(Q46610675)

English

Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice.

scientific article published in July 2005

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16033885%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16033885%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

Carlos A. Saura

1

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31 December 2019

Gunnar K. Gouras

7

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31 December 2019

Richard G. Morris

9

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31 December 2019

4

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31 December 2019

Alfredo Kirkwood

8

object named as

Alfredo Kirkwood

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31 December 2019

author name string

Guiquan Chen

2

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31 December 2019

Seema Malkani

3

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31 December 2019

Reisuke H Takahashi

5

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31 December 2019

Dawei Zhang

6

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31 December 2019

Jie Shen

10

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31 December 2019

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publication date

1 July 2005

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31 December 2019

Journal of Neuroscience

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31 December 2019

25

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31 December 2019

29

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31 December 2019

6755-6764

1 reference

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31 December 2019

Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Temporal accrual of complement proteins in amyloid plaques in Down's syndrome with Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impairment of hippocampal long-term potentiation by Alzheimer amyloid beta-peptides

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin-1 regulates neuronal differentiation during neurogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dementia with prominent frontotemporal features associated with L113P presenilin 1 mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-related impairment of synaptic transmission but normal long-term potentiation in transgenic mice that overexpress the human APP695SWE mutant form of amyloid precursor protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin-dependent gamma-secretase activity modulates thymocyte development

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Memory impairment and cholinergic dysfunction by centrally administered Abeta and carboxyl-terminal fragment of Alzheimer's APP in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

APP processing and synaptic plasticity in presenilin-1 conditional knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specific spatial learning deficits become severe with age in beta -amyloid precursor protein transgenic mice that harbor diffuse beta -amyloid deposits but do not form plaques

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A presenilin 1 mutation associated with familial frontotemporal dementia inhibits gamma-secretase cleavage of APP and notch.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of hAPPswe impairs rewarded alternation and contextual fear conditioning in a transgenic mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nectin-1alpha, an immunoglobulin-like receptor involved in the formation of synapses, is a substrate for presenilin/gamma-secretase-like cleavage

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that synaptically released beta-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term potentiation is increased in the CA1 area of the hippocampus of APP(swe/ind) CRND8 mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Syndecan 3 intramembrane proteolysis is presenilin/gamma-secretase-dependent and modulates cytosolic signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel presenilin 1 mutation associated with Pick's disease but not beta-amyloid plaques

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myeloproliferative disease in mice with reduced presenilin gene dosage: effect of gamma-secretase blockage

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of presenilin-1 in cortical lamination and survival of Cajal-Retzius neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of Alzheimer beta A4 amyloid precursor protein at central and peripheral synaptic sites.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid-(1-40) increases long-term potentiation in rat hippocampus in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Skeletal and CNS defects in Presenilin-1-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secreted form of beta-amyloid precursor protein shifts the frequency dependency for induction of LTD, and enhances LTP in hippocampal slices.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The presenilins and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Block of LTP in rat hippocampus in vivo by beta-amyloid precursor protein fragments.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglial response to amyloid plaques in APPsw transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer amyloid protein precursor in the rat hippocampus: transport and processing through the perforant path

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of PS1 deficiency on membrane protein trafficking in neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16033885

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.1247-05.2005

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16033885%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16033885%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16033885%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

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