(Q37406947)

English

AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis

scientific article published on 23 October 2009

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scholarly article

1 reference

Europe PubMed Central

20 August 2017

AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis (English)

1 reference

Europe PubMed Central

20 August 2017

apoptotic process

0 references

Rianne Siebelink-Stoter

2

object named as

Rianne Stoter

1 reference

Europe PubMed Central

20 August 2017

5

object named as

Marc E Lippman

1 reference

Europe PubMed Central

20 August 2017

author name string

Shuraila F Zerp

1

1 reference

Europe PubMed Central

20 August 2017

Gitta Kuipers

3

1 reference

Europe PubMed Central

20 August 2017

Dajun Yang

4

1 reference

Europe PubMed Central

20 August 2017

Wim J van Blitterswijk

6

1 reference

Europe PubMed Central

20 August 2017

Harry Bartelink

7

1 reference

Europe PubMed Central

20 August 2017

Rogier Rooswinkel

8

1 reference

Europe PubMed Central

20 August 2017

Vincent Lafleur

9

1 reference

Europe PubMed Central

20 August 2017

Marcel Verheij

10

1 reference

Europe PubMed Central

20 August 2017

publication date

23 October 2009

1 reference

Europe PubMed Central

20 August 2017

Radiation Oncology

1 reference

Europe PubMed Central

20 August 2017

4

1 reference

Europe PubMed Central

20 August 2017

47

1 reference

Europe PubMed Central

20 August 2017

https://scigraph.springernature.com/pub.10.1186/1748-717x-4-47

0 references

Bcl-2 antagonists interact synergistically with bortezomib in DLBCL cells in association with JNK activation and induction of ER stress

1 reference

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Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy

1 reference

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R-(-)-gossypol (AT-101) activates programmed cell death in multiple myeloma cells.

1 reference

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6 September 2017

Combined targeting of epidermal growth factor receptor, signal transducer and activator of transcription-3, and Bcl-X(L) enhances antitumor effects in squamous cell carcinoma of the head and neck.

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Controlling the cell death mediators Bax and Bak: puzzles and conundrums

1 reference

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In vivo evaluation of AT-101 (R-(-)-gossypol acetic acid) in androgen-independent growth of VCaP prostate cancer cells in combination with surgical castration

1 reference

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(-)-gossypol inhibits growth and promotes apoptosis of human head and neck squamous cell carcinoma in vivo

1 reference

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Apoptosis-modulating agents in combination with radiotherapy-current status and outlook

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Alkyl-lysophospholipids as anticancer agents and enhancers of radiation-induced apoptosis

1 reference

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6 September 2017

BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.

1 reference

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Gossypol treatment of recurrent adult malignant gliomas

1 reference

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6 September 2017

The role of the stress-activated protein kinase (SAPK/JNK) signaling pathway in radiation-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771029

6 September 2017

Immunohistochemical analysis of Bcl-2, Bcl-X, Mcl-1, and Bax in tumors of central and peripheral nervous system origin

1 reference

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Bcl-2 expression and response to chemotherapy in colorectal adenocarcinomas.

1 reference

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6 September 2017

Oral gossypol in the treatment of metastatic adrenal cancer

1 reference

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6 September 2017

Prognostic value of bcl-2 expression in invasive breast cancer

1 reference

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Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

1 reference

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6 September 2017

Synergistic cytotoxicity of Bcl-xL inhibitor, gossypol and chemotherapeutic agents in non-Hodgkin's lymphoma cells

1 reference

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Radiosensitization of tumour cell lines by the polyphenol Gossypol results from depressed double-strand break repair and not from enhanced apoptosis

1 reference

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Gossypol induces apoptosis in human PC-3 prostate cancer cells by modulating caspase-dependent and caspase-independent cell death pathways

1 reference

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In vitro effects of the BH3 mimetic, (-)-gossypol, on head and neck squamous cell carcinoma cells.

1 reference

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Phosphorylation and inactivation of myeloid cell leukemia 1 by JNK in response to oxidative stress

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Structure-activity studies on gossypol in tumor cell lines

1 reference

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Alkyl-lysophospholipids activate the SAPK/JNK pathway and enhance radiation-induced apoptosis

1 reference

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Bcl-xL blocks activation of related adhesion focal tyrosine kinase/proline-rich tyrosine kinase 2 and stress-activated protein kinase/c-Jun N-terminal protein kinase in the cellular response to methylmethane sulfonate

1 reference

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BCL-2 family proteins: regulators of cell death involved in the pathogenesis of cancer and resistance to therapy

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The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat

1 reference

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Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.

1 reference

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Expression of Bcl-2 family proteins in advanced laryngeal squamous cell carcinoma: correlation with response to chemotherapy and organ preservation

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(-)Gossypol and its combination with imatinib induce apoptosis in human chronic myeloid leukemic cells

1 reference

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Reversal of cisplatin resistance with a BH3 mimetic, (-)-gossypol, in head and neck cancer cells: role of wild-type p53 and Bcl-xL.

1 reference

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(-)-Gossypol acts directly on the mitochondria to overcome Bcl-2- and Bcl-X(L)-mediated apoptosis resistance

1 reference

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The (-)-enantiomer of gossypol possesses higher anticancer potency than racemic gossypol in human breast cancer.

1 reference

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Oral gossypol in the treatment of patients with refractory metastatic breast cancer: a phase I/II clinical trial.

1 reference

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Cumulative prognostic value of p53 mutations and bcl-2 protein expression in head-and-neck cancer treated by radiotherapy.

1 reference

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Bcl-xL and Bcl-2 expression in squamous cell carcinoma of the head and neck.

1 reference

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Suppression of oncogene-induced transformation by a deletion mutant of c-jun.

1 reference

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2 September 2018

Expression of bcl-xL can confer a multidrug resistance phenotype.

1 reference

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2 September 2018

Translocation of SAPK/JNK to mitochondria and interaction with Bcl-x(L) in response to DNA damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/19852810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic factors in transitional cell cancer of the bladder: an emerging role for Bcl-2 and p53

1 reference

https://pubmed.ncbi.nlm.nih.gov/19852810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19852810

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based on heuristic

inferred from PubMed ID database lookup

Bcl-2 and Bcl-XL can differentially block chemotherapy-induced cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/19852810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of BCL-x protein in primary breast cancer is associated with high tumor grade and nodal metastases

1 reference

https://pubmed.ncbi.nlm.nih.gov/19852810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stereo-specific cytotoxic effects of gossypol enantiomers and gossypolone in tumour cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/19852810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preclinical studies of a nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-X(L) [(-)-gossypol] against diffuse large cell lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/19852810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

(-)-Gossypol enhances response to radiation therapy and results in tumor regression of human prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19852810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/19852810

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1748-717X-4-47

1 reference

Europe PubMed Central

20 August 2017

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0 references

1 reference

Europe PubMed Central

20 August 2017

1 reference

Europe PubMed Central

20 August 2017

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