(Q46652686)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16103123%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

title

Gamma-secretase is a functional component of phagosomes (English)

1 reference

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5 January 2020

3

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5 January 2020

author name string

Isabelle Jutras

1

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5 January 2020

Annie Laplante

2

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5 January 2020

Sylvain Brunet

4

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5 January 2020

Gopal Thinakaran

5

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5 January 2020

Michel Desjardins

6

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5 January 2020

language of work or name

English

0 references

publication date

15 August 2005

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16103123%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

5 January 2020

published in

1 reference

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5 January 2020

volume

280

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5 January 2020

issue

43

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5 January 2020

page(s)

36310-36317

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16103123%20AND%20SRC:MED&resulttype=core&format=json

Intramembrane proteolysis by presenilin and presenilin-like proteases

5 January 2020

cites work

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Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.

21 January 2018

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Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration.

21 January 2018

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Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

21 January 2018

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Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain

21 January 2018

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Presenilin attenuates receptor-mediated signaling and synaptic function.

21 January 2018

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The gamma-secretase complex: machinery for intramembrane proteolysis

21 January 2018

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

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Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin

21 January 2018

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Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

21 January 2018

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The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

21 January 2018

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The role of presenilin cofactors in the gamma-secretase complex

21 January 2018

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γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

21 January 2018

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Reconstitution of gamma-secretase activity

21 January 2018

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Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex

21 January 2018

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Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates

21 January 2018

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Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway

21 January 2018

1 reference

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Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane

21 January 2018

1 reference

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Monoubiquitination and endocytosis direct gamma-secretase cleavage of activated Notch receptor

21 January 2018

1 reference

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Phagocytosis of microbes: complexity in action

21 January 2018

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CD44 is a macrophage binding site for Mycobacterium tuberculosis that mediates macrophage recruitment and protective immunity against tuberculosis

21 January 2018

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C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells

21 January 2018

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Stable association of presenilin derivatives and absence of presenilin interactions with APP.

21 January 2018

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Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

21 January 2018

1 reference

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PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504069200

Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504069200

Biogenesis of phagolysosomes proceeds through a sequential series of interactions with the endocytic apparatus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504069200

Flotillin-1-enriched lipid raft domains accumulate on maturing phagosomes

21 January 2018

1 reference

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The phagosome proteome: insight into phagosome functions

21 January 2018

1 reference

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Organelle proteomics: looking at less to see more

21 January 2018

1 reference

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Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins

21 January 2018

1 reference

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The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced abeta 42 production mediated by familial early onset Alzheimer's disease-linked PS variants.

21 January 2018

1 reference

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Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli

21 January 2018

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ER-mediated phagocytosis: a new membrane for new functions

21 January 2018

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Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins

21 January 2018

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Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

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Membrane topology of gamma-secretase component PEN-2.

21 January 2018

1 reference

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Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes

21 January 2018

1 reference

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Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains

21 January 2018

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Interferon-γ: an overview of signals, mechanisms and functions

21 January 2018

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Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway

21 January 2018

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Differential glycosylation regulates processing of lipoprotein receptors by gamma-secretase

21 January 2018

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Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

21 January 2018

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Partial Purification and Characterization of γ-Secretase from Post-mortem Human Brain

21 January 2018

1 reference

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Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504069200

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504069200

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504069200

The presenilin proteins are components of multiple membrane-bound complexes that have different biological activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504069200

Focal exocytosis of VAMP3-containing vesicles at sites of phagosome formation

21 January 2018

1 reference

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Lysosome recruitment and fusion are early events required for trypanosome invasion of mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504069200

Endoplasmic reticulum-mediated phagocytosis is a mechanism of entry into macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504069200

Phagosomes are competent organelles for antigen cross-presentation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504069200

By Binding SIRPα or Calreticulin/CD91, Lung Collectins Act as Dual Function Surveillance Molecules to Suppress or Enhance Inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504069200

Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504069200

21 January 2018

Identifiers

DOI

10.1074/JBC.M504069200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16103123%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

1 reference