(Q37598601)

21 August 2017

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title

BACE and gamma-secretase characterization and their sorting as therapeutic targets to reduce amyloidogenesis (English)

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21 August 2017

Neville Marks

1

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PubMed ID

19760173

21 August 2017

Martin J Berg

series ordinal

2

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21 August 2017

17 September 2009

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21 August 2017

Neurochemical Research

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21 August 2017

35

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21 August 2017

2

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21 August 2017

181-210

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https://scigraph.springernature.com/pub.10.1007/s11064-009-0054-1

21 August 2017

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cites work

Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations

1 reference

https://api.crossref.org/works/10.1007%2FS11064-009-0054-1

Neurodegenerative lysosomal disorders: a continuum from development to late age.

21 January 2018

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Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study.

21 January 2018

1 reference

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Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-009-0054-1

A synthetic peptide blocking the apolipoprotein E/beta-amyloid binding mitigates beta-amyloid toxicity and fibril formation in vitro and reduces beta-amyloid plaques in transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-009-0054-1

A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-009-0054-1

Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-009-0054-1

The search for gamma-secretase and development of inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-009-0054-1

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-009-0054-1

Chaperone-Mediated Autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-009-0054-1

Activation and functional characterization of the mosaic receptor SorLA/LR11.

21 January 2018

1 reference

12 December 2020

The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase

1 reference

12 December 2020

Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch

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12 December 2020

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

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12 December 2020

FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.

1 reference

12 December 2020

Loss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: evidence for a proximal role in Alzheimer's disease

1 reference

12 December 2020

The gamma-secretase complex: machinery for intramembrane proteolysis

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12 December 2020

Tumor necrosis factor-alpha converting enzyme is processed by proprotein-convertases to its mature form which is degraded upon phorbol ester stimulation

1 reference

12 December 2020

Enhanced amyloidogenic metabolism of the amyloid beta-protein precursor in the X11L-deficient mouse brain.

1 reference

12 December 2020

GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

1 reference

12 December 2020

Accelerated plaque accumulation, associative learning deficits, and up-regulation of alpha 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins

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12 December 2020

Presenilin 1 mediates retinoic acid-induced differentiation of SH-SY5Y cells through facilitation of Wnt signaling

1 reference

12 December 2020

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

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12 December 2020

The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts

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12 December 2020

In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.

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12 December 2020

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

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12 December 2020

Identification of syntaxin 1A as a novel binding protein for presenilin-1.

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12 December 2020

Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation.

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12 December 2020

Chromosome 13 dementias

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12 December 2020

Functional reconstitution of ESCRT-III assembly and disassembly

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12 December 2020

Membrane topology of gamma-secretase component PEN-2.

1 reference

12 December 2020

BACE1 (beta-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes

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12 December 2020

Purification and cloning of amyloid precursor protein beta-secretase from human brain

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12 December 2020

Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase

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12 December 2020

Amyloid precursor-like protein 1 influences endocytosis and proteolytic processing of the amyloid precursor protein

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12 December 2020

Blocking the cleavage at midportion between gamma- and epsilon-sites remarkably suppresses the generation of amyloid beta-protein.

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12 December 2020

Alzheimer amyloid precursor aspartyl proteinase activity in CHAPSO homogenates of Spodoptera frugiperda cells.

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12 December 2020

Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin

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12 December 2020

Probing pockets S2-S4' of the gamma-secretase active site with (hydroxyethyl)urea peptidomimetics

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12 December 2020

Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease

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12 December 2020

Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes

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12 December 2020

Regulation of gamma-secretase activity in Alzheimer's disease

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12 December 2020

Functional domains of the BACE1 and BACE2 promoters and mechanisms of transcriptional suppression of the BACE2 promoter in normal neuronal cells

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12 December 2020

Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein

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12 December 2020

Continuing strategies for inhibiting Alzheimer's gamma-secretase.

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12 December 2020

Reduction of Abeta levels in the Sprague Dawley rat after oral administration of the functional gamma-secretase inhibitor, DAPT: a novel non-transgenic model for Abeta production inhibitors

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12 December 2020

Novel approaches for immunotherapeutic intervention in Alzheimer's disease

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12 December 2020

Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity

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12 December 2020

Effects of a gamma-secretase inhibitor in a randomized study of patients with Alzheimer disease

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12 December 2020

The cysteine-rich domain regulates ADAM protease function in vivo

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12 December 2020

Human BACE forms dimers and colocalizes with APP.

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12 December 2020

Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex.

1 reference

12 December 2020

Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin

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12 December 2020

Reconstitution of gamma-secretase activity

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12 December 2020

Amyloid precursor protein trafficking, processing, and function

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12 December 2020

Loss of apolipoprotein E receptor LR11 in Alzheimer disease

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12 December 2020

The cytosolic loop of the gamma-secretase component presenilin enhancer 2 protects zebrafish embryos from apoptosis

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12 December 2020

In silico discovery of beta-secretase inhibitors.

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12 December 2020

Regulated proteolysis of the IFNaR2 subunit of the interferon-alpha receptor

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12 December 2020

Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism.

1 reference

12 December 2020

Identification of candidate substrates for ectodomain shedding by the metalloprotease-disintegrin ADAM8.

