(Q37461029)

20 August 2017

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title

Focal nature of neurological disorders necessitates isotype-selective histone deacetylase (HDAC) inhibitors (English)

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20 August 2017

Elizabeth A Thomas

1

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20 August 2017

publication date

28 April 2009

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20 August 2017

published in

Molecular Neurobiology

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20 August 2017

volume

40

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20 August 2017

issue

1

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20 August 2017

page(s)

33-45

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Clinical-pathologic correlation in Huntington's disease: a neuropsychological and computed tomography study

20 August 2017

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12 December 2020

Evidence of a breakdown of corticostriatal connections in Parkinson's disease.

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12 December 2020

Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease.

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12 December 2020

Additive neuroprotective effects of a histone deacetylase inhibitor and a catalytic antioxidant in a transgenic mouse model of amyotrophic lateral sclerosis

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12 December 2020

Sodium butyrate ameliorates phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy

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12 December 2020

Trichostatin A increases SMN expression and survival in a mouse model of spinal muscular atrophy

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12 December 2020

Distinct pharmacological properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group

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12 December 2020

Microarray studies of psychostimulant-induced changes in gene expression

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12 December 2020

The expression of a small fraction of cellular genes is changed in response to histone hyperacetylation.

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12 December 2020

Histone deacetylases: focus on the nervous system

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12 December 2020

CREB-binding protein controls response to cocaine by acetylating histones at the fosB promoter in the mouse striatum

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12 December 2020

Pharmacological inhibition of histone deacetylases by suberoylanilide hydroxamic acid specifically alters gene expression and reduces ischemic injury in the mouse brain

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12 December 2020

The Sir2 family of protein deacetylases

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12 December 2020

Striatal histone modifications in models of levodopa-induced dyskinesia

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12 December 2020

Animal models of polyglutamine diseases and therapeutic approaches

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12 December 2020

Identification of genes up-regulated by histone deacetylase inhibition with cDNA microarray and exploration of epigenetic alterations on hepatoma cells.

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12 December 2020

Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family

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12 December 2020

Cloning and characterization of a histone deacetylase, HDAC9

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12 December 2020

Clinical development of histone deacetylase inhibitors as anticancer agents

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12 December 2020

Molecular biology of amyotrophic lateral sclerosis: insights from genetics

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12 December 2020

HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin

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12 December 2020

In vitro analysis of huntingtin-mediated transcriptional repression reveals multiple transcription factor targets

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12 December 2020

HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model

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12 December 2020

Therapeutic application of histone deacetylase inhibitors for central nervous system disorders

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12 December 2020

Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders.

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12 December 2020

Drugs of abuse: anatomy, pharmacology and function of reward pathways

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12 December 2020

Chemotherapy for the brain: the antitumor antibiotic mithramycin prolongs survival in a mouse model of Huntington's disease

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12 December 2020

Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia.

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12 December 2020

The neurocircuitry of addiction: an overview

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12 December 2020

Glutamine repeats and neurodegeneration

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12 December 2020

Selective vulnerability of the hippocampus in brain ischemia

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12 December 2020

Neuronal loss in layers V and VI of cerebral cortex in Huntington's disease

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12 December 2020

Abnormal gene product identified in hereditary dentatorubral–pallidoluysian atrophy (DRPLA) brain

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12 December 2020

Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity.

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12 December 2020

Histone deacetylases--an important class of cellular regulators with a variety of functions

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12 December 2020

Neurodegeneration. A glutamine-rich trail leads to transcription factors

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12 December 2020

Neuroprotective effects of phenylbutyrate against MPTP neurotoxicity.

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12 December 2020

In vitro and ex vivo evaluation of second-generation histone deacetylase inhibitors for the treatment of spinal muscular atrophy

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12 December 2020

Unstable expansion of CAG repeat in hereditary dentatorubral-pallidoluysian atrophy (DRPLA)

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12 December 2020

Cognitive neuroscience and the study of memory

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12 December 2020

Developmental expression of histone deacetylase 11 in the murine brain

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12 December 2020

Disulphide-reduced superoxide dismutase-1 in CNS of transgenic amyotrophic lateral sclerosis models

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12 December 2020

ESET/SETDB1 gene expression and histone H3 (K9) trimethylation in Huntington's disease

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12 December 2020

Histone deacetylase inhibitors improve learning consolidation in young and in KA-induced-neurodegeneration and SAMP-8-mutant mice

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12 December 2020

HATs and HDACs in neurodegeneration: a tale of disconcerted acetylation homeostasis.

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12 December 2020

Place navigation impaired in rats with hippocampal lesions

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12 December 2020

Structure and expression of the gene responsible for the triplet repeat disorder, dentatorubral and pallidoluysian atrophy (DRPLA)

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12 December 2020

The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice

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12 December 2020

Genome-wide significance for a modifier of age at neurological onset in Huntington's disease at 6q23-24: the HD MAPS study

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12 December 2020

The language of covalent histone modifications

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12 December 2020

Critical appraisal of DNA microarrays in psychiatric genomics.

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12 December 2020

Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy

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12 December 2020

Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action.

