(Q40513581)

21 September 2017

title

Nicastrin expression in mouse peripheral tissues is not co-ordinated with presenilin and is high in muscle (English)

1 reference

21 September 2017

3

Colin L Masters

1 reference

21 September 2017

Nancy T Ilaya

1

1 reference

21 September 2017

Geneviève Evin

series ordinal

2

1 reference

21 September 2017

Janetta G Culvenor

series ordinal

4

1 reference

21 September 2017

language of work or name

English

0 references

publication date

1 October 2004

1 reference

Journal of Neurochemistry

21 September 2017

number of pages

8

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based on heuristic

inferred from page(s)

published in

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21 September 2017

volume

91

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21 September 2017

issue

1

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21 September 2017

page(s)

230-237

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Endogenous beta-amyloid production in presenilin-deficient embryonic mouse fibroblasts

21 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

Nicastrin is a resident lysosomal membrane protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

In vitro characterization of the presenilin-dependent gamma-secretase complex using a novel affinity ligand.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

Lysosome-associated membrane proteins: characterization of LAMP-1 of macrophage P388 and mouse embryo 3T3 cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

Presenilin 2 expression in neuronal cells: induction during differentiation of embryonic carcinoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

Oligodendrocytes from neural stem cells express alpha-synuclein: increased numbers from presenilin 1 deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

Reconstitution of gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

At the acidic edge: emerging functions for lysosomal membrane proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

Wild-type and mutated nicastrins do not display aminopeptidase M- and B-like activities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

Differential expression of the lysosome-associated membrane proteins in normal human tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

Assembly and activation of the γ-secretase complex: roles of presenilin cofactors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

Intracellular accumulation of detergent-soluble amyloidogenic A beta fragment of Alzheimer's disease precursor protein in the hippocampus of aged transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

Refining structural and functional predictions for secretasome components by comparative sequence analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

Expression profiling of lymphocyte plasma membrane proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

Localization of presenilin-nicastrin complexes and gamma-secretase activity to the trans-Golgi network

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

The role of presenilin cofactors in the gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

Identification of signal peptide peptidase, a presenilin-type aspartic protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

Presenilins are not required for A beta 42 production in the early secretory pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

Nicastrin, a presenilin-interacting protein, contains an aminopeptidase/transferrin receptor superfamily domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02718.X

10.1111/J.1471-4159.2004.02718.X

21 January 2018

Identifiers

DOI

1 reference

21 September 2017

1 reference