1 reference

12 December 2020

Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation

1 reference

12 December 2020

The role of the endosomal/lysosomal system in amyloid-beta production and the pathophysiology of Alzheimer's disease: reexamining the spatial paradox from a lysosomal perspective.

1 reference

12 December 2020

The presenilins turned inside out: implications for their structures and functions

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12 December 2020

Phosphoinositides suppress gamma-secretase in both the detergent-soluble and -insoluble states

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12 December 2020

Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response

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12 December 2020

Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons

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12 December 2020

Lipoprotein receptors in Alzheimer's disease

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12 December 2020

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

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12 December 2020

Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms

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12 December 2020

Rapid purification of active gamma-secretase, an intramembrane protease implicated in Alzheimer's disease

1 reference

12 December 2020

Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members

1 reference

12 December 2020

Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model.

1 reference

12 December 2020

Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration

1 reference

12 December 2020

Identification and characterization of a novel human APH-1b splice variant lacking exon 4

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12 December 2020

SnapShot: notch signaling pathway

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12 December 2020

Composition of white matter bovine brain coated vesicles: evidence that several components influence beta-amyloid peptide to form oligomers and aggregates in vitro.

1 reference

12 December 2020

LR11/SorLA expression is reduced in sporadic Alzheimer disease but not in familial Alzheimer disease

1 reference

12 December 2020

Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3beta phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimer's disease.

1 reference

12 December 2020

Generation of the β-Amyloid Peptide and the Amyloid Precursor Protein C-terminal Fragment γ Are Potentiated by FE65L1

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12 December 2020

The role of amyloid-beta derived diffusible ligands (ADDLs) in Alzheimer's disease

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12 December 2020

Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling

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12 December 2020

In vitro characterization of the presenilin-dependent gamma-secretase complex using a novel affinity ligand.

1 reference

12 December 2020

Tissue inhibitor of metalloproteinases-3 and matrix metalloproteinase-3 regulate neuronal sensitivity to doxorubicin-induced apoptosis

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12 December 2020

Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice

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12 December 2020

Demonstration of BACE (beta-secretase) phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy

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12 December 2020

The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate.

1 reference

12 December 2020

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

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12 December 2020

Linking receptor-mediated endocytosis and cell signaling: evidence for regulated intramembrane proteolysis of megalin in proximal tubule

1 reference

12 December 2020

Amyloid suppresses induction of genes critical for memory consolidation in APP + PS1 transgenic mice.

1 reference

12 December 2020

Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor

1 reference

12 December 2020

Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains

1 reference

12 December 2020

Regulated intramembrane proteolysis of the p75 neurotrophin receptor modulates its association with the TrkA receptor

1 reference

12 December 2020

Abeta42 overproduction associated with structural changes in the catalytic pore of gamma-secretase: common effects of Pen-2 N-terminal elongation and fenofibrate

1 reference

12 December 2020

Difluoro ketone peptidomimetics suggest a large S1 pocket for Alzheimer's gamma-secretase: implications for inhibitor design

1 reference

12 December 2020

Overexpression of calsenilin enhances gamma-secretase activity.

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12 December 2020

Amyloid precursor protein associates with a nicastrin-dependent docking site on the presenilin 1-gamma-secretase complex in cells demonstrated by fluorescence lifetime imaging.

1 reference

12 December 2020

Rat nicastrin gene: cDNA isolation, mRNA variants and expression pattern analysis

1 reference

12 December 2020

S-adenosyl methionine: A connection between nutritional and genetic risk factors for neurodegeneration in Alzheimer's disease.

1 reference

12 December 2020

Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation

1 reference

12 December 2020

Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase

1 reference

12 December 2020

The structure and functions of the presenilins

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12 December 2020

Abnormal expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in brain arteriovenous malformations

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12 December 2020

gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins

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12 December 2020

Regulatory roles of presenilin-1 and nicastrin in neuronal differentiation during in vitro neurogenesis

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12 December 2020

Synthesis of new 3-alkoxy-7-amino-4-chloro-isocoumarin derivatives as new beta-amyloid peptide production inhibitors and their activities on various classes of protease

1 reference

12 December 2020

Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production

1 reference

12 December 2020

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

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12 December 2020

Secretion of the Notch-1 Abeta-like peptide during Notch signaling

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12 December 2020

Induction of pro-apoptotic calsenilin/DREAM/KChIP3 in Alzheimer's disease and cultured neurons after amyloid-beta exposure.

1 reference

12 December 2020

Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's beta-secretase

1 reference

12 December 2020

PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein

1 reference

12 December 2020

A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease

1 reference

12 December 2020

BACE-2 is overexpressed in Down's syndrome.

1 reference

12 December 2020

Specificity of memapsin 1 and its implications on the design of memapsin 2 (beta-secretase) inhibitor selectivity

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12 December 2020

Degradation of BACE by the ubiquitin-proteasome pathway

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12 December 2020

Evidence for a six-transmembrane domain structure of presenilin 1.

1 reference

12 December 2020

Gamma-secretase activity is associated with a conformational change of nicastrin

1 reference

12 December 2020

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

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12 December 2020

beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase

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12 December 2020

The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons

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12 December 2020

Tandem MS analysis of brain clathrin-coated vesicles reveals their critical involvement in synaptic vesicle recycling

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12 December 2020

Loss of nicastrin elicits an apoptotic phenotype in mouse embryos.

