(Q40444024)

20 September 2017

title

Effects of RNAi-mediated silencing of PEN-2, APH-1a, and nicastrin on wild-type vs FAD mutant forms of presenilin 1. (English)

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20 September 2017

3

Rudolph E Tanzi

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20 September 2017

Zhongcong Xie

1

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20 September 2017

Donna M Romano

series ordinal

2

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20 September 2017

publication date

1 January 2005

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Journal of Molecular Neuroscience

20 September 2017

published in

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20 September 2017

volume

25

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20 September 2017

issue

1

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20 September 2017

page(s)

67-77

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https://scigraph.springernature.com/pub.10.1385/jmn:25:1:067

20 September 2017

exact match

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cites work

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

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12 December 2020

Protein topology of presenilin 1

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12 December 2020

Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

1 reference

12 December 2020

Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin

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12 December 2020

Reconstitution of gamma-secretase activity

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12 December 2020

A mutation in Alzheimer's disease destroying a splice acceptor site in the presenilin-1 gene.

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12 December 2020

Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease

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12 December 2020

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

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12 December 2020

Hypocapnia induces caspase-3 activation and increases Abeta production

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12 December 2020

Gamma-secretase activity is associated with a conformational change of nicastrin

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12 December 2020

The role of presenilin cofactors in the gamma-secretase complex

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12 December 2020

APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes

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12 December 2020

Endoproteolytic processing and stabilization of wild-type and mutant presenilin

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12 December 2020

Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex

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12 December 2020

Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin

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12 December 2020

Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex

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12 December 2020

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

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12 December 2020

The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex

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12 December 2020

Staurosporine-induced activation of caspase-3 is potentiated by presenilin 1 familial Alzheimer's disease mutations in human neuroglioma cells.

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12 December 2020

Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates

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12 December 2020

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

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12 December 2020

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

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12 December 2020

The role of presenilins in Alzheimer's disease

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12 December 2020

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

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12 December 2020

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

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12 December 2020

Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).

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12 December 2020

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

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12 December 2020

Membrane topology of the C. elegans SEL-12 presenilin

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12 December 2020

New frontiers in Alzheimer's disease genetics

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12 December 2020

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

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12 December 2020

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

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12 December 2020

Identifiers

DOI

10.1385/JMN:25:1:067

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Dimensions Publication ID

20 September 2017

1036245337

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