(Q37392233)

20 August 2017

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title

Control of type 1 diabetes by CD4+Foxp3+ regulatory T cells: lessons from mouse models and implications for human disease (English)

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20 August 2017

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Evridiki Sgouroudis

1

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PubMed ID

19214972

20 August 2017

Ciriaco A Piccirillo

series ordinal

2

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20 August 2017

1 March 2009

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Diabetes - Metabolism: Research and Reviews

20 August 2017

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20 August 2017

25

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20 August 2017

3

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20 August 2017

208-218

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Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific

20 August 2017

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IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells

21 January 2018

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Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells

21 January 2018

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Multiple immuno-regulatory defects in type-1 diabetes

21 January 2018

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Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells

21 January 2018

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Costimulation controls diabetes by altering the balance of pathogenic and regulatory T cells.

21 January 2018

1 reference

Distinct effects of STAT5 activation on CD4+ and CD8+ T cell homeostasis: development of CD4+CD25+ regulatory T cells versus CD8+ memory T cells.

21 January 2018

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Uncoupling of IL-2 signaling from cell cycle progression in naive CD4+ T cells by regulatory CD4+CD25+ T lymphocytes.

21 January 2018

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Genetic control of autoimmunity in type 1 diabetes

21 January 2018

1 reference

7 January 2021

Is it dietary insulin?

1 reference

7 January 2021

Increased levels of cow's milk and beta-lactoglobulin antibodies in young children with newly diagnosed IDDM. The Childhood Diabetes in Finland Study Group

1 reference

7 January 2021

HLA-D region β-chain DNA endonuclease fragments differ between HLA-DR identical healthy and insulin-dependent diabetic individuals

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7 January 2021

Genetic polymorphisms in susceptibility to Type 1 Diabetes

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7 January 2021

The NOD mouse: a model of immune dysregulation

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7 January 2021

The non-obese diabetic (NOD) mouse: an animal model for autoimmune thyroiditis

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7 January 2021

Development of spontaneous autoimmune peripheral polyneuropathy in B7-2-deficient NOD mice.

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7 January 2021

Do the peptide-binding properties of diabetogenic class II molecules explain autoreactivity?

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7 January 2021

Nonobese diabetic mice express aspects of both type 1 and type 2 diabetes

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7 January 2021

Is pancreas development abnormal in the non-obese diabetic mouse, a spontaneous model of type I diabetes?

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7 January 2021

Resistance of the target islet tissue to autoimmune destruction contributes to genetic susceptibility in Type 1 diabetes

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7 January 2021

Congenic mapping of the diabetogenic locus Idd4 to a 5.2-cM region of chromosome 11 in NOD mice: identification of two potential candidate subloci

1 reference

7 January 2021

Immunotherapy of the nonobese diabetic mouse: treatment with an antibody to T-helper lymphocytes

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7 January 2021

Understanding autoimmune diabetes: insights from mouse models.

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7 January 2021

Transfer of autoimmune diabetes mellitus with splenocytes from nonobese diabetic (NOD) mice

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7 January 2021

The role of CD4 and CD8 T cells in the development of autoimmune diabetes

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7 January 2021

CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.

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7 January 2021

The role of CD8+ T cells in the initiation of insulin-dependent diabetes mellitus

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7 January 2021

A comprehensive guide to antibody and T-cell responses in type 1 diabetes.

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7 January 2021

Interleukin-4 deficiency does not exacerbate disease in NOD mice

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7 January 2021

Hematopoietic stem-cell defects underlying abnormal macrophage development and maturation in NOD/Lt mice: defective regulation of cytokine receptors and protein kinase C.

1 reference

7 January 2021

Impairment of NK cell function by NKG2D modulation in NOD mice

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7 January 2021

Activation of natural killer T cells by alpha-galactosylceramide treatment prevents the onset and recurrence of autoimmune Type 1 diabetes

1 reference

7 January 2021

Regulatory T-cell, endogenous antigen and neonatal environment in the prevention and induction of autoimmune disease

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7 January 2021

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

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7 January 2021

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

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7 January 2021

A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3.

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7 January 2021

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

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7 January 2021

Control of regulatory T cell development by the transcription factor Foxp3

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7 January 2021

Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3.

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7 January 2021

Foxp3-dependent programme of regulatory T-cell differentiation

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7 January 2021

Foxp3 occupancy and regulation of key target genes during T-cell stimulation

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7 January 2021

Antigen-specific FoxP3-transduced T-cells can control established type 1 diabetes

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7 January 2021

Mechanisms of suppression by suppressor T cells

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7 January 2021

CD4+Foxp3+ regulatory T cells in the control of autoimmunity: in vivo veritas

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7 January 2021

An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires

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7 January 2021

CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production

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7 January 2021

Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces

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7 January 2021

Interleukin-10-deficient mice develop chronic enterocolitis

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7 January 2021

TGFbeta signalling in control of T-cell-mediated self-reactivity

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7 January 2021

Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo

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7 January 2021

Mechanisms of regulatory T-cell suppression - a diverse arsenal for a moving target

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7 January 2021

Adaptive TGF-beta-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment

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7 January 2021

Dendritic cells with TGF-beta1 differentiate naive CD4+CD25- T cells into islet-protective Foxp3+ regulatory T cells

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7 January 2021

Acceleration of the onset of diabetes in NOD mice by thymectomy at weaning

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7 January 2021

Enhanced thymic selection of FoxP3+ regulatory T cells in the NOD mouse model of autoimmune diabetes

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7 January 2021

Functional waning of naturally occurring CD4+ regulatory T-cells contributes to the onset of autoimmune diabetes.

