal sequence involves the mAAA complex and the putative rhomboid protease Pcp1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
6 September 2017
Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
6 September 2017
Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
6 September 2017
A family of membrane-embedded metalloproteases involved in regulated proteolysis of membrane-associated transcription factors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
6 September 2017
Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
6 September 2017
Regulated intracellular ligand transport and proteolysis control EGF signal activation in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
14 September 2017
The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the gamma-secretase.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
14 September 2017
Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
14 September 2017
Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
14 September 2017
DegS and YaeL participate sequentially in the cleavage of RseA to activate the sigma(E)-dependent extracytoplasmic stress response
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
14 September 2017
Direct and potent regulation of gamma-secretase by its lipid microenvironment
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
26 June 2018
Site-2 protease regulated intramembrane proteolysis: sequence homologs suggest an ancient signaling cascade
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
26 June 2018
Transmembrane domain 9 of presenilin determines the dynamic conformation of the catalytic site of gamma-secretase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
2 September 2018
Crystal structure of a rhomboid family intramembrane protease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
2 September 2018
Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the gamma-secretase complex.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
2 September 2018
A branched pathway governing the activation of a developmental transcription factor by regulated intramembrane proteolysis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
2 September 2018
Serine proteases from two cell types target different components of a complex that governs regulated intramembrane proteolysis of pro-sigmaK during Bacillus subtilis development
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
2 September 2018
Nicastrin functions as a gamma-secretase-substrate receptor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
2 September 2018
Characterization of the yaeL gene product and its S2P-protease motifs in Escherichia coli
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682844
retrieved
2 September 2018
Identifiers
DOI
10.1074/JBC.R800039200
1 reference
stated in
Europe PubMed Central
PMCID
2682844
retrieved
20 August 2017
PMCID
2682844
1 reference
stated in
Europe PubMed Central
PMCID
2682844
retrieved
20 August 2017
PubMed ID
19189971
1 reference
stated in
Europe PubMed Central
PMCID
2682844
retrieved
20 August 2017
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