(Q78525357)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12435726%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

title

Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein (English)

1 reference

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15 December 2019

10

Paul Greengard

1 reference

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15 December 2019

author name string

Dongming Cai

1

1 reference

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15 December 2019

Jae Yoon Leem

2

1 reference

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15 December 2019

Jeffrey P Greenfield

3

1 reference

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15 December 2019

Pei Wang

4

1 reference

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15 December 2019

Benny S Kim

5

1 reference

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15 December 2019

Runsheng Wang

6

1 reference

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15 December 2019

Kryslaine O Lopes

7

1 reference

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15 December 2019

Seong-Hun Kim

8

1 reference

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15 December 2019

Hui Zheng

9

1 reference

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15 December 2019

Sangram S Sisodia

11

1 reference

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15 December 2019

Gopal Thinakaran

12

1 reference

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15 December 2019

Huaxi Xu

13

1 reference

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15 December 2019

language of work or name

English

0 references

publication date

14 November 2002

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12435726%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

15 December 2019

published in

1 reference

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15 December 2019

volume

278

1 reference

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15 December 2019

page(s)

3446-3454

1 reference

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15 December 2019

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12435726%20AND%20SRC:MED&resulttype=core&format=json

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

15 December 2019

cites work

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Presenilins are not required for A beta 42 production in the early secretory pathway.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Cellular and molecular basis of beta-amyloid precursor protein metabolism

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Transport of vesicular stomatitis virus G protein to the cell surface is signal mediated in polarized and nonpolarized cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Alzheimer's presenilin 1 is a putative membrane receptor for rab GDP dissociation inhibitor

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Multiple effects of aspartate mutant presenilin 1 on the processing and trafficking of amyloid precursor protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Alzheimer amyloid protein precursor in the rat hippocampus: transport and processing through the perforant path

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Morphologic and biochemical analysis of the intracellular trafficking of the Alzheimer beta/A4 amyloid precursor protein.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Beta-amyloid precursor protein cleavage by a membrane-bound protease

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

A cell biological perspective on Alzheimer's disease

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Expression of beta-amyloid precursor protein-CD3gamma chimeras to demonstrate the selective generation of amyloid beta(1-40) and amyloid beta(1-42) peptides within secretory and endocytic compartments

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Calcium and GTP: essential components in vesicular trafficking between the endoplasmic reticulum and Golgi apparatus

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Effects of PS1 deficiency on membrane protein trafficking in neurons.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Estrogen lowers Alzheimer beta-amyloid generation by stimulating trans-Golgi network vesicle biogenesis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Alzheimer's disease. A firm base for drug development.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Amyloid precursor protein is synthesized by retinal ganglion cells, rapidly transported to the optic nerve plasma membrane and nerve terminals, and metabolized.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Prohormone processing in the trans-Golgi network: endoproteolytic cleavage of prosomatostatin and formation of nascent secretory vesicles in permeabilized cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Function and dysfunction of the presenilins

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Presenilin is required for activity and nuclear access of Notch in Drosophila

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Presenilins interact with Rab11, a small GTPase involved in the regulation of vesicular transport

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Presenilin, Notch, and the genesis and treatment of Alzheimer's disease

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Lack of requirement for presenilin1 in Notch1 signaling.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

The use of permeabilized cells to investigate secretory granule biogenesis.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Identifiers

DOI

10.1074/JBC.M209065200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12435726%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

1 reference