(Q42704926)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24997604%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

title

A potentiator of orthosteric ligand activity at GLP-1R acts via covalent modification (English)

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21 March 2020

5

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21 March 2020

author name string

Whitney M Nolte

1

1 reference

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21 March 2020

Jean-Philippe Fortin

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24997604%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

Benjamin D Stevens

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24997604%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

Gary E Aspnes

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24997604%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

Lise R Hoth

6

1 reference

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21 March 2020

Roger B Ruggeri

7

1 reference

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21 March 2020

Alan M Mathiowetz

8

1 reference

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21 March 2020

Chris Limberakis

9

1 reference

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21 March 2020

David Hepworth

10

1 reference

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21 March 2020

Philip A Carpino

11

1 reference

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21 March 2020

publication date

6 July 2014

1 reference

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21 March 2020

published in

Nature Chemical Biology

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21 March 2020

volume

10

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21 March 2020

issue

8

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21 March 2020

page(s)

629-631

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Clinical endocrinology and metabolism. Glucagon-like peptide-1 and glucagon-like peptide-2.

21 March 2020

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1581

GLP-1 mediates antiapoptotic effect by phosphorylating Bad through a beta-arrestin 1-mediated ERK1/2 activation in pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1581

Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: implications for drug screening.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1581

Beyond glucose lowering: glucagon-like peptide-1 receptor agonists, body weight and the cardiovascular system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1581

Allosteric modulation of the activity of the glucagon-like peptide-1 (GLP-1) metabolite GLP-1 9-36 amide at the GLP-1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1581

Small molecule allosteric modulation of the glucagon-like Peptide-1 receptor enhances the insulinotropic effect of oxyntomodulin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1581

Allosteric modulation of endogenous metabolites as an avenue for drug discovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1581

Novel small molecule glucagon-like peptide-1 receptor agonist stimulates insulin secretion in rodents and from human islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1581

Demonstration of the innate electrophilicity of 4-(3-(benzyloxy)phenyl)-2-(ethylsulfinyl)-6-(trifluoromethyl)pyrimidine (BETP), a small-molecule positive allosteric modulator of the glucagon-like peptide-1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1581

Chronic exposure to GLP-1R agonists promotes homologous GLP-1 receptor desensitization in vitro but does not attenuate GLP-1R-dependent glucose homeostasis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1581

The role of incretins in glucose homeostasis and diabetes treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1581

Development of a cysteine-deprived and C-terminally truncated GLP-1 receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1581

Differential activation and modulation of the glucagon-like peptide-1 receptor by small molecule ligands.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1581

Substitution of the cysteine 438 residue in the cytoplasmic tail of the glucagon-like peptide-1 receptor alters signal transduction activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1581

Dipeptidyl peptidase IV (DPIV/CD26) degradation of glucagon. Characterization of glucagon degradation products and DPIV-resistant analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1581

Structure of the human glucagon class B G-protein-coupled receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1581

Small molecule ago-allosteric modulators of the human glucagon-like peptide-1 (hGLP-1) receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1581

Scanning of the glucagon-like peptide-1 receptor localizes G protein-activating determinants primarily to the N terminus of the third intracellular loop

21 January 2018

1 reference

12 December 2020

Physiology and emerging biochemistry of the glucagon-like peptide-1 receptor

1 reference

12 December 2020

Mutation of the two carboxyl-terminal tyrosines results in an insulin receptor with normal metabolic signaling but enhanced mitogenic signaling properties

1 reference

12 December 2020

Small molecule drug discovery at the glucagon-like peptide-1 receptor

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCHEMBIO.1581

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24997604%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

1 reference