(Q46890595)

English

Calpain-regulated p35/cdk5 plays a central role in dopaminergic neuron death through modulation of the transcription factor myocyte enhancer factor 2.

scientific article published in January 2006

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scholarly article

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Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/16407541

Calpain-regulated p35/cdk5 plays a central role in dopaminergic neuron death through modulation of the transcription factor myocyte enhancer factor 2 (English)

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Europe PubMed Central

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11 May 2020

1 reference

based on heuristic

inferred from title

dopaminergic neuron

1 reference

based on heuristic

inferred from title

Patrice D. Smith

1

1 reference

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11 May 2020

10

1 reference

Europe PubMed Central

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11 May 2020

author name string

Matthew P Mount

2

1 reference

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11 May 2020

Raj Shree

3

1 reference

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11 May 2020

Steve Callaghan

4

1 reference

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11 May 2020

Ruth S Slack

5

1 reference

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11 May 2020

Hymie Anisman

6

1 reference

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11 May 2020

Inez Vincent

7

1 reference

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11 May 2020

Xuemin Wang

8

1 reference

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11 May 2020

Zixu Mao

9

1 reference

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11 May 2020

language of work or name

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publication date

1 January 2006

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/16407541

Journal of Neuroscience

1 reference

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11 May 2020

26

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11 May 2020

440-447

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11 May 2020

2

1 reference

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11 May 2020

Caspase and calpain substrates: roles in synaptic plasticity and cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of cyclin-dependent kinase 5 catalytic activity by phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcineurin enhances MEF2 DNA binding activity in calcium-dependent survival of cerebellar granule neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calpain-dependent proteolytic cleavage of the p35 cyclin-dependent kinase 5 activator to p25

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cdk5/p25(nck5a) interaction with synaptic proteins in bovine brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotoxicity induces cleavage of p35 to p25 by calpain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Central monoamine and plasma corticosterone changes induced by a bacterial endotoxin: sensitization and cross-sensitization effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myocyte enhancer factor 2A and 2D undergo phosphorylation and caspase-mediated degradation during apoptosis of rat cerebellar granule neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

c-Jun mediates axotomy-induced dopamine neuron death in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclin-dependent kinase 5 prevents neuronal apoptosis by negative regulation of c-Jun N-terminal kinase 3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of DARPP-32 dephosphorylation at PKA- and Cdk5-sites by NMDA and AMPA receptors: distinct roles of calcineurin and protein phosphatase-2A

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deregulation of cdk5, hyperphosphorylation, and cytoskeletal pathology in the Niemann-Pick type C murine model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cdk5-Mediated Inhibition of the Protective Effects of Transcription Factor MEF2 in Neurotoxicity-Induced Apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calpains mediate p53 activation and neuronal death evoked by DNA damage.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of calpains prevents neuronal and behavioral deficits in an MPTP mouse model of Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calpain and its involvement in the pathophysiology of CNS injuries and diseases: therapeutic potential of calpain inhibitors for prevention of neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The calpain system

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parkinson's disease: mechanisms and models

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cdk7 functions as a cdk5 activating kinase in brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased cyclin-dependent kinase 5 (cdk5) activity is accompanied by redistribution of cdk5 and cytoskeletal proteins and increased cytoskeletal protein phosphorylation in p35 null mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The regulation of cyclin-dependent kinase 5 activity through the metabolism of p35 or p39 Cdk5 activator

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclin-dependent kinase 5 regulates dopaminergic and glutamatergic transmission in the striatum

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of dopaminergic loss by Fas in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclin-dependent kinase-5 in neurodegeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CDKs: taking on a role as mediators of dopaminergic loss in Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclin-dependent kinase 5 phosphorylates serine 31 of tyrosine hydroxylase and regulates its stability

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclin-dependent kinase 5 mediates neurotoxin-induced degradation of the transcription factor myocyte enhancer factor 2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The calpain-calpastatin system in mammalian cells: properties and possible functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential roles of nuclear and cytoplasmic cyclin-dependent kinase 5 in apoptotic and excitotoxic neuronal death

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estimation of nuclear population from microtome sections

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Domain structure of calpain: mapping the binding site for calpastatin

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclins and their associated cyclin-dependent kinases in the human cell cycle

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased M-calpain expression in the mesencephalon of patients with Parkinson's disease but not in other neurodegenerative disorders involving the mesencephalon: a role in nerve cell death?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dopamine neurons from transgenic mice with a knockout of the p53 gene resist MPTP neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p35nck5a and cyclin-dependent kinase 5 colocalize in Lewy bodies of brains with Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calpain: a protease in search of a function?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurofilaments in health and disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16407541

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.2875-05.2006

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674390&resulttype=core&format=json

11 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674390&resulttype=core&format=json

11 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674390&resulttype=core&format=json

11 May 2020

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