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12 December 2020

Calorie restriction attenuates Alzheimer's disease type brain amyloidosis in Squirrel monkeys (Saimiri sciureus).

1 reference

12 December 2020

APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development

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12 December 2020

The ADAM gene family: surface proteins with adhesion and protease activity

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12 December 2020

The role of presenilin cofactors in the gamma-secretase complex

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12 December 2020

Transient abundance of presenilin 1 fragments/nicastrin complex associated with synaptogenesis during development in rat cerebellum.

1 reference

12 December 2020

Neuronal localization of the TNFalpha converting enzyme (TACE) in brain tissue and its correlation to amyloid plaques

1 reference

12 December 2020

X11 interaction with beta-amyloid precursor protein modulates its cellular stabilization and reduces amyloid beta-protein secretion

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12 December 2020

BACE (beta-secretase) modulates the processing of APLP2 in vivo

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12 December 2020

Presenilin 1 facilitates the constitutive turnover of beta-catenin: differential activity of Alzheimer's disease-linked PS1 mutants in the beta-catenin-signaling pathway

1 reference

12 December 2020

Aph-1 interacts at the cell surface with proteins in the active gamma-secretase complex and membrane-tethered Notch.

1 reference

12 December 2020

The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling

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12 December 2020

Presenilin-1 D257A and D385A mutants fail to cleave Notch in their endoproteolyzed forms, but only presenilin-1 D385A mutant can restore its gamma-secretase activity with the compensatory overexpression of normal C-terminal fragment

1 reference

12 December 2020

Cleavage of p75 neurotrophin receptor by alpha-secretase and gamma-secretase requires specific receptor domains

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12 December 2020

Nicastrin expression in mouse peripheral tissues is not co-ordinated with presenilin and is high in muscle

1 reference

12 December 2020

Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme

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12 December 2020

Design and synthesis of highly potent benzodiazepine gamma-secretase inhibitors: preparation of (2S,3R)-3-(3,4-difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-N-((3S)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1H-benzo[e][1,4]-diazepin-3-yl)butyramide by us

1 reference

12 December 2020

Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios.

1 reference

12 December 2020

Determination of guinea-pig cortical gamma-secretase activity ex vivo following the systemic administration of a gamma-secretase inhibitor

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12 December 2020

In vitro reconstitution of gamma-secretase activity using yeast microsomes

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12 December 2020

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha

1 reference

12 December 2020

Membrane topology of Alzheimer's disease-related presenilin 1. Evidence for the existence of a molecular species with a seven membrane-spanning and one membrane-embedded structure

1 reference

12 December 2020

gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease

1 reference

12 December 2020

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

1 reference

12 December 2020

Gleevec inhibits β-amyloid production but not Notch cleavage

1 reference

12 December 2020

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

1 reference

12 December 2020

Beta-amyloid precursor protein cleavage by a membrane-bound protease

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12 December 2020

Identification of neuronal plasma membrane microdomains that colocalize beta-amyloid and presenilin: implications for beta-amyloid precursor protein processing

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12 December 2020

Molecular machinery of autophagosome formation in yeast, Saccharomyces cerevisiae

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12 December 2020

Characterization of alpha 2,6-sialyltransferase cleavage by Alzheimer's beta -secretase (BACE1).

1 reference

12 December 2020

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

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12 December 2020

Characterization of the human beta-secretase 2 (BACE2) 5'-flanking region: identification of a 268-bp region as the basal BACE2 promoter

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12 December 2020

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

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12 December 2020

Implication of gamma-secretase in neuregulin-induced maturation of oligodendrocytes

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12 December 2020

Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria

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12 December 2020

The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region

1 reference

12 December 2020

The neuropeptide PACAP promotes the alpha-secretase pathway for processing the Alzheimer amyloid precursor protein

1 reference

12 December 2020

Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores

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12 December 2020

Purification and characterization of the human gamma-secretase complex

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12 December 2020

RAC1 inhibition targets amyloid precursor protein processing by gamma-secretase and decreases Abeta production in vitro and in vivo.

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12 December 2020

3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes

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12 December 2020

Protein kinase C epsilon suppresses Abeta production and promotes activation of alpha-secretase.

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12 December 2020

Inhibiting amyloid precursor protein C-terminal cleavage promotes an interaction with presenilin 1.

1 reference

12 December 2020

Presenilin 1 protein directly interacts with Bcl-2

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12 December 2020

Structure-activity relationship of hydroxamate-based inhibitors on the secretases that cleave the amyloid precursor protein, angiotensin converting enzyme, CD23, and pro-tumor necrosis factor-alpha

1 reference

12 December 2020

Ubiquilin regulates presenilin endoproteolysis and modulates gamma-secretase components, Pen-2 and nicastrin

1 reference

12 December 2020

Amyloid-lowering isocoumarins are not direct inhibitors of gamma-secretase

1 reference

12 December 2020

Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway

1 reference

12 December 2020

Lysosomes: fusion and function

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12 December 2020

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein

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12 December 2020

gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

1 reference

12 December 2020

Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation

1 reference

12 December 2020

Glucosylceramide synthase decrease in frontal cortex of Alzheimer brain correlates with abnormal increase in endogenous ceramides: consequences to morphology and viability on enzyme suppression in cultured primary neurons

1 reference

12 December 2020

Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1.

