(Q37427453)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27917297%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

title

An intrinsic agonist mechanism for activation of glucagon-like peptide-1 receptor by its extracellular domain (English)

1 reference

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28 March 2020

8

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28 March 2020

author name string

Yanting Yin

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27917297%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

X Edward Zhou

2

1 reference

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28 March 2020

Li Hou

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27917297%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

Li-Hua Zhao

4

1 reference

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28 March 2020

Bo Liu

5

1 reference

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28 March 2020

Gaihong Wang

6

1 reference

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28 March 2020

Yi Jiang

7

1 reference

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28 March 2020

H Eric Xu

9

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28 March 2020

publication date

22 November 2016

1 reference

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28 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27917297%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

volume

2

1 reference

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28 March 2020

page(s)

16042

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Creative Commons Attribution 4.0 International

28 March 2020

copyright license

start time

22 November 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5118412/fullTextXML

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/celldisc.2016.42

0 references

cites work

Structural basis of Smoothened regulation by its extracellular domains

1 reference

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The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism

23 August 2017

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Differential Requirement of the Extracellular Domain in Activation of Class B G Protein-coupled Receptors

23 August 2017

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Extra-helical binding site of a glucagon receptor antagonist

23 August 2017

1 reference

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Conformational states of the full-length glucagon receptor

23 August 2017

1 reference

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Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

23 August 2017

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Ligand binding pocket formed by evolutionarily conserved residues in the glucagon-like peptide-1 (GLP-1) receptor core domain

23 August 2017

1 reference

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Inhibitory Mechanism of an Allosteric Antibody Targeting the Glucagon Receptor

23 August 2017

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Structure of class B GPCR corticotropin-releasing factor receptor 1

23 August 2017

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Structure of the human glucagon class B G-protein-coupled receptor

23 August 2017

1 reference

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NIH Image to ImageJ: 25 years of image analysis

23 August 2017

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Molecular basis for negative regulation of the glucagon receptor

23 August 2017

1 reference

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Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) has a critical role in GLP-1 peptide binding and receptor activation

23 August 2017

1 reference

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Site of action of a pentapeptide agonist at the glucagon-like peptide-1 receptor. Insight into a small molecule agonist-binding pocket

23 August 2017

1 reference

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Biased signalling and allosteric machines: new vistas and challenges for drug discovery

23 August 2017

1 reference

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The structure and function of the glucagon-like peptide-1 receptor and its ligands

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5118412

Crystal structure of the β2 adrenergic receptor-Gs protein complex

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5118412

Crystal Structure of the PAC1R Extracellular Domain Unifies a Consensus Fold for Hormone Recognition by Class B G-Protein Coupled Receptors

23 August 2017

1 reference

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Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism

23 August 2017

1 reference

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Novel small molecule glucagon-like peptide-1 receptor agonist stimulates insulin secretion in rodents and from human islets

23 August 2017

1 reference

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Glucagon-like peptide 1 receptor stimulation as a means of neuroprotection

23 August 2017

1 reference

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Structural basis for parathyroid hormone-related protein binding to the parathyroid hormone receptor and design of conformation-selective peptides

23 August 2017

1 reference

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The structure and function of G-protein-coupled receptors

23 August 2017

1 reference

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Passing the baton in class B GPCRs: peptide hormone activation via helix induction?

23 August 2017

1 reference

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Membrane-tethered ligands are effective probes for exploring class B1 G protein-coupled receptor function

23 August 2017

1 reference

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Molecular recognition of corticotropin-releasing factor by its G-protein-coupled receptor CRFR1

23 August 2017

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Beta-Arrestin-1 mediates glucagon-like peptide-1 signaling to insulin secretion in cultured pancreatic beta cells

23 August 2017

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Exploration of the endogenous agonist mechanism for activation of secretin and VPAC1 receptors using synthetic glycosylated peptides

23 August 2017

1 reference

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Molecular recognition of parathyroid hormone by its G protein-coupled receptor

23 August 2017

1 reference

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Insights into the structural basis of endogenous agonist activation of family B G protein-coupled receptors

23 August 2017

1 reference

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Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain

23 August 2017

1 reference

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The genetic design of signaling cascades to record receptor activation

23 August 2017

1 reference

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Biology of incretins: GLP-1 and GIP

23 August 2017

1 reference

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NMR structure and peptide hormone binding site of the first extracellular domain of a type B1 G protein-coupled receptor

23 August 2017

1 reference

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Constitutive activation of tethered-peptide/corticotropin-releasing factor receptor chimeras

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5118412

Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5118412

Extracellular loops 1 and 3 and their associated transmembrane regions of the calcitonin receptor-like receptor are needed for CGRP receptor function

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5118412

The major determinant of exendin-4/glucagon-like peptide 1 differential affinity at the rat glucagon-like peptide 1 receptor N-terminal domain is a hydrogen bond from SER-32 of exendin-4.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5118412

Possible endogenous agonist mechanism for the activation of secretin family G protein-coupled receptors

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5118412

Met-204 and Tyr-205 are together important for binding GLP-1 receptor agonists but not their N-terminally truncated analogues

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5118412

Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5118412

Dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1 which have extended metabolic stability and improved biological activity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5118412

A potentiator of orthosteric ligand activity at GLP-1R acts via covalent modification.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5118412

Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: effects of exogenous glucagon-like peptide-1 (GLP-1)-(7-36) amide in type 2 (noninsulin-dependent) diabetic patients.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5118412

Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5118412

Effect of truncated glucagon-like peptide-1 [proglucagon-(78-107) amide] on endocrine secretion from pig pancreas, antrum, and nonantral stomach.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5118412

Development of a cysteine-deprived and C-terminally truncated GLP-1 receptor.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5118412

Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5118412

Glucagon-like peptide-1 promotes satiety and reduces food intake in patients with diabetes mellitus type 2.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5118412

Truncated GLP-1 (proglucagon 78-107-amide) inhibits gastric and pancreatic functions in man.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5118412

Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV

2 September 2018

1 reference

https://api.crossref.org/works/10.1038%2FCELLDISC.2016.42

7 January 2021

Class-B GPCR activation: is ligand helix-capping the key?

1 reference

https://api.crossref.org/works/10.1038%2FCELLDISC.2016.42

7 January 2021

High potency antagonists of the pancreatic glucagon-like peptide-1 receptor

1 reference

https://api.crossref.org/works/10.1038%2FCELLDISC.2016.42

7 January 2021

Analysis of the glucagon receptor first extracellular loop by the substituted cysteine accessibility method

1 reference

https://api.crossref.org/works/10.1038%2FCELLDISC.2016.42

7 January 2021

Identifiers

DOI

10.1038/CELLDISC.2016.42

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27917297%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27917297%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

PubMed publication ID

27917297

1 reference