(Q37414369)

20 August 2017

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title

Tumor suppressor genes in myeloid differentiation and leukemogenesis (English)

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20 August 2017

Christian Britschgi

1

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20 August 2017

Martin F Fey

series ordinal

2

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20 August 2017

language of work or name

English

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publication date

1 March 2009

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20 August 2017

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20 August 2017

volume

5

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20 August 2017

issue

2

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20 August 2017

page(s)

245-257

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Two genetic hits (more or less) to cancer

20 August 2017

cites work

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

Dmp1 and tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

Worms gang up on bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

Determinants of lymphoid-myeloid lineage diversification

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

Disruption of differentiation in human cancer: AML shows the way.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

Transcription factors in myeloid development: balancing differentiation with transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

21 January 2018

Acute myeloid leukaemia

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

The molecular pathogenesis of acute promyelocytic leukaemia: implications for the clinical management of the disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

Genetics of myeloid malignancies: pathogenetic and clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

Methylation profiling in acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

Histone Deacetylase Inhibitor Romidepsin Has Differential Activity in Core Binding Factor Acute Myeloid Leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

p53 is a regulator of macrophage differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

Staf50 is a novel p53 target gene conferring reduced clonogenic growth of leukemic U-937 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

21 January 2018

Surfing the p53 network

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

Live or let die: the cell's response to p53

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

p53, the cellular gatekeeper for growth and division

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

PUMA, a novel proapoptotic gene, is induced by p53

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

HIC1 tumour suppressor gene is suppressed in acute myeloid leukaemia and induced during granulocytic differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

Identification of the p53 family-responsive element in the promoter region of the tumor suppressor gene hypermethylated in cancer 1

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

PML is a direct p53 target that modulates p53 effector functions

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

Impairment of p53 acetylation, stability and function by an oncogenic transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

Tailoring to RB: tumour suppressor status and therapeutic response

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

C/EBPepsilon interacts with retinoblastoma and E2F1 during granulopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

Tumor suppressor genes in normal and malignant hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

Expression and regulation of G1 cell-cycle inhibitors (p16INK4A, p15INK4B, p18INK4C, p19INK4D) in human acute myeloid leukemia and normal myeloid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

Divorcing ARF and p53: an unsettled case

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

The prognostic significance of p16(INK4a)/p14(ARF) locus deletion and MDM-2 protein expression in adult acute myelogenous leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

21 January 2018

Nucleophosmin and cancer

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

Delocalization and destabilization of the Arf tumor suppressor by the leukemia-associated NPM mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

The t(8;21) fusion protein, AML1 ETO, specifically represses the transcription of the p14(ARF) tumor suppressor in acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

The inv(16) cooperates with ARF haploinsufficiency to induce acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

Regulation of p53 activity in nuclear bodies by a specific PML isoform

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

PML4 induces differentiation by Myc destabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

PML-retinoic acid receptor alpha inhibits PML IV enhancement of PU.1-induced C/EBPepsilon expression in myeloid differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

Physical and functional link of the leukemia-associated factors AML1 and PML.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

Cytoplasmic PML function in TGF-beta signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

Interferon regulatory factor-8 is indispensable for the expression of promyelocytic leukemia and the formation of nuclear bodies in myeloid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

PML regulates p53 stability by sequestering Mdm2 to the nucleolus

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

PML targeting eradicates quiescent leukaemia-initiating cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

The biology of chronic myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

Chronic myeloid leukaemia as a model of disease evolution in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

BCR/ABL translocates to the nucleus and disrupts an ATR-dependent intra-S phase checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

BCR-ABL down-regulates the DNA repair protein DNA-PKcs

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

BCR-ABL suppresses C/EBPalpha expression through inhibitory action of hnRNP E2.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

p53 in chronic myelogenous leukemia in acute phase

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

BCR/ABL activates mdm2 mRNA translation via the La antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

Modeling the therapeutic efficacy of p53 restoration in tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

Mutated and non-mutated TP53 as targets in the treatment of leukaemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

PRIMA-1 induces apoptosis in acute myeloid leukaemia cells with p53 gene deletion

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

Sunitinib versus interferon alfa in metastatic renal-cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

Genomic p16 abnormalities in the progression of chronic myeloid leukemia into blast crisis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.5.2.245

21 January 2018

Identifiers

DOI

10.2217/14796694.5.2.245

1 reference

20 August 2017

1 reference