1 reference

12 December 2020

X11alpha impairs gamma- but not beta-cleavage of amyloid precursor protein.

1 reference

12 December 2020

Nonsteroidal Anti-Inflammatory Drugs Can Lower Amyloidogenic Aß 42 by Inhibiting Rho

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12 December 2020

Presenilin endoproteolysis is an intramolecular cleavage

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12 December 2020

Selective ectodomain phosphorylation and regulated cleavage of beta-amyloid precursor protein

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12 December 2020

[Specific suppression of beta-secretase gene expression by short interfering RNA in mammalian cells].

1 reference

12 December 2020

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

1 reference

12 December 2020

Abeta-generating enzymes: recent advances in beta- and gamma-secretase research

1 reference

12 December 2020

A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1.

1 reference

12 December 2020

C-terminal Fragment of Presenilin Is the Molecular Target of a Dipeptidic γ-Secretase-specific Inhibitor DAPT (N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycinet-Butyl Ester)

1 reference

12 December 2020

Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex

1 reference

12 December 2020

Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44.

1 reference

12 December 2020

gamma-Cleavage is dependent on zeta-cleavage during the proteolytic processing of amyloid precursor protein within its transmembrane domain

1 reference

12 December 2020

Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins

1 reference

12 December 2020

Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo

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12 December 2020

ADAM proteases: protective role in Alzheimer's and prion diseases?

1 reference

12 December 2020

Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1

1 reference

12 December 2020

Transcriptional regulation of PEN-2, a key component of the gamma-secretase complex, by CREB

1 reference

12 December 2020

Processing amyloid precursor protein at the beta-site requires proper orientation to be accessed by BACE1.

1 reference

12 December 2020

Direct visualization of the gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein: association with Fe65 and translocation to the nucleus

1 reference

12 December 2020

Secretase targets for Alzheimer's disease: identification and therapeutic potential

1 reference

12 December 2020

Gamma-secretase complex assembly within the early secretory pathway

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12 December 2020

Conserved residues within the putative active site of gamma-secretase differentially influence enzyme activity and inhibitor binding

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12 December 2020

Altered Abeta formation and long-term potentiation in a calsenilin knock-out

1 reference

12 December 2020

Association of active gamma-secretase complex with lipid rafts.

1 reference

12 December 2020

The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production

1 reference

12 December 2020

A non-amyloidogenic function of BACE-2 in the secretory pathway

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12 December 2020

C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation

1 reference

12 December 2020

gamma-secretase cleavage is distinct from endoplasmic reticulum degradation of the transmembrane domain of the amyloid precursor protein

1 reference

12 December 2020

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

1 reference

12 December 2020

Calpain-regulated p35/cdk5 plays a central role in dopaminergic neuron death through modulation of the transcription factor myocyte enhancer factor 2.

1 reference

12 December 2020

Comparative localization of ADAMs 10 and 15 in human cerebral cortex normal aging, Alzheimer disease and Down syndrome

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12 December 2020

Therapeutic benefits from targeting of ADAM family members

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12 December 2020

Conserved residues in juxtamembrane region of the extracellular domain of nicastrin are essential for gamma-secretase complex formation

1 reference

12 December 2020

Studies of Abeta pharmacodynamics in the brain, cerebrospinal fluid, and plasma in young (plaque-free) Tg2576 mice using the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[

1 reference

12 December 2020

Fenchylamine sulfonamide inhibitors of amyloid beta peptide production by the gamma-secretase proteolytic pathway: potential small-molecule therapeutic agents for the treatment of Alzheimer's disease

1 reference

12 December 2020

The protease inhibitor, MG132, blocks maturation of the amyloid precursor protein Swedish mutant preventing cleavage by beta-Secretase

1 reference

12 December 2020

Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4.

1 reference

12 December 2020

Mice lacking the metalloprotease-disintegrin MDC9 (ADAM9) have no evident major abnormalities during development or adult life.

1 reference

12 December 2020

APP processing and synaptic plasticity in presenilin-1 conditional knockout mice

1 reference

12 December 2020

Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin

1 reference

12 December 2020

Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin

1 reference

12 December 2020

Reductions in beta-amyloid concentrations in vivo by the gamma-secretase inhibitors BMS-289948 and BMS-299897.

1 reference

12 December 2020

Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions.

1 reference

12 December 2020

Elevated expression of beta-site amyloid precursor protein cleaving enzyme 2 in brains of patients with Down syndrome

1 reference

12 December 2020

Association of membrane-bound amyloid precursor protein APP with the apolipoprotein E receptor LRP.

1 reference

12 December 2020

Substrate and inhibitor profile of BACE (beta-secretase) and comparison with other mammalian aspartic proteases

1 reference

12 December 2020

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

1 reference

12 December 2020

Changes in gamma-secretase activity and specificity caused by the introduction of consensus aspartyl protease active motif in Presenilin 1.

1 reference

12 December 2020

Alzheimer's disease beta-amyloid peptides are released in association with exosomes

1 reference

12 December 2020

Long-chain ceramide is elevated in presenilin 1 (PS1M146V) mouse brain and induces apoptosis in PS1 astrocytes

1 reference

12 December 2020

Impas 1 possesses endoproteolytic activity against multipass membrane protein substrate cleaving the presenilin 1 holoprotein

1 reference

12 December 2020

Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model.

