(Q36528274)

English

Insulin receptor signaling mediates APP processing and β-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer's disease

scientific article published on 6 November 2011

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scholarly article

1 reference

Europe PubMed Central

14 August 2017

Insulin receptor signaling mediates APP processing and β-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer's disease (English)

1 reference

Europe PubMed Central

14 August 2017

Alzheimer's disease

0 references

Jens C Brüning

9

object named as

Jens C Brüning

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Europe PubMed Central

14 August 2017

author name string

Oliver Stöhr

1

1 reference

Europe PubMed Central

14 August 2017

Katharina Schilbach

2

1 reference

Europe PubMed Central

14 August 2017

Lorna Moll

3

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Europe PubMed Central

14 August 2017

Moritz M Hettich

4

1 reference

Europe PubMed Central

14 August 2017

Susanna Freude

5

1 reference

Europe PubMed Central

14 August 2017

F Thomas Wunderlich

6

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Europe PubMed Central

14 August 2017

Marianne Ernst

7

1 reference

Europe PubMed Central

14 August 2017

Johanna Zemva

8

1 reference

Europe PubMed Central

14 August 2017

Wilhelm Krone

10

1 reference

Europe PubMed Central

14 August 2017

Michael Udelhoven

11

1 reference

Europe PubMed Central

14 August 2017

Markus Schubert

12

1 reference

Europe PubMed Central

14 August 2017

publication date

6 November 2011

1 reference

Europe PubMed Central

14 August 2017

1 reference

Europe PubMed Central

14 August 2017

35

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Europe PubMed Central

14 August 2017

1

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Europe PubMed Central

14 August 2017

83-101

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Europe PubMed Central

14 August 2017

Protein homeostasis and aging in neurodegeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

30 September 2017

Molecular mechanisms of neurodegeneration in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

30 September 2017

Insulin-like growth factor-1 (IGF-1)-induced processing of amyloid-beta precursor protein (APP) and APP-like protein 2 is mediated by different metalloproteinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

30 September 2017

The relationship between Alzheimer's disease and diabetes: Type 3 diabetes?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

30 September 2017

Reduced IGF-1 signaling delays age-associated proteotoxicity in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

30 September 2017

Early-onset and robust amyloid pathology in a new homozygous mouse model of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

30 September 2017

BACE and gamma-secretase characterization and their sorting as therapeutic targets to reduce amyloidogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

30 September 2017

Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

30 September 2017

The role of metabolic disorders in Alzheimer disease and vascular dementia: two roads converged

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

30 September 2017

Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Abeta oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

30 September 2017

Brain IGF-1 receptors control mammalian growth and lifespan through a neuroendocrine mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

30 September 2017

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

30 September 2017

Efficient inhibition of the Alzheimer's disease beta-secretase by membrane targeting

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

30 September 2017

A brief introduction to FOXOlogy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

30 September 2017

A Foxo/Notch pathway controls myogenic differentiation and fiber type specification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

30 September 2017

Brain IRS2 signaling coordinates life span and nutrient homeostasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

30 September 2017

The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

30 September 2017

Aging of the brain, neurotrophin signaling, and Alzheimer's disease: is IGF1-R the common culprit?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

30 September 2017

IGF-1-induced processing of the amyloid precursor protein family is mediated by different signaling pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

30 September 2017

Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: relevance to Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

30 September 2017

APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

30 September 2017

Opposing activities protect against age-onset proteotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

30 September 2017

An aging pathway controls the TrkA to p75NTR receptor switch and amyloid beta-peptide generation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

30 September 2017

A specific amyloid-beta protein assembly in the brain impairs memory

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

30 September 2017

APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

30 September 2017

Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

30 September 2017

Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

30 September 2017

Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

30 September 2017

FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

30 September 2017

Mortality associated with Down's syndrome in the USA from 1983 to 1997: a population-based study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

30 September 2017

Alzheimer's disease and Down's syndrome: roles of APP, trophic factors and ACh.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

30 September 2017

Regulation of C. elegans life-span by insulinlike signaling in the nervous system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

