(Q44483354)

3 December 2017

Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model (English)

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3 December 2017

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12

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3 December 2017

Jinhe Li

1

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3 December 2017

Gregory J Fici

2

1 reference

3 December 2017

Chai-An Mao

3

1 reference

3 December 2017

Richard L Myers

4

1 reference

3 December 2017

Rongqing Shuang

5

1 reference

3 December 2017

Gregory P Donoho

6

1 reference

3 December 2017

Adele M Pauley

7

1 reference

3 December 2017

Carol S Himes

8

1 reference

3 December 2017

Wenning Qin

9

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3 December 2017

Ismail Kola

10

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3 December 2017

Kalpana M Merchant

11

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3 December 2017

language of work or name

English

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publication date

18 June 2003

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Journal of Biological Chemistry

3 December 2017

5

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based on heuristic

inferred from page(s)

published in

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3 December 2017

278

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3 December 2017

35

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3 December 2017

33445-33449

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The cell biology of Alzheimer's disease: uncovering the secrets of secretases

3 December 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301288200

Abeta-generating enzymes: recent advances in beta- and gamma-secretase research

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301288200

gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301288200

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301288200

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301288200

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301288200

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301288200

BiP binding keeps ATF6 at bay.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301288200

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301288200

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301288200

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301288200

Nicastrin binds to membrane-tethered Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301288200

Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301288200

Drosophila nicastrin is essential for the intramembranous cleavage of notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301288200

Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301288200

APH-2/nicastrin functions in LIN-12/Notch signaling in the Caenorhabditis elegans somatic gonad.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301288200

The role of presenilin cofactors in the gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301288200

Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301288200

Mice lacking both presenilin genes exhibit early embryonic patterning defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301288200

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301288200

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301288200

Skeletal and CNS defects in Presenilin-1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301288200

Notch1 is essential for postimplantation development in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301288200

Expression of a Delta homologue in prospective neurons in the chick

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301288200

Quantification of sub-femtomole amounts of Alzheimer amyloid beta peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301288200

Processing of the pre-beta-amyloid protein by cathepsin D is enhanced by a familial Alzheimer's disease mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301288200

Identification and characterization of presenilin-independent Notch signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301288200

Lack of requirement for presenilin1 in Notch1 signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301288200

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301288200

Regulation of amyloid precursor protein processing by presenilin 1 (PS1) and PS2 in PS1 knockout cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301288200

A sensitive and quantitative assay for measuring cleavage of presenilin substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301288200

Nuclear access and action of notch in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301288200

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301288200

The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301288200

21 January 2018

Identifiers

DOI

10.1074/JBC.M301288200

1 reference

3 December 2017

1 reference