(Q44485780)

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Synthesis of new 3-alkoxy-7-amino-4-chloro-isocoumarin derivatives as new beta-amyloid peptide production inhibitors and their activities on various classes of protease

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scholarly article

1 reference

Europe PubMed Central

3 December 2017

Synthesis of new 3-alkoxy-7-amino-4-chloro-isocoumarin derivatives as new beta-amyloid peptide production inhibitors and their activities on various classes of protease (English)

1 reference

Europe PubMed Central

3 December 2017

Cristine Alves da Costa

5

1 reference

Europe PubMed Central

3 December 2017

Olivier Pourquie

6

1 reference

Europe PubMed Central

3 December 2017

Frédéric Checler

7

1 reference

Europe PubMed Central

3 December 2017

Frédéric Bihel

1

object named as

Frédéric Bihel

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Hugues Lelouard

object named as

Hugues Lelouard

3

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Frédéric Bihel

object named as

Frédéric Bihel

1

0 references

Philippe Pierre

object named as

Philippe Pierre

9

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author name string

Gilles Quéléver

2

1 reference

Europe PubMed Central

3 December 2017

Agnès Petit

4

1 reference

Europe PubMed Central

3 December 2017

Annie Thellend

8

1 reference

Europe PubMed Central

3 December 2017

Jean Louis Kraus

10

1 reference

Europe PubMed Central

3 December 2017

language of work or name

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publication date

1 July 2003

1 reference

Europe PubMed Central

3 December 2017

Bioorganic & Medicinal Chemistry

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Europe PubMed Central

3 December 2017

11

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Europe PubMed Central

3 December 2017

14

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Europe PubMed Central

3 December 2017

3141-3152

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Europe PubMed Central

3 December 2017

Protease inhibitors: current status and future prospects

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Tipranavir (PNU-140690): A Potent, Orally Bioavailable Nonpeptidic HIV Protease Inhibitor of the 5,6-Dihydro-4-hydroxy-2-pyrone Sulfonamide Class∇

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Coumarins isolated from Angelica gigas inhibit acetylcholinesterase: structure-activity relationships

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Synthesis of an elaborated heliquinomycin isocoumarin moiety

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Mechanism-based isocoumarin inhibitors for blood coagulation serine proteases. Effect of the 7-substituent in 7-amino-4-chloro-3-(isothioureidoalkoxy)isocoumarins on inhibitory and anticoagulant potency

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6-Substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid as a core structure for specific inhibitors of human leukocyte elastase

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Esters and amides of 6-(chloromethyl)-2-oxo-2H-1-benzopyran-3-carboxylic acid as inhibitors of alpha-chymotrypsin: significance of the "aromatic" nature of the novel ester-type coumarin for strong inhibitory activity

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Effect of the 7-amino substituent on the inhibitory potency of mechanism-based isocoumarin inhibitors for porcine pancreatic and human neutrophil elastases: a 1.85-A X-ray structure of the complex between porcine pancreatic elastase and 7-[(N-tosylp

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New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage

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Secretase targets for Alzheimer's disease: identification and therapeutic potential

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Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).

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Amyloid-lowering isocoumarins are not direct inhibitors of gamma-secretase

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Characterization of new polyclonal antibodies specific for 40 and 42 amino acid-long amyloid beta peptides: their use to examine the cell biology of presenilins and the immunohistochemistry of sporadic Alzheimer's disease and cerebral amyloid angiop

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Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 --> Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease

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A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.

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Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

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Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

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Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

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Structure-based design of HIV protease inhibitors: 4-hydroxycoumarins and 4-hydroxy-2-pyrones as non-peptidic inhibitors

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Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis

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Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation

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The amyloidogenic pathway of amyloid precursor protein (APP) is independent of its cleavage by caspases

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Intracellular targeting of the proteasome

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Production and characterization of monoclonal antibodies specific to multi-ubiquitin chains of polyubiquitinated proteins

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A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

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Presenilins: structural aspects and posttranslational events.

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On the size of the active site in proteases. I. Papain

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Alzheimer's disease: correlation of the suppression of beta-amyloid peptide secretion from cultured cells with inhibition of the chymotrypsin-like activity of the proteasome.

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Transient aggregation of ubiquitinated proteins during dendritic cell maturation

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Identifiers

10.1016/S0968-0896(03)00235-9

1 reference

Europe PubMed Central

3 December 2017

1 reference

Europe PubMed Central

3 December 2017

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