(Q40441385)

English

Presenilin-1 D257A and D385A mutants fail to cleave Notch in their endoproteolyzed forms, but only presenilin-1 D385A mutant can restore its gamma-secretase activity with the compensatory overexpression of normal C-terminal fragment

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scholarly article

1 reference

Europe PubMed Central

20 September 2017

Presenilin-1 D257A and D385A mutants fail to cleave Notch in their endoproteolyzed forms, but only presenilin-1 D385A mutant can restore its gamma-secretase activity with the compensatory overexpression of normal C-terminal fragment (English)

1 reference

Europe PubMed Central

20 September 2017

1 reference

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author name string

Hangun Kim

1

1 reference

Europe PubMed Central

20 September 2017

Hyunkyoung Ki

2

1 reference

Europe PubMed Central

20 September 2017

Hee-Sae Park

3

1 reference

Europe PubMed Central

20 September 2017

Kwonseop Kim

4

1 reference

Europe PubMed Central

20 September 2017

language of work or name

0 references

publication date

29 March 2005

1 reference

Europe PubMed Central

20 September 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

20 September 2017

280

1 reference

Europe PubMed Central

20 September 2017

23

1 reference

Europe PubMed Central

20 September 2017

22462-22472

1 reference

Europe PubMed Central

20 September 2017

Presenilins and Alzheimer's disease: biological functions and pathogenic mechanisms

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

Presenilin mutations in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

Gamma-secretase activity is associated with a conformational change of nicastrin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

Mechanism of gamma-secretase cleavage activation: is gamma-secretase regulated through autoinhibition involving the presenilin-1 exon 9 loop?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

Mutation of conserved aspartates affects maturation of both aspartate mutant and endogenous presenilin 1 and presenilin 2 complexes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

PS1 N- and C-terminal fragments form a complex that functions in APP processing and Notch signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

The aspartate-257 of presenilin 1 is indispensable for mouse development and production of beta-amyloid peptides through beta-catenin-independent mechanisms

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

Reconstitution of gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

Pen-2 is sequestered in the endoplasmic reticulum and subjected to ubiquitylation and proteasome-mediated degradation in the absence of presenilin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

The role of presenilin cofactors in the gamma-secretase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

Effects of PS1 deficiency on membrane protein trafficking in neurons.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

Presenilin is required for activity and nuclear access of Notch in Drosophila

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

Where Notch and Wnt signaling meet. The presenilin hub

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

The notch intracellular domain can function as a coactivator for LEF-1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

Phosphorylation of presenilin 1 at the caspase recognition site regulates its proteolytic processing and the progression of apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

The C-terminal fragment of presenilin 2 triggers p53-mediated staurosporine-induced apoptosis, a function independent of the presenilinase-derived N-terminal counterpart

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

The extreme C terminus of presenilin 1 is essential for gamma-secretase complex assembly and activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

The biological and pathological function of the presenilin-1 Deltaexon 9 mutation is independent of its defect to undergo proteolytic processing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

Functional domains in presenilin 1: the Tyr-288 residue controls gamma-secretase activity and endoproteolysis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

The mechanism of gamma-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

The presenilin proteins are components of multiple membrane-bound complexes that have different biological activities

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

The gamma-secretase complex: machinery for intramembrane proteolysis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502769200

21 January 2018

Identifiers

10.1074/JBC.M502769200

1 reference

Europe PubMed Central

20 September 2017

1 reference

Europe PubMed Central

20 September 2017

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