1 reference

12 December 2020

Cell-free assays for gamma-secretase activity

1 reference

12 December 2020

The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages: modulation of APLP-1 processing by n-glycosylation

1 reference

12 December 2020

Distinct secretases, a cysteine protease and a serine protease, generate the C termini of amyloid beta-proteins Abeta1-40 and Abeta1-42, respectively

1 reference

12 December 2020

NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo

1 reference

12 December 2020

Relationship between presenilinase and gamma-secretase.

1 reference

12 December 2020

A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase

1 reference

12 December 2020

The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate

1 reference

12 December 2020

Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport

1 reference

12 December 2020

Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels.

1 reference

12 December 2020

aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling

1 reference

12 December 2020

Beta-secretase processing of the Alzheimer's amyloid protein precursor (APP).

1 reference

12 December 2020

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

1 reference

12 December 2020

The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the gamma-secretase.

1 reference

12 December 2020

Beta-secretase cleavage at amino acid residue 34 in the amyloid beta peptide is dependent upon gamma-secretase activity

1 reference

12 December 2020

Effects of gamma-secretase cleavage-region mutations on APP processing and Abeta formation: interpretation with sequential cleavage and alpha-helical model

1 reference

12 December 2020

Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease

1 reference

12 December 2020

Conformational flexibility of beta-secretase: molecular dynamics simulation and essential dynamics analysis.

1 reference

12 December 2020

Immunoisolation of two synaptic vesicle pools from synaptosomes: a proteomics analysis

1 reference

12 December 2020

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

12 December 2020

Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage

1 reference

12 December 2020

Studies to investigate the in vivo therapeutic window of the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide (LY411,575) in the CRND8 mouse.

1 reference

12 December 2020

A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells

1 reference

12 December 2020

Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42.

1 reference

12 December 2020

Gamma-secretase is a functional component of phagosomes.

1 reference

12 December 2020

A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis.

1 reference

12 December 2020

The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity

1 reference

12 December 2020

Glycogen synthase kinase 3beta phosphorylation of microtubule-associated protein 1B regulates the stability of microtubules in growth cones.

1 reference

12 December 2020

L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity

1 reference

12 December 2020

Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1

1 reference

12 December 2020

Interaction of presenilins with FKBP38 promotes apoptosis by reducing mitochondrial Bcl-2.

1 reference

12 December 2020

Sequences from the low density lipoprotein receptor-related protein (LRP) cytoplasmic domain enhance amyloid beta protein production via the beta-secretase pathway without altering amyloid precursor protein/LRP nuclear signaling

1 reference

12 December 2020

The experimental Alzheimer's disease drug posiphen [(+)-phenserine] lowers amyloid-beta peptide levels in cell culture and mice.

1 reference

12 December 2020

Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology.

1 reference

12 December 2020

Identification of distinct gamma-secretase complexes with different APH-1 variants

1 reference

12 December 2020

Generation of beta A4 from the amyloid protein precursor and fragments thereof

1 reference

12 December 2020

The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins

1 reference

12 December 2020

Quantitative proteomics analysis of the secretory pathway

1 reference

12 December 2020

Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes

1 reference

12 December 2020

Glutamate Receptor Subunit 3 Is Modified by Site-specific Limited Proteolysis Including Cleavage by γ-Secretase

1 reference

12 December 2020

The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.

1 reference

12 December 2020

In vivo characterization of Abeta(40) changes in brain and cerebrospinal fluid using the novel gamma-secretase inhibitor N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) in the rat.

1 reference

12 December 2020

TOR signaling in growth and metabolism

1 reference

12 December 2020

Functional overexpression of gamma-secretase reveals protease-independent trafficking functions and a critical role of lipids for protease activity.

1 reference

12 December 2020

A role for calsenilin and related proteins in multiple aspects of neuronal function

1 reference

12 December 2020

Clearance of Alzheimer's Abeta peptide: the many roads to perdition.

1 reference

12 December 2020

The non-cyclooxygenase targets of non-steroidal anti-inflammatory drugs, lipoxygenases, peroxisome proliferator-activated receptor, inhibitor of kappa B kinase, and NF kappa B, do not reduce amyloid beta 42 production

1 reference

12 December 2020

Active gamma-secretase is localized to detergent-resistant membranes in human brain

1 reference

12 December 2020

Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase

1 reference

12 December 2020

Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735: a potential role in regulated shedding.

1 reference

12 December 2020

A Novel γ-Secretase Assay Based on Detection of the Putative C-terminal Fragment-γ of Amyloid β Protein Precursor

1 reference

12 December 2020

The biogenesis of multivesicular endosomes

1 reference

12 December 2020

Intracellular domains of amyloid precursor-like protein 2 interact with CP2 transcription factor in the nucleus and induce glycogen synthase kinase-3beta expression

1 reference

12 December 2020

Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1

1 reference

12 December 2020

Pathogenic mechanisms in Alzheimer's disease

1 reference

12 December 2020

Effect of mycelial extract of Clavicorona pyxidata on the production of amyloid beta-peptide and the inhibition of endogenous beta-secretase activity in vitro.

