(Q37395399)

20 August 2017

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title

SHH pathway and cerebellar development (English)

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20 August 2017

Catherine Vaillant

1

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PubMed ID

19224309

20 August 2017

Denis Monard

series ordinal

2

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20 August 2017

18 February 2009

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20 August 2017

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20 August 2017

8

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20 August 2017

291-301

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20 August 2017

3

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https://scigraph.springernature.com/pub.10.1007/s12311-009-0094-8

20 August 2017

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c-Myc enhances sonic hedgehog-induced medulloblastoma formation from nestin-expressing neural progenitors in mice

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Gli1 is important for medulloblastoma formation in Ptc1+/- mice

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Sonic hedgehog in normal and neoplastic proliferation: insight gained from human tumors and animal models

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12 December 2020

Altered neural cell fates and medulloblastoma in mouse patched mutants

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Development of mice expressing a single D-type cyclin.

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Kinematic and electromyographic characteristics of single-joint movements of individuals with Down syndrome

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12 December 2020

Genes involved in cerebellar cell specification and differentiation

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12 December 2020

Loss of cyclin D1 impairs cerebellar development and suppresses medulloblastoma formation

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12 December 2020

Cerebellar development and disease

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12 December 2020

Isolation of neural stem cells from the postnatal cerebellum

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12 December 2020

Cilia Proteins Control Cerebellar Morphogenesis by Promoting Expansion of the Granule Progenitor Pool

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12 December 2020

Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development

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12 December 2020

Morphogen to mitogen: the multiple roles of hedgehog signalling in vertebrate neural development

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12 December 2020

REN: a novel, developmentally regulated gene that promotes neural cell differentiation

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12 December 2020

Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas

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12 December 2020

Effects of basic fibroblastic growth factor on the growth of human medulloblastoma xenografts

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12 December 2020

Sonic hedgehog signaling is required for expansion of granule neuron precursors and patterning of the mouse cerebellum

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12 December 2020

Patched target Igf2 is indispensable for the formation of medulloblastoma and rhabdomyosarcoma.

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12 December 2020

The role of Zic genes in neural development.

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12 December 2020

Antitumor activity of fibroblast growth factors (FGFs) for medulloblastoma may correlate with FGF receptor expression and tumor variant

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12 December 2020

Beta1-integrins are critical for cerebellar granule cell precursor proliferation

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12 December 2020

Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates

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12 December 2020

Sonic hedgehog regulates the growth and patterning of the cerebellum

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12 December 2020

Cerebellar proteoglycans regulate sonic hedgehog responses during development.

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12 December 2020

Discrete localizations of hedgehog signalling components in the developing and adult rat nervous system.

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12 December 2020

Hedgehog checkpoints in medulloblastoma: the chromosome 17p deletion paradigm.

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12 December 2020

A novel role of the Mad family member Mad3 in cerebellar granule neuron precursor proliferation

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12 December 2020

Bmp2 antagonizes sonic hedgehog-mediated proliferation of cerebellar granule neurones through Smad5 signalling.

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12 December 2020

Limb, genital, CNS, and facial malformations result from gene/environment-induced cholesterol deficiency: further evidence for a link to sonic hedgehog.

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12 December 2020

Cancerous stem cells can arise from pediatric brain tumors

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12 December 2020

Morphology, molecular codes, and circuitry produce the three-dimensional complexity of the cerebellum

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12 December 2020

Morphing into cancer: the role of developmental signaling pathways in brain tumor formation

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12 December 2020

Bone morphogenetic protein 2 opposes Shh-mediated proliferation in cerebellar granule cells through a TIEG-1-based regulation of Nmyc.

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12 December 2020

Patched1 regulates hedgehog signaling at the primary cilium

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12 December 2020

Forkhead transcription factor FoxM1 regulates mitotic entry and prevents spindle defects in cerebellar granule neuron precursors.

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12 December 2020

Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma

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12 December 2020

Down syndrome gene dosage imbalance on cerebellum development

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12 December 2020

BMPs oppose Math1 in cerebellar development and in medulloblastoma.

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12 December 2020

N-myc can substitute for insulin-like growth factor signaling in a mouse model of sonic hedgehog-induced medulloblastoma.

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12 December 2020

Hedgehog and PI-3 kinase signaling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursors.

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12 December 2020

Sonic hedgehog and insulin-like growth factor signaling synergize to induce medulloblastoma formation from nestin-expressing neural progenitors in mice

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12 December 2020

REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma

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12 December 2020

Medulloblastoma growth inhibition by hedgehog pathway blockade

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12 December 2020

The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors.

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12 December 2020

Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells

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12 December 2020

Developmental roles and clinical significance of hedgehog signaling

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12 December 2020

A molecular fingerprint for medulloblastoma.

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12 December 2020

Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.

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12 December 2020

Activation of ERK signaling upon alternative protease nexin-1 internalization mediated by syndecan-1

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12 December 2020

Defective forebrain development in mice lacking gp330/megalin

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12 December 2020

Control of glial precursor cell development in the mouse optic nerve by sonic hedgehog from retinal ganglion cells

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12 December 2020

A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors.

