(Q37395174)

English

DNA Prime-Boost Vaccine Regimen To Increase Breadth, Magnitude, and Cytotoxicity of the Cellular Immune Responses to Subdominant Gag Epitopes of Simian Immunodeficiency Virus and HIV.

scientific article published on 12 October 2016

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25 March 2020

DNA Prime-Boost Vaccine Regimen To Increase Breadth, Magnitude, and Cytotoxicity of the Cellular Immune Responses to Subdominant Gag Epitopes of Simian Immunodeficiency Virus and HIV (English)

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Niranjan Y Sardesai

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James I Mullins

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Antonio Valentin

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Frances Dayton

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Candido Alicea

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Margherita Rosati

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Bhabadeb Chowdhury

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Rajeev Gautam

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Malcolm A Martin

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George N Pavlakis

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Barbara K Felber

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Kate E Broderick

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Journal of Immunology

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3999-4013

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25 March 2020

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1 reference

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Broadly targeted CD8⁺ T cell responses restricted by major histocompatibility complex E.

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Antigenic requirement for Gag in a vaccine that protects against high-dose mucosal challenge with simian immunodeficiency virus.

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Coordinate linkage of HIV evolution reveals regions of immunological vulnerability

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Significant protection against high-dose simian immunodeficiency virus challenge conferred by a new prime-boost vaccine regimen

1 reference

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Long peptides induce polyfunctional T cells against conserved regions of HIV-1 with superior breadth to single-gene vaccines in macaques.

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Long-lasting humoral and cellular immune responses and mucosal dissemination after intramuscular DNA immunization

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Repeated DNA therapeutic vaccination of chronically SIV-infected macaques provides additional virological benefit

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T-cell correlates of vaccine efficacy after a heterologous simian immunodeficiency virus challenge

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HIV-1 group M conserved elements vaccine

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Identifiers

10.4049/JIMMUNOL.1600697

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25 March 2020

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25 March 2020

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