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12 December 2020

Modulation of nucleosome dynamics in Huntington's disease

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12 December 2020

Polyglutamine neurodegenerative diseases and regulation of transcription: assembling the puzzle

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12 December 2020

Sodium butyrate ameliorates histone hypoacetylation and neurodegenerative phenotypes in a mouse model for DRPLA.

1 reference

12 December 2020

Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum

1 reference

12 December 2020

The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease

1 reference

12 December 2020

Epigenetics and airways disease

1 reference

12 December 2020

Histone deacetylase inhibitors as therapeutics for polyglutamine disorders

1 reference

12 December 2020

Histone acetylation and methylation: combinatorial players for transcriptional regulation.

1 reference

12 December 2020

The nucleus accumbens and reward: neurophysiological investigations in behaving animals.

1 reference

12 December 2020

Brain chromatin remodeling: a novel mechanism of alcoholism.

1 reference

12 December 2020

Differential expression of 12 histone deacetylase (HDAC) genes in astrocytomas and normal brain tissue: class II and IV are hypoexpressed in glioblastomas

1 reference

12 December 2020

An introduction to the changes in gene expression that occur after cerebral ischaemia

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12 December 2020

Microtubule deacetylases, SirT2 and HDAC6, in the nervous system

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12 December 2020

HDAC inhibitor increases histone H3 acetylation and reduces microglia inflammatory response following traumatic brain injury in rats

1 reference

12 December 2020

Huntington's disease and dentatorubral-pallidoluysian atrophy: proteins, pathogenesis and pathology

1 reference

12 December 2020

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

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12 December 2020

Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome

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12 December 2020

The benzamide MS-275 is a potent, long-lasting brain region-selective inhibitor of histone deacetylases.

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12 December 2020

The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress

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12 December 2020

Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice

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12 December 2020

Transcriptional alterations and chromatin remodeling in polyglutamine diseases.

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12 December 2020

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12 December 2020

Cerebellar atrophy in Huntington's disease

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12 December 2020

Molecular profiling of antipsychotic drug function: convergent mechanisms in the pathology and treatment of psychiatric disorders

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12 December 2020

Gene profile analysis of osteoblast genes differentially regulated by histone deacetylase inhibitors

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12 December 2020

Gene expression profiling of substantia nigra dopamine neurons: further insights into Parkinson's disease pathology

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12 December 2020

Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner

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12 December 2020

Anticancer activities of histone deacetylase inhibitors

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12 December 2020

Sodium phenylbutyrate prolongs survival and regulates expression of anti-apoptotic genes in transgenic amyotrophic lateral sclerosis mice

1 reference

12 December 2020

Isoform-selective histone deacetylase inhibitors

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12 December 2020

Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases

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12 December 2020

Histone acetyltransferases

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12 December 2020

Stroke genomics: approaches to identify, validate, and understand ischemic stroke gene expression

1 reference

12 December 2020

Histone deacetylase activity is retained in primary neurons expressing mutant huntingtin protein

1 reference

12 December 2020

Memory systems of the brain: a brief history and current perspective

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12 December 2020

Valproic acid reduces brain damage induced by transient focal cerebral ischemia in rats: potential roles of histone deacetylase inhibition and heat shock protein induction

1 reference

12 December 2020

Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease

1 reference

12 December 2020

Acetylation of histones and transcription-related factors

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12 December 2020

The basal ganglia: learning new tricks and loving it.

1 reference

12 December 2020

Histone deacetylase inhibitors: possible implications for neurodegenerative disorders

1 reference

12 December 2020

Histone deacetylase inhibitors decrease cocaine but not sucrose self-administration in rats

1 reference

12 December 2020

Unraveling the mechanisms involved in motor neuron degeneration in ALS

1 reference

12 December 2020

Hereditary dentatorubral-pallidoluysian atrophy: Clinical and pathologic variants in a family

1 reference

12 December 2020

Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice

1 reference

12 December 2020

Spinal muscular atrophy: a deficiency in a ubiquitous protein; a motor neuron-specific disease

1 reference

12 December 2020

Molecular pathogenesis of spinocerebellar ataxias.

1 reference

12 December 2020

The neurobiology of cognition in schizophrenia.

1 reference

12 December 2020

Predictors of neuropathological severity in 100 patients with Huntington's disease

1 reference

12 December 2020

Histone deacetylase inhibitors: molecular mechanisms of action

1 reference

12 December 2020

Friedreich's ataxia: autosomal recessive disease caused by an intronic GAA triplet repeat expansion

1 reference

12 December 2020

Reduced Purkinje cell density in Huntington's disease

1 reference

12 December 2020

Distribution of histone deacetylases 1-11 in the rat brain

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12 December 2020

Chromatin structure and epigenetics.

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12 December 2020

Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors

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12 December 2020

Identification and functional significance of genes regulated by structurally different histone deacetylase inhibitors

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12 December 2020

Update on the treatment and management of schizophrenia and bipolar disorder.

1 reference

12 December 2020

A neostriatal habit learning system in humans.

1 reference

12 December 2020

10.1007/S12035-009-8067-Y

Identifiers

DOI

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release_kkuw2choobh2baprknp2vyp5ca

20 August 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/kkuw2choobh2baprknp2vyp5ca

24 November 2022

mapped directly with Wikidata item

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