1 reference

12 December 2020

Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking

1 reference

12 December 2020

The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments

1 reference

12 December 2020

Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP

1 reference

12 December 2020

Flap position of free memapsin 2 (beta-secretase), a model for flap opening in aspartic protease catalysis

1 reference

12 December 2020

Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

1 reference

12 December 2020

The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex

1 reference

12 December 2020

Monoubiquitination and endocytosis direct gamma-secretase cleavage of activated Notch receptor

1 reference

12 December 2020

Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments.

1 reference

12 December 2020

Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity

1 reference

12 December 2020

Late endocytic dysfunction as a putative cause of amyloid fibril formation in Alzheimer's disease

1 reference

12 December 2020

Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme

1 reference

12 December 2020

Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy

1 reference

12 December 2020

Synergistic effects of Munc18a and X11 proteins on amyloid precursor protein metabolism

1 reference

12 December 2020

Autophagy gene-dependent clearance of apoptotic cells during embryonic development

1 reference

12 December 2020

Parallel synthesis of DAPT derivatives and their gamma-secretase-inhibitory activity

1 reference

12 December 2020

Regulation of Alzheimer's disease amyloid-beta formation by casein kinase I

1 reference

12 December 2020

Analysis of cholinergic markers, biogenic amines, and amino acids in the CNS of two APP overexpression mouse models

1 reference

12 December 2020

Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein

1 reference

12 December 2020

Supplementation with apple juice attenuates presenilin-1 overexpression during dietary and genetically-induced oxidative stress.

1 reference

12 December 2020

GGA proteins mediate the recycling pathway of memapsin 2 (BACE).

1 reference

12 December 2020

Contact-dependent inhibition of cortical neurite growth mediated by notch signaling

1 reference

12 December 2020

Gamma-secretase activity is present in rafts but is not cholesterol-dependent

1 reference

12 December 2020

Effects of RNAi-mediated silencing of PEN-2, APH-1a, and nicastrin on wild-type vs FAD mutant forms of presenilin 1.

1 reference

12 December 2020

Amyloid precursor protein is enriched in axolemma and periaxolemmal-myelin and associated clathrin-coated vesicles.

1 reference

12 December 2020

gamma-Secretase substrate selectivity can be modulated directly via interaction with a nucleotide-binding site

1 reference

12 December 2020

Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model

1 reference

12 December 2020

Stereoselective synthesis of photoreactive peptidomimetic gamma-secretase inhibitors

1 reference

12 December 2020

Nectin-1alpha, an immunoglobulin-like receptor involved in the formation of synapses, is a substrate for presenilin/gamma-secretase-like cleavage

1 reference

12 December 2020

1 reference

12 December 2020

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

1 reference

12 December 2020

Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen-2) demonstrate excessive p53-dependent apoptosis and neuronal loss

1 reference

12 December 2020

Spatial segregation of gamma-secretase and substrates in distinct membrane domains

1 reference

12 December 2020

Usefulness of behavioral and electrophysiological studies in transgenic models of Alzheimer's disease

1 reference

12 December 2020

Targeting BACE with small inhibitory nucleic acids - a future for Alzheimer's disease therapy?

1 reference

12 December 2020

Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation

1 reference

12 December 2020

Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides.

1 reference

12 December 2020

Growth hormone receptor is a target for presenilin-dependent gamma-secretase cleavage.

1 reference

12 December 2020

Expression of APP pathway mRNAs and proteins in Alzheimer's disease

1 reference

12 December 2020

Dynamics of {beta}-amyloid reductions in brain, cerebrospinal fluid, and plasma of {beta}-amyloid precursor protein transgenic mice treated with a {gamma}-secretase inhibitor

1 reference

12 December 2020

Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo

1 reference

12 December 2020

Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG

1 reference

12 December 2020

Amyloid beta inhibits ectodomain shedding of N-cadherin via down-regulation of cell-surface NMDA receptor.

1 reference

12 December 2020

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

1 reference

12 December 2020

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

1 reference

12 December 2020

Inhibitors of beta-amyloid formation based on the beta-secretase cleavage site

1 reference

12 December 2020

Direct and potent regulation of gamma-secretase by its lipid microenvironment

1 reference

12 December 2020

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

1 reference

12 December 2020

Structural locations and functional roles of new subsites S5, S6, and S7 in memapsin 2 (beta-secretase).

1 reference

12 December 2020

High affinity, bioavailable 3-Amino-1,4-benzodiazepine-Based γ-Secretase inhibitors

1 reference

12 December 2020

Evidence that the "NF" motif in transmembrane domain 4 of presenilin 1 is critical for binding with PEN-2.

1 reference

12 December 2020

Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for beta-amyloid peptide over-production and localization in Alzheimer's disease

1 reference

12 December 2020

RNA interference-mediated silencing of X11alpha and X11beta attenuates amyloid beta-protein levels via differential effects on beta-amyloid precursor protein processing.

1 reference

12 December 2020

A nine-transmembrane domain topology for presenilin 1

1 reference

12 December 2020

The various aggregation states of beta-amyloid 1-42 mediate different effects on oxidative stress, neurodegeneration, and BACE-1 expression

1 reference

12 December 2020

Insights into the phosphoregulation of beta-secretase sorting signal by the VHS domain of GGA1.

