(Q37445026)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27852778%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

title

The Effects of Peripheral and Central High Insulin on Brain Insulin Signaling and Amyloid-β in Young and Old APP/PS1 Mice (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27852778%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27852778%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

Shannon L Macauley

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27852778%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

Emily E Caesar

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27852778%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

Grace O Robinson

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27852778%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

Joseph Roh

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27852778%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

10

David M Holtzman

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27852778%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

author name string

Lauren J Koscal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27852778%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

Will Moritz

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27852778%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

Jennifer Keyser

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27852778%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

Hong Jiang

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27852778%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

language of work or name

English

0 references

publication date

1 November 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27852778%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

published in

Journal of Neuroscience

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27852778%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

volume

36

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27852778%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

issue

46

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27852778%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

page(s)

11704-11715

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27852778%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

27 March 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5125227/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Brain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1α and Increases in Aβ1-40/42 and Phospho-Tau May Abet Alzheimer Development

23 August 2017

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Aerobic Glycolysis in the Frontal Cortex Correlates with Memory Performance in Wild-Type Mice But Not the APP/PS1 Mouse Model of Cerebral Amyloidosis

23 August 2017

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Three dimensions of the amyloid hypothesis: time, space and 'wingmen'

23 August 2017

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The brain response to peripheral insulin declines with age: a contribution of the blood-brain barrier?

23 August 2017

1 reference

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Plasma Lactate Levels Increase during Hyperinsulinemic Euglycemic Clamp and Oral Glucose Tolerance Test

23 August 2017

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Hyperglycemia modulates extracellular amyloid-β concentrations and neuronal activity in vivo

23 August 2017

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Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer's disease and tauopathies

23 August 2017

1 reference

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Insulin resistance predicts brain amyloid deposition in late middle-aged adults.

23 August 2017

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Sleep drives metabolite clearance from the adult brain

23 August 2017

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Hyperinsulinemia drives diet-induced obesity independently of brain insulin production

23 August 2017

1 reference

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Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

23 August 2017

1 reference

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An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers

23 August 2017

1 reference

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Insulin receptor signaling mediates APP processing and β-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer's disease

23 August 2017

1 reference

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Neuronal activity regulates the regional vulnerability to amyloid-β deposition

23 August 2017

1 reference

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Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

23 August 2017

1 reference

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Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

23 August 2017

1 reference

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Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

23 August 2017

1 reference

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Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies

23 August 2017

1 reference

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Physiological and pathological changes in glucose regulate brain Akt and glycogen synthase kinase-3.

23 August 2017

1 reference

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The role of insulin receptor signaling in the brain

23 August 2017

1 reference

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Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases

23 August 2017

1 reference

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The source of cerebral insulin

23 August 2017

1 reference

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Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

23 August 2017

1 reference

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Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling.

23 August 2017

1 reference

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Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

23 August 2017

1 reference

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Association between features of the insulin resistance syndrome and Alzheimer's disease independently of apolipoprotein E4 phenotype: cross sectional population based study

23 August 2017

1 reference

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Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain

23 August 2017

1 reference

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Functionally distinct insulin receptors generated by tissue-specific alternative splicing

23 August 2017

1 reference

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Alzheimer's disease: the challenge of the second century

23 August 2017

1 reference

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How does diabetes accelerate Alzheimer disease pathology?

23 August 2017

1 reference

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Insulin has multiple antiamyloidogenic effects on human neuronal cells

23 August 2017

1 reference

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Hippocampal memory processes are modulated by insulin and high-fat-induced insulin resistance

6 September 2017

1 reference

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Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: relationship to severity of dementia and apolipoprotein E genotype.

28 September 2017

1 reference

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Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5125227

Increased insulin levels after OGTT load in peripheral blood and cerebrospinal fluid of patients with dementia of Alzheimer type.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5125227

The signaling potential of the receptors for insulin and insulin-like growth factor I (IGF-I) in 3T3-L1 adipocytes: comparison of glucose transport activity, induction of oncogene c-fos, glucose transporter mRNA, and DNA-synthesis

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5125227

Peripheral Blood Adipokines and Insulin Levels in Patients with Alzheimer's Disease: A Replication Study and Meta-Analysis.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5125227

Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5125227

US government sets out Alzheimer's plan.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5125227

Considerations in the design of hyperinsulinemic-euglycemic clamps in the conscious mouse

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5125227

Peripheral hyperinsulinemia promotes tau phosphorylation in vivo

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5125227

Hyperinsulinemia provokes synchronous increases in central inflammation and beta-amyloid in normal adults

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5125227

Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer's disease intervention.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5125227

Brain insulin impairs amyloid-beta(1-40) clearance from the brain.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5125227

Hyperinsulinemia and risk of Alzheimer disease.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5125227

In VivoAssessment of Brain Interstitial Fluid with Microdialysis Reveals Plaque-Associated Changes in Amyloid-β Metabolism and Half-Life

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5125227

Insulin increases CSF Abeta42 levels in normal older adults

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5125227

RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5125227

Blood-brain barrier uptake of the 40 and 42 amino acid sequences of circulating Alzheimer's amyloid beta in guinea pigs

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5125227

Passage of human amyloid beta-protein 1-40 across the murine blood-brain barrier

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5125227

Amyloid beta oligomers induce impairment of neuronal insulin receptors

2 September 2018

1 reference

12 December 2020

Reduced effect of experimental peripheral hyperinsulinemia to elevate cerebrospinal fluid insulin concentrations of obese Zucker rats

1 reference

12 December 2020

Selective, physiological transport of insulin across the blood-brain barrier: novel demonstration by species-specific radioimmunoassays

1 reference

12 December 2020

Insulin signaling and insulin sensitivity after exercise in human skeletal muscle

1 reference

12 December 2020

10.1523/JNEUROSCI.2119-16.2016

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27852778%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27852778%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

PubMed publication ID

27852778

1 reference