(Q34360633)

1 August 2017

1 reference

title

Notch and presenilin: a proteolytic mechanism emerges (English)

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1 August 2017

1 reference

Fortini ME

1

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1 August 2017

1 October 2001

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Current Opinion in Cell Biology

1 August 2017

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1 August 2017

13

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1 August 2017

627-634

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1 August 2017

5

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

1 August 2017

1 reference

7 January 2021

The world according to hedgehog

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Ci: a complex transducer of the hedgehog signal

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Signal transduction by a protease cascade

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Notch signaling: cell fate control and signal integration in development

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

The ins and outs of notch signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Notch: neurogenesis is only part of the picture

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Structure/function studies of lin-12/Notch proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

1 reference

7 January 2021

Intramembrane proteolysis by presenilins

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Effects of PS1 deficiency on membrane protein trafficking in neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Presenilins, processing of beta-amyloid precursor protein, and notch signaling.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

A common enzyme connects notch signaling and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel-12 and hop-1 in Notch-pathway signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Presenilin is required for activity and nuclear access of Notch in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Skeletal and CNS defects in Presenilin-1-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Mice lacking both presenilin genes exhibit early embryonic patterning defects

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Lack of requirement for presenilin1 in Notch1 signaling.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Characterization of Drosophila Presenilin and its colocalization with Notch during development.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

The Notch1 receptor is cleaved constitutively by a furin-like convertase

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Calcium depletion dissociates and activates heterodimeric notch receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

KUZ, a conserved metalloprotease-disintegrin protein with two roles in Drosophila neurogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Processing of the notch ligand delta by the metalloprotease Kuzbanian

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Requirement for dynamin during Notch signaling in Drosophila neurogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Mutation of the conserved N-terminal cysteine (Cys92) of human presenilin 1 causes increased A beta42 secretion in mammalian cells but impaired Notch/lin-12 signalling in C. elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Ligand-induced signaling in the absence of furin processing of Notch1.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Presenilin affects arm/beta-catenin localization and function in Drosophila.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Evidence that an IRES within the Notch2 coding region can direct expression of a nuclear form of the protein

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Requirement for presenilin 1 in facilitating lagged 2-mediated endoproteolysis and signaling of notch 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Effect of PS1 deficiency and an APP gamma-secretase inhibitor on Notch1 signaling in primary mammalian neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Notch-1 activation by familial Alzheimer's disease (FAD)-linked mutant forms of presenilin-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

Nicastrin binds to membrane-tethered Notch

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900261-1

7 January 2021

10.1016/S0955-0674(00)00261-1

Identifiers

DOI

1 reference

1 August 2017

1 reference

PubMed ID

11544033