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7 January 2021

B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

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7 January 2021

Where CD4+CD25+ T reg cells impinge on autoimmune diabetes

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7 January 2021

Damage control, rather than unresponsiveness, effected by protective DX5+ T cells in autoimmune diabetes

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7 January 2021

Unique role of CD4+CD62L+ regulatory T cells in the control of autoimmune diabetes in T cell receptor transgenic mice

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7 January 2021

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7 January 2021

Autoimmune diabetes onset results from qualitative rather than quantitative age-dependent changes in pathogenic T-cells.

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7 January 2021

Diabetes in non-obese diabetic mice is not associated with quantitative changes in CD4+ CD25+ Foxp3+ regulatory T cells.

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7 January 2021

No alterations in the frequency of FOXP3+ regulatory T-cells in type 1 diabetes

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7 January 2021

Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes

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7 January 2021

Dynamics of pathogenic and suppressor T cells in autoimmune diabetes development

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7 January 2021

Regulatory T-cell physiology and application to treat autoimmunity

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7 January 2021

Tumor necrosis factor-alpha regulation of CD4+CD25+ T cell levels in NOD mice

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7 January 2021

Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes.

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7 January 2021

CD4+CD25high regulatory T cells in human autoimmune diabetes

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7 January 2021

Impact of protective IL-2 allelic variants on CD4+ Foxp3+ regulatory T cell function in situ and resistance to autoimmune diabetes in NOD mice

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7 January 2021

Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice

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7 January 2021

Regulatory T-cell therapy: is it ready for the clinic?

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7 January 2021

The inhibitory function of B7 costimulators in T cell responses to foreign and self-antigens

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7 January 2021

CD4 + CD25 + Cells Controlling a Pathogenic CD4 Response Inhibit Cytokine Differentiation, CXCR-3 Expression, and Tissue Invasion

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7 January 2021

In situ characterization of dendritic cells occurring in the islets of nonobese diabetic mice during the development of insulitis

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7 January 2021

Dendritic cells and macrophages are essential for the retention of lymphocytes in (peri)-insulitis of the nonobese diabetic mouse: a phagocyte depletion study

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7 January 2021

Decreased blood dendritic cell counts in type 1 diabetic children

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7 January 2021

Cell-intrinsic effects of non-MHC NOD genes on dendritic cell generation in vivo.

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7 January 2021

Defective maturation and function of antigen-presenting cells in type 1 diabetes

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7 January 2021

Cutting edge: control of CD8+ T cell activation by CD4+CD25+ immunoregulatory cells

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7 January 2021

CD4+CD25+ regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells

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7 January 2021

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

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7 January 2021

Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus

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7 January 2021

Thymic stromal lymphopoietin and thymic stromal lymphopoietin-conditioned dendritic cells induce regulatory T-cell differentiation and protection of NOD mice against diabetes

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7 January 2021

Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells

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7 January 2021

Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo

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7 January 2021

B7-1 mediated costimulation regulates pancreatic autoimmunity

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7 January 2021

B7-2 (CD86) controls the priming of autoreactive CD4 T cell response against pancreatic islets

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7 January 2021

Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse

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7 January 2021

CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion

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7 January 2021

CD154 is a negative regulator of autoaggressive CD8+ T cells in type 1 diabetes

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7 January 2021

CD40 ligation releases immature dendritic cells from the control of regulatory CD4+CD25+ T cells.

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7 January 2021

Increased T cell autoreactivity in the absence of CD40-CD40 ligand interactions: a role of CD40 in regulatory T cell development

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7 January 2021

CD40/CD40L interaction regulates CD4+CD25+ T reg homeostasis through dendritic cell-produced IL-2.

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7 January 2021

Nonredundant roles for Stat5a/b in directly regulating Foxp3

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7 January 2021

Function of the IL-2R for thymic and peripheral CD4+CD25+ Foxp3+ T regulatory cells

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7 January 2021

Essential Role for STAT5 Signaling in CD25+CD4+ Regulatory T Cell Homeostasis and the Maintenance of Self-Tolerance

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7 January 2021

Control of T cell hyperactivation in IL-2-deficient mice by CD4(+)CD25(-) and CD4(+)CD25(+) T cells: evidence for two distinct regulatory mechanisms

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7 January 2021

A function for interleukin 2 in Foxp3-expressing regulatory T cells

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7 January 2021

The main function of IL-2 is to promote the development of T regulatory cells

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7 January 2021

Tolerance, not immunity, crucially depends on IL-2.

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7 January 2021

Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling

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7 January 2021

Murine CD4+CD25+ regulatory T cells fail to undergo chromatin remodeling across the proximal promoter region of the IL-2 gene

1 reference

7 January 2021

Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity

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7 January 2021

Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

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7 January 2021

Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction

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7 January 2021

Toward further mapping of the association between the IL2RA locus and type 1 diabetes

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7 January 2021

Toward cell-based therapy of type I diabetes

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7 January 2021

Tolerogenic dendritic cells and the quest for transplant tolerance

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7 January 2021

Dendritic cell-expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice

1 reference

7 January 2021

CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes.

1 reference

7 January 2021

Identifiers

DOI

10.1002/DMRR.945

1 reference

20 August 2017

1 reference

PubMed ID

19214972