(Q40623499)

22 September 2017

Phosphorylation of presenilin 1 at the caspase recognition site regulates its proteolytic processing and the progression of apoptosis (English)

1 reference

22 September 2017

1 reference

1 reference

3

Christian Haass

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Arno Friedlein

series ordinal

2

object named as

Arno Friedlein

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Regina Fluhrer

series ordinal

1

object named as

Regina Fluhrer

1 reference

22 September 2017

Arno Friedlein

2

1 reference

PubMed ID

14576165

22 September 2017

Jochen Walter

series ordinal

4

1 reference

PubMed ID

14576165

22 September 2017

language of work or name

English

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publication date

22 October 2003

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Journal of Biological Chemistry

22 September 2017

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22 September 2017

279

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22 September 2017

1585-1593

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22 September 2017

3

1 reference

Apoptosis in neurodegenerative disorders

22 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

The cell biology of Alzheimer's disease: uncovering the secrets of secretases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Intramembrane proteolysis by presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

The role of A beta 42 in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Effects of PS1 deficiency on membrane protein trafficking in neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Presenilin 1 independently regulates beta-catenin stability and transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Inhibition of presenilin 1 expression is promoted by p53 and p21WAF-1 and results in apoptosis and tumor suppression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Alzheimer's disease associated presenilin-1 holoprotein and its 18-20 kDa C-terminal fragment are death substrates for proteases of the caspase family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Presenilins are processed by caspase-type proteases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Pro-apoptotic effect of presenilin 2 (PS2) overexpression is associated with down-regulation of Bcl-2 in cultured neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Increased apoptosis arising from increased expression of the Alzheimer's disease-associated presenilin-2 mutation (N141I).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Mechanisms of neuronal degeneration in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Proteolytic fragments of the Alzheimer's disease associated presenilins-1 and -2 are phosphorylated in vivo by distinct cellular mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Amyloid beta-peptide is produced by cultured cells during normal metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Comparison of cellular and nuclear flow cytometric techniques for discriminating apoptotic subpopulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Evidence for phosphorylation and oligomeric assembly of presenilin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Substitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Serine/threonine protein kinases and apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Cyclin-dependent kinase-5/p35 phosphorylates Presenilin 1 to regulate carboxy-terminal fragment stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Kinases: positive and negative regulators of apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Protein kinase A-Ialpha subunit-directed antisense inhibition of ovarian cancer cell growth: crosstalk with tyrosine kinase signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced abeta 42 production mediated by familial early onset Alzheimer's disease-linked PS variants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Phosphorylation of bid by casein kinases I and II regulates its cleavage by caspase 8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Phosphorylation of IkappaB-alpha inhibits its cleavage by caspase CPP32 in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

Presenilin-mediated modulation of capacitative calcium entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306653200

21 January 2018

Identifiers

DOI

10.1074/JBC.M306653200

1 reference

22 September 2017

1 reference

PubMed ID

14576165