30 September 2017

Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

30 September 2017

Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

30 September 2017

daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

30 September 2017

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

30 September 2017

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

30 September 2017

A C. elegans mutant that lives twice as long as wild type

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

30 September 2017

Temporal requirements of insulin/IGF-1 signaling for proteotoxicity protection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

28 June 2018

Epidermal insulin/IGF-1 signalling control interfollicular morphogenesis and proliferative potential through Rac activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

28 June 2018

Role of brain insulin receptor in control of body weight and reproduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

28 June 2018

Association of diabetes mellitus and dementia: the Rotterdam Study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

28 June 2018

Mortality of people with mental retardation in California with and without Down syndrome, 1986-1991.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

28 June 2018

Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

28 June 2018

PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response

1 reference

https://api.crossref.org/works/10.1007%2FS11357-011-9333-2

21 January 2018

Phenotype associated with APP duplication in five families.

1 reference

https://api.crossref.org/works/10.1007%2FS11357-011-9333-2

21 January 2018

Genetic modification of the phenotypes produced by amyloid precursor protein overexpression in transgenic mice.

1 reference

https://api.crossref.org/works/10.1007%2FS11357-011-9333-2

21 January 2018

Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695.

1 reference

https://api.crossref.org/works/10.1007%2FS11357-011-9333-2

21 January 2018

Mortality and causes of death in persons with Down syndrome in California

1 reference

https://api.crossref.org/works/10.1007%2FS11357-011-9333-2

21 January 2018

Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease.

1 reference

https://api.crossref.org/works/10.1007%2FS11357-011-9333-2

21 January 2018

Neuronal IGF-1 resistance reduces Abeta accumulation and protects against premature death in a model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1007%2FS11357-011-9333-2

21 January 2018

Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1007%2FS11357-011-9333-2

21 January 2018

A disturbance in the neuronal insulin receptor signal transduction in sporadic Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1007%2FS11357-011-9333-2

21 January 2018

Age-dependent neurodegeneration and Alzheimer-amyloid plaque formation in transgenic Drosophila.

1 reference

https://api.crossref.org/works/10.1007%2FS11357-011-9333-2

21 January 2018

Mortality and cancer incidence in persons with Down's syndrome, their parents and siblings

1 reference

https://api.crossref.org/works/10.1007%2FS11357-011-9333-2

21 January 2018

Spatial and temporal expression of FoxO transcription factors in the developing and adult murine brain.

1 reference

https://api.crossref.org/works/10.1007%2FS11357-011-9333-2

21 January 2018

Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins

1 reference

https://api.crossref.org/works/10.1007%2FS11357-011-9333-2

21 January 2018

Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway

1 reference

https://api.crossref.org/works/10.1007%2FS11357-011-9333-2

21 January 2018

Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death.

1 reference

https://api.crossref.org/works/10.1007%2FS11357-011-9333-2

21 January 2018

Diabetes and dementia: is the brain another site of end-organ damage?

1 reference

https://api.crossref.org/works/10.1007%2FS11357-011-9333-2

21 January 2018

Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS11357-011-9333-2

21 January 2018

Diabetes mellitus and the risk of dementia: The Rotterdam Study.

1 reference

https://api.crossref.org/works/10.1007%2FS11357-011-9333-2

21 January 2018

Alzheimer's disease could be "type 3 diabetes".

1 reference

https://api.crossref.org/works/10.1007%2FS11357-011-9333-2

21 January 2018

Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis

1 reference

https://api.crossref.org/works/10.1007%2FS11357-011-9333-2

21 January 2018

Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes?

1 reference

https://api.crossref.org/works/10.1007%2FS11357-011-9333-2

21 January 2018

Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

21 September 2018

Lack of neurodegeneration in transgenic mice overexpressing mutant amyloid precursor protein is associated with increased levels of transthyretin and the activation of cell survival pathways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543743

21 September 2018

Life expectancy in Down syndrome adults

1 reference

https://pubmed.ncbi.nlm.nih.gov/22057897

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The genetics of aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/22057897

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S11357-011-9333-2

1 reference

Europe PubMed Central

14 August 2017

1 reference

Europe PubMed Central

14 August 2017

1 reference

Europe PubMed Central

14 August 2017

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