(Q37456323)

English

Short-term supplementation with acetyl-L-carnitine and lipoic acid alters plasma protein carbonyl levels but does not improve cognition in aged beagles

scientific article published on 06 September 2009

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Short-term supplementation with acetyl-L-carnitine and lipoic acid alters plasma protein carbonyl levels but does not improve cognition in aged beagles (English)

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

author name string

Lori-Ann Christie

1

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Wycliffe O Opii

2

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Elizabeth Head

3

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Joseph A Araujo

4

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Christina de Rivera

5

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Norton W Milgram

6

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Carl W Cotman

7

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

publication date

6 September 2009

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Experimental Gerontology

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

44

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

12

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

752-759

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

The effect of acetyl-L-carnitine and R-alpha-lipoic acid treatment in ApoE4 mouse as a model of human Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787885

23 August 2017

Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787885

23 August 2017

Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787885

23 August 2017

Neuronal mitochondrial amelioration by feeding acetyl-L-carnitine and lipoic acid to aged rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787885

23 August 2017

The effects and mechanisms of mitochondrial nutrient alpha-lipoic acid on improving age-associated mitochondrial and cognitive dysfunction: an overview

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787885

23 August 2017

The effect of social networks on the relation between Alzheimer's disease pathology and level of cognitive function in old people: a longitudinal cohort study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787885

23 August 2017

Comparison of the effects of L-carnitine and acetyl-L-carnitine on carnitine levels, ambulatory activity, and oxidative stress biomarkers in the brain of old rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787885

23 August 2017

Cardiovascular fitness, cortical plasticity, and aging

1 reference

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23 August 2017

Cognitive experience and its effect on age-dependent cognitive decline in beagle dogs

1 reference

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23 August 2017

Landmark discrimination learning in the dog: effects of age, an antioxidant fortified food, and cognitive strategy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787885

23 August 2017

Brain aging in the canine: a diet enriched in antioxidants reduces cognitive dysfunction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787885

23 August 2017

Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787885

23 August 2017

Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787885

23 August 2017

Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L- carnitine and/or R-alpha -lipoic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787885

23 August 2017

Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787885

23 August 2017

Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787885

23 August 2017

Comparative longevity of pet dogs and humans: implications for gerontology research

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787885

23 August 2017

https://pubmed.ncbi.nlm.nih.gov/19735717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidants, antioxidants, and the degenerative diseases of aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787885

23 August 2017

Carnitine function and requirements during the life cycle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787885

23 August 2017

Size and reversal learning in the beagle dog as a measure of executive function and inhibitory control in aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787885

14 September 2017

Alpha-lipoic acid as a new treatment option for Alzheimer's disease--a 48 months follow-up analysis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787885

26 June 2018

Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: relevance to Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787885

26 June 2018

Visual-discrimination learning ability and beta-amyloid accumulation in the dog.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787885

26 June 2018

Cognitive functions and aging in the dog: acquisition of nonspatial visual tasks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787885

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Canine pituitary-testicular function in relation to toxicity testing

1 reference

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26 June 2018

Acetyl-L-carnitine and alpha-lipoic acid supplementation of aged beagle dogs improves learning in two landmark discrimination tests.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787885

2 September 2018

Proteomics analyses of specific protein oxidation and protein expression in aged rat brain and its modulation by L-acetylcarnitine: insights into the mechanisms of action of this proposed therapeutic agent for CNS disorders associated with oxidative

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787885

2 September 2018

Visuospatial function in the beagle dog: an early marker of cognitive decline in a model of human aging and dementia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787885

2 September 2018

Chronic dietary alpha-lipoic acid reduces deficits in hippocampal memory of aged Tg2576 mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787885

2 September 2018

Cognitive disturbances in old dogs suffering from the canine counterpart of Alzheimer's disease

1 reference

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2 September 2018

A comparison of egocentric and allocentric age-dependent spatial learning in the beagle dog.

1 reference

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2 September 2018

Learning ability in aged beagle dogs is preserved by behavioral enrichment and dietary fortification: a two-year longitudinal study.

1 reference

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2 September 2018

Histochemical accumulation of oxidative damage products is associated with Alzheimer-like pathology in the canine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787885

2 September 2018

Prior experience, antioxidants, and mitochondrial cofactors improve cognitive function in aged beagles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787885

2 September 2018

Long-term treatment with antioxidants and a program of behavioral enrichment reduces age-dependent impairment in discrimination and reversal learning in beagle dogs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787885

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The role of free radicals in canine counterpart of senile dementia of the Alzheimer type

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Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer's disease

1 reference

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Dietary enrichment counteracts age-associated cognitive dysfunction in canines

1 reference

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2 September 2018

Oxidative damage increases with age in a canine model of human brain aging

1 reference

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Visuospatial impairments in aged canines (Canis familiaris): the role of cognitive-behavioral flexibility.

1 reference

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Immunohistochemical investigation of the brain of aged dogs. I. Detection of neurofibrillary tangles and of 4-hydroxynonenal protein, an oxidative damage product, in senile plaques

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A 1-year controlled trial of acetyl-l-carnitine in early-onset AD.

1 reference

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Mitochondrial decay in aging. Reversal through supplementation of acetyl-L-carnitine and N-tert-butyl-alpha-phenyl-nitrone

1 reference

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Spatial memory and NGF levels in aged rats: natural variability and effects of acetyl-L-carnitine treatment.

1 reference

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The potent free radical scavenger alpha-lipoic acid improves memory in aged mice: putative relationship to NMDA receptor deficits.

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Life span and cancer mortality in the beagle dog and humans

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Age-related changes in LTP and antioxidant defenses are reversed by an α-lipoic acid-enriched diet

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.EXGER.2009.08.012

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

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