(Q46968608)

26 December 2017

title

The cytosolic loop of the gamma-secretase component presenilin enhancer 2 protects zebrafish embryos from apoptosis (English)

1 reference

26 December 2017

Presenilin enhancer, gamma-secretase subunit

main subject

1 reference

V-rel avian reticuloendotheliosis viral oncogene homolog A

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

1

Henrik Zetterberg

1 reference

26 December 2017

William A Campbell

2

1 reference

26 December 2017

Hong Wei Yang

series ordinal

3

1 reference

26 December 2017

Weiming Xia

series ordinal

4

1 reference

26 December 2017

language of work or name

English

0 references

publication date

28 February 2006

1 reference

26 December 2017

Journal of Biological Chemistry

published in

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26 December 2017

volume

281

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26 December 2017

issue

17

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26 December 2017

page(s)

11933-11939

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26 December 2017

Amyloid metabolism and secretases in Alzheimer's disease

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

The role of presenilin cofactors in the gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

Reconstitution of gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

Notch signaling: cell fate control and signal integration in development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

Notch and presenilin: a proteolytic mechanism emerges

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

A common enzyme connects notch signaling and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

Intramembrane proteolysis by presenilin and presenilin-like proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

Effects of RNA interference-mediated silencing of gamma-secretase complex components on cell sensitivity to caspase-3 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

Length and overall sequence of the PEN-2 C-terminal domain determines its function in the stabilization of presenilin fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

Neuroprotection by the inhibition of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

Mechanisms and genes of cellular suicide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

Activation of apoptosis and caspase-3 in zebrafish early gastrulae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

Cancer. p53, guardian of the genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

p53 in signaling checkpoint arrest or apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

p53 mutations in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

Control of apoptosis by Rel/NF-kappaB transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

Characterization of NF-kappa B/I kappa B proteins in zebra fish and their involvement in notochord development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

A novel NF-kappaB pathway involving IKKbeta and p65/RelA Ser-536 phosphorylation results in p53 Inhibition in the absence of NF-kappaB transcriptional activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

HTLV-I Tax induces a novel interaction between p65/RelA and p53 that results in inhibition of p53 transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen-2) demonstrate excessive p53-dependent apoptosis and neuronal loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

Stages of embryonic development of the zebrafish

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

Induction of a Common Pathway of Apoptosis by Staurosporine

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

Prediction of transmembrane alpha-helices in prokaryotic membrane proteins: the dense alignment surface method

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

Zebrafish as an experimental model: strategies for developmental and molecular neurobiology studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

Nicastrin functions as a gamma-secretase-substrate receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

NF-kappa B RelA (p65) is essential for TNF-alpha-induced fas expression but dispensable for both TCR-induced expression and activation-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-kappa B and AP-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

Reovirus-induced apoptosis requires activation of transcription factor NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) up-regulates death receptor 5 (DR5) mediated by NFkappaB activation in epithelial derived cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

NF-kappaB signaling pathway governs TRAIL gene expression and human T-cell leukemia virus-I Tax-induced T-cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512521200

21 January 2018

Identifiers

DOI

10.1074/JBC.M512521200

1 reference

26 December 2017

1 reference

26 December 2017