1 reference

12 December 2020

Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components

1 reference

12 December 2020

M<sub>1</sub> Muscarinic Agonists Can Modulate Some of the Hallmarks in Alzheimer's Disease: Implications in Future Therapy

1 reference

12 December 2020

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

1 reference

12 December 2020

The functions of mammalian amyloid precursor protein and related amyloid precursor-like proteins

1 reference

12 December 2020

Rab11a and HSP90 regulate recycling of extracellular alpha-synuclein

1 reference

12 December 2020

Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model

1 reference

12 December 2020

Structural classification of toxic amyloid oligomers

1 reference

12 December 2020

Molecular anatomy of a trafficking organelle

1 reference

12 December 2020

SorLA signaling by regulated intramembrane proteolysis

1 reference

12 December 2020

Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain

1 reference

12 December 2020

Caveolin-3 upregulation activates beta-secretase-mediated cleavage of the amyloid precursor protein in Alzheimer's disease.

1 reference

12 December 2020

Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel gamma-secretase substrates

1 reference

12 December 2020

Presenilin endoproteolysis mediated by an aspartyl protease activity pharmacologically distinct from gamma-secretase

1 reference

12 December 2020

The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage

1 reference

12 December 2020

Internalization of exogenously added memapsin 2 (beta-secretase) ectodomain by cells is mediated by amyloid precursor protein

1 reference

12 December 2020

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

1 reference

12 December 2020

Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin

1 reference

12 December 2020

gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity

1 reference

12 December 2020

Tenuigenin treatment decreases secretion of the Alzheimer's disease amyloid beta-protein in cultured cells

1 reference

12 December 2020

Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).

1 reference

12 December 2020

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

1 reference

12 December 2020

Activity of alpha-secretase as the common final effector of protein kinase C-dependent and -independent modulation of amyloid precursor protein metabolism

1 reference

12 December 2020

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

1 reference

12 December 2020

Down syndrome fibroblast model of Alzheimer-related endosome pathology: accelerated endocytosis promotes late endocytic defects

1 reference

12 December 2020

Inhibition of gamma-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes.

1 reference

12 December 2020

Modulation of microglial activation state following passive immunization in amyloid depositing transgenic mice

1 reference

12 December 2020

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

1 reference

12 December 2020

Three novel alternatively spliced isoforms of the human beta-site amyloid precursor protein cleaving enzyme (BACE) and their effect on amyloid beta-peptide production

1 reference

12 December 2020

Therapeutic potential and strategies for inhibiting tumor necrosis factor-alpha

1 reference

12 December 2020

A novel RNAi library based on partially randomized consensus sequences of nuclear receptors: identifying the receptors involved in amyloid beta degradation

1 reference

12 December 2020

Forebrain degeneration and ventricle enlargement caused by double knockout of Alzheimer's presenilin-1 and presenilin-2

1 reference

12 December 2020

Retromer sorting: a pathogenic pathway in late-onset Alzheimer disease

1 reference

12 December 2020

Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons

1 reference

12 December 2020

AF150(S) and AF267B: M1 muscarinic agonists as innovative therapies for Alzheimer's disease

1 reference

12 December 2020

Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes

1 reference

12 December 2020

The endoplasmic reticulum stress-responsive protein GRP78 protects neurons against excitotoxicity and apoptosis: suppression of oxidative stress and stabilization of calcium homeostasis.

1 reference

12 December 2020

The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor

1 reference

12 December 2020

Tau-dependent microtubule disassembly initiated by prefibrillar beta-amyloid

1 reference

12 December 2020

Identification of membrane-bound carbonic anhydrase in white matter coated vesicles: the fate of carbonic anhydrase and other white matter coated vesicle proteins in triethyl tin-induced leukoencephalopathy.

1 reference

12 December 2020

Release of a membrane-bound death domain by gamma-secretase processing of the p75NTR homolog NRADD

1 reference

12 December 2020

The disulphide bonds in the catalytic domain of BACE are critical but not essential for amyloid precursor protein processing activity

1 reference

12 December 2020

Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct.

1 reference

12 December 2020

TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity

1 reference

12 December 2020

Autophagy in the Pathogenesis of Disease

1 reference

12 December 2020

Caspase cleaved presenilin-1 is part of active gamma-secretase complexes

1 reference

12 December 2020

Targeting Alzheimer's disease genes with RNA interference: an efficient strategy for silencing mutant alleles

1 reference

12 December 2020

BACE2 functions as an alternative alpha-secretase in cells

1 reference

12 December 2020

Potential Link between Amyloid β-Protein 42 and C-terminal Fragment γ 49–99 of β-Amyloid Precursor Protein

1 reference

12 December 2020

Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase

1 reference

12 December 2020

Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase

1 reference

12 December 2020

Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid beta-protein.