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12 December 2020

Hedgehog antagonist REN(KCTD11) regulates proliferation and apoptosis of developing granule cell progenitors

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12 December 2020

Smoothened activates Galphai-mediated signaling in frog melanophores

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12 December 2020

Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors

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12 December 2020

Turnover of the active fraction of IRS1 involves raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosis

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12 December 2020

Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination.

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12 December 2020

Genetic basis of Joubert syndrome and related disorders of cerebellar development

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12 December 2020

Megalin and the neurodevelopmental biology of sonic hedgehog and retinol

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12 December 2020

Insulin receptor substrate 1 is an effector of sonic hedgehog mitogenic signaling in cerebellar neural precursors

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12 December 2020

Fibroblast growth factor blocks Sonic hedgehog signaling in neuronal precursors and tumor cells.

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12 December 2020

Pathogenesis of malformations in a rodent model for Smith-Lemli-Opitz syndrome

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12 December 2020

MMP-9 deficiency affects axonal outgrowth, migration, and apoptosis in the developing cerebellum.

1 reference

12 December 2020

Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum

1 reference

12 December 2020

Spatiotemporal expression patterns of metalloproteinases and their inhibitors in the postnatal developing rat cerebellum.

1 reference

12 December 2020

Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system

1 reference

12 December 2020

Human malformation syndromes due to inborn errors of cholesterol synthesis

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12 December 2020

Molecular genetic studies in medulloblastomas: evidence for tumor suppressor genes at the chromosomal regions 1q31-32 and 17p13.

1 reference

12 December 2020

A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway

1 reference

12 December 2020

Defective cerebellar response to mitogenic Hedgehog signaling in Down [corrected] syndrome mice

1 reference

12 December 2020

Identification of genes expressed with temporal-spatial restriction to developing cerebellar neuron precursors by a functional genomic approach

1 reference

12 December 2020

Molecular analysis of gene expression in the developing pontocerebellar projection system

1 reference

12 December 2020

Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog

1 reference

12 December 2020

Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells

1 reference

12 December 2020

Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors

1 reference

12 December 2020

Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastoma

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12 December 2020

Prediction of central nervous system embryonal tumour outcome based on gene expression

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12 December 2020

Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched.

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12 December 2020

Teratogenic effect of the cholesterol synthesis inhibitor AY 9944 on rat embryos in vitro

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12 December 2020

Protease nexin 1 and its receptor LRP modulate SHH signalling during cerebellar development

1 reference

12 December 2020

Insulin-like growth factor 2 is required for progression to advanced medulloblastoma in patched1 heterozygous mice

1 reference

12 December 2020

Vitronectin regulates Sonic hedgehog activity during cerebellum development through CREB phosphorylation.

1 reference

12 December 2020

Sonic hedgehog promotes G(1) cyclin expression and sustained cell cycle progression in mammalian neuronal precursors

1 reference

12 December 2020

Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells

1 reference

12 December 2020

Primary cilia are required for cerebellar development and Shh-dependent expansion of progenitor pool

1 reference

12 December 2020

Murine numb regulates granule cell maturation in the cerebellum

1 reference

12 December 2020

Recent insights into the Smith-Lemli-Opitz syndrome

1 reference

12 December 2020

Loss of suppressor-of-fused function promotes tumorigenesis.

1 reference

12 December 2020

SDF-1 alpha induces chemotaxis and enhances Sonic hedgehog-induced proliferation of cerebellar granule cells.

1 reference

12 December 2020

The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation

1 reference

12 December 2020

Hedgehog: functions and mechanisms

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12 December 2020

The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance

1 reference

12 December 2020

Induction of medulloblastomas in mice by sonic hedgehog, independent of Gli1.

1 reference

12 December 2020

N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation

1 reference

12 December 2020

Interactions between retinoic acid, nerve growth factor and sonic hedgehog signalling pathways in neurite outgrowth.

1 reference

12 December 2020

Regional distribution of Sonic Hedgehog, patched, and smoothened mRNA in the adult rat brain

1 reference

12 December 2020

Pituitary adenylate cyclase-activating polypeptide and sonic hedgehog interact to control cerebellar granule precursor cell proliferation

1 reference

12 December 2020

Nevoid basal cell carcinoma syndrome

1 reference

12 December 2020

Cerebellar histogenesis is disturbed in mice lacking cyclin D2.

1 reference

12 December 2020

Mutations in SUFU predispose to medulloblastoma

1 reference

12 December 2020

Critical role of integrin-linked kinase in granule cell precursor proliferation and cerebellar development

1 reference

12 December 2020

In search of the medulloblast: neural stem cells and embryonal brain tumors

1 reference

12 December 2020

The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas

1 reference

12 December 2020

10.1007/S12311-009-0094-8

Identifiers

DOI

1 reference

20 August 2017

1 reference

PubMed ID

19224309