1 reference

12 December 2020

Brain cathepsin B but not metalloendopeptidases degrade rAPP751 with production of amyloidogenic fragments. Comparison with synthetic peptides emulating beta- and gamma-secretase sites

1 reference

12 December 2020

Hydroxytriamides as potent gamma-secretase inhibitors

1 reference

12 December 2020

Partial Purification and Characterization of γ-Secretase from Post-mortem Human Brain

1 reference

12 December 2020

Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers

1 reference

12 December 2020

Phorbol 12-myristate 13-acetate-induced release of the colony-stimulating factor 1 receptor cytoplasmic domain into the cytosol involves two separate cleavage events

1 reference

12 December 2020

Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease

1 reference

12 December 2020

Phosphorylation regulates intracellular trafficking of beta-secretase

1 reference

12 December 2020

RNA interference silencing of the adaptor molecules ShcC and Fe65 differentially affect amyloid precursor protein processing and Abeta generation

1 reference

12 December 2020

CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production

1 reference

12 December 2020

gamma-Secretase-mediated release of the low density lipoprotein receptor-related protein 1B intracellular domain suppresses anchorage-independent growth of neuroglioma cells

1 reference

12 December 2020

Presenilin/gamma-secretase-mediated cleavage of the voltage-gated sodium channel beta2-subunit regulates cell adhesion and migration

1 reference

12 December 2020

Mechanism of gamma-secretase cleavage activation: is gamma-secretase regulated through autoinhibition involving the presenilin-1 exon 9 loop?

1 reference

12 December 2020

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

1 reference

12 December 2020

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1 reference

12 December 2020

Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD)

1 reference

12 December 2020

Inactivating mutations block the tumor necrosis factor-alpha-converting enzyme in the early secretory pathway.

1 reference

12 December 2020

Gene structure and organization of the human beta-secretase (BACE) promoter.

1 reference

12 December 2020

Capacitative calcium entry induces hippocampal long term potentiation in the absence of presenilin-1.

1 reference

12 December 2020

The presenilin-2 loop peptide perturbs intracellular Ca2+ homeostasis and accelerates apoptosis

1 reference

12 December 2020

Uncovering gamma-secretase

1 reference

12 December 2020

The presenilin proteins are components of multiple membrane-bound complexes that have different biological activities

1 reference

12 December 2020

The ADAMs family of metalloproteases: multidomain proteins with multiple functions

1 reference

12 December 2020

Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines

1 reference

12 December 2020

GSK-3 phosphorylation of the Alzheimer epitope within collapsin response mediator proteins regulates axon elongation in primary neurons.

1 reference

12 December 2020

A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response

1 reference

12 December 2020

Characterization of the reconstituted gamma-secretase complex from Sf9 cells co-expressing presenilin 1, nicastrin [correction of nacastrin], aph-1a, and pen-2.

1 reference

12 December 2020

(S)-N-(5-Chlorothiophene-2-sulfonyl)-beta,beta-diethylalaninol a Notch-1-sparing gamma-secretase inhibitor

1 reference

12 December 2020

BACE1 Suppression by RNA Interference in Primary Cortical Neurons

1 reference

12 December 2020

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

1 reference

12 December 2020

The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65.

1 reference

12 December 2020

A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.

1 reference

12 December 2020

The carboxyl termini of beta-amyloid peptides 1-40 and 1-42 are generated by distinct gamma-secretase activities

1 reference

12 December 2020

Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice.

1 reference

12 December 2020

Activated Notch1 associates with a presenilin‐1/γ‐secretase docking site

1 reference

12 December 2020

Endogenous beta-amyloid production in presenilin-deficient embryonic mouse fibroblasts

1 reference

12 December 2020

Genetic and molecular aspects of Alzheimer's disease shed light on new mechanisms of transcriptional regulation.

1 reference

12 December 2020

Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

1 reference

12 December 2020

Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease

1 reference

12 December 2020

Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

1 reference

12 December 2020

Topology of the C-terminal fragment of human presenilin 1.

1 reference

12 December 2020

The role of macroautophagy in the ageing process, anti-ageing intervention and age-associated diseases

1 reference

12 December 2020

The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments

1 reference

12 December 2020

Calcium binding sequences in calmyrin regulates interaction with presenilin-2

1 reference

12 December 2020

Autophagic stress in neuronal injury and disease.

1 reference

12 December 2020

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

1 reference

12 December 2020

BACE is degraded via the lysosomal pathway

1 reference

12 December 2020

Alzheimer's amyloid precursor protein alpha-secretase is inhibited by hydroxamic acid-based zinc metalloprotease inhibitors: similarities to the angiotensin converting enzyme secretase

1 reference

12 December 2020

Constitutive alpha-secretase cleavage of the beta-amyloid precursor protein in the furin-deficient LoVo cell line: involvement of the pro-hormone convertase 7 and the disintegrin metalloprotease ADAM10.

1 reference

12 December 2020

Levels of beta-secretase BACE and alpha-secretase ADAM10 mRNAs in Alzheimer hippocampus

1 reference

12 December 2020

Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology

1 reference

12 December 2020

No association of vacuolar protein sorting 26 polymorphisms with Alzheimer's disease

1 reference

12 December 2020

BACE1 interacts with nicastrin

1 reference

12 December 2020

New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage

1 reference

12 December 2020

Syndecan 3 intramembrane proteolysis is presenilin/gamma-secretase-dependent and modulates cytosolic signaling

1 reference

12 December 2020

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

1 reference

12 December 2020

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

1 reference

12 December 2020

Functional implications of the presenilin dimerization: reconstitution of gamma-secretase activity by assembly of a catalytic site at the dimer interface of two catalytically inactive presenilins

1 reference

12 December 2020

Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides.

1 reference

12 December 2020

A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations

1 reference

12 December 2020

10.1007/S11064-009-0054-1

Identifiers

DOI

1 reference

21 August 2017

1 reference

PubMed ID

19760173