(Q37470385)

20 August 2017

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title

High hyperdiploid childhood acute lymphoblastic leukemia (English)

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20 August 2017

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1

Kajsa Paulsson

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20 August 2017

Bertil Johansson

2

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20 August 2017

1 August 2009

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Genes, Chromosomes and Cancer

20 August 2017

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20 August 2017

48

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20 August 2017

637-660

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20 August 2017

8

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Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders

20 August 2017

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Is genomic imprinting involved in the pathogenesis of hyperdiploid and haploid acute lymphoblastic leukemia of childhood?

21 January 2018

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Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamics

21 January 2018

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Folate deficiency induces aneuploidy in human lymphocytes in vitro-evidence using cytokinesis-blocked cells and probes specific for chromosomes 17 and 21.

21 January 2018

1 reference

Molecular signatures in childhood acute leukemia and their correlations to expression patterns in normal hematopoietic subpopulations.

21 January 2018

1 reference

7 January 2021

FLT3 mutations in childhood acute lymphoblastic leukemia

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7 January 2021

Incidence and relevance of secondary chromosome abnormalities in childhood TEL/AML1+ acute lymphoblastic leukemia: an interphase FISH analysis.

1 reference

7 January 2021

Near-tetraploidy in childhood B-cell precursor acute lymphoblastic leukemia is a highly specific feature of ETV6/RUNX1-positive leukemic cases.

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7 January 2021

Molecular cytogenetic characterization of TCF3 (E2A)/19p13.3 rearrangements in B-cell precursor acute lymphoblastic leukemia.

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7 January 2021

Interphase cytogenetic study of childhood acute lymphoblastic leukemia.

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7 January 2021

The investigation of karyotypic instability in the high-hyperdiploidy subgroup of acute lymphoblastic leukemia

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7 January 2021

Racial and ethnic differences in survival of children with acute lymphoblastic leukemia

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7 January 2021

Nonrandom duplication of the chromosome bearing a mutated Ha-ras-1 allele in mouse skin tumors

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7 January 2021

Automated four-color interphase fluorescence in situ hybridization approach for the simultaneous detection of specific aneuploidies of diagnostic and prognostic significance in high hyperdiploid acute lymphoblastic leukemia

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7 January 2021

Six-year follow-up of the clinical significance of karyotype in acute lymphoblastic leukemia

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7 January 2021

Prognostic significance of CD34 expression in childhood B-precursor acute lymphocytic leukemia: a Pediatric Oncology Group study

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7 January 2021

Surface antigen phenotype can predict TEL-AML1 rearrangement in childhood B-precursor ALL: a Pediatric Oncology Group study

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7 January 2021

FLT3 inhibition selectively kills childhood acute lymphoblastic leukemia cells with high levels of FLT3 expression

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7 January 2021

A Quantitative Assay for the Number of Murine Lymphoma Cells capable of Proliferation in vivo

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7 January 2021

Distinct patterns of hematopoietic stem cell involvement in acute lymphoblastic leukemia

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7 January 2021

Karyotypic abnormalities create discordance of germline genotype and cancer cell phenotypes

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7 January 2021

Cytogenetics and prognosis in childhood lymphoblastic leukaemia: results of MRC UKALL X. Medical Research Council Working Party in Childhood Leukaemia

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7 January 2021

Possible explanation of the high concoddance for acute leukaemia in monozygotic twins

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7 January 2021

Prognostic significance of karyotype in a twelve-year follow-up in childhood acute lymphoblastic leukemia

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7 January 2021

Tiling resolution array comparative genomic hybridization, expression and methylation analyses of dup(1q) in Burkitt lymphomas and pediatric high hyperdiploid acute lymphoblastic leukemias reveal clustered near-centromeric breakpoints and overexpres

1 reference

7 January 2021

Vitamin and mineral supplements in pregnancy and the risk of childhood acute lymphoblastic leukaemia: a case-control study

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7 January 2021

Reassessment of childhood B-lineage lymphoblastic leukemia karyotypes using spectral analysis

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7 January 2021

Cytogenetics and their prognostic value in childhood and adult acute lymphoblastic leukemia (ALL) excluding L3

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7 January 2021

Association between acquired uniparental disomy and homozygous gene mutation in acute myeloid leukemias

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7 January 2021

Genes contributing to minimal residual disease in childhood acute lymphoblastic leukemia: prognostic significance of CASP8AP2

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7 January 2021

The incidence peaks of the childhood acute leukemias reflect specific cytogenetic aberrations

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7 January 2021

Cytogenetic findings in a population-based series of 787 childhood acute lymphoblastic leukemias from the Nordic countries. The NOPHO Leukemia Cytogenetic Study Group

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7 January 2021

Prognostic impact of karyotypic findings in childhood acute lymphoblastic leukaemia: a Nordic series comparing two treatment periods. For the Nordic Society of Paediatric Haematology and Oncology (NOPHO) Leukaemia Cytogenetic Study Group

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7 January 2021

Cytogenetic patterns in ETV6/RUNX1-positive pediatric B-cell precursor acute lymphoblastic leukemia: A Nordic series of 245 cases and review of the literature

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7 January 2021

Outcome of ETV6/RUNX1-positive childhood acute lymphoblastic leukaemia in the NOPHO-ALL-1992 protocol: frequent late relapses but good overall survival

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7 January 2021

Cytogenetic features of acute lymphoblastic and myeloid leukemias in pediatric patients with Down syndrome: an iBFM-SG study

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7 January 2021

Folate metabolic gene polymorphisms and childhood acute lymphoblastic leukemia: a case-control study.

1 reference

7 January 2021

Expression of BCR-ABL, E2A-PBX1, and MLL-AF4 fusion transcripts in newly diagnosed children with acute lymphoblastic leukemia: a Children's Cancer Group initiative

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7 January 2021

Aetiology of acute leukaemia

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7 January 2021

In utero origins of childhood leukaemia

1 reference

7 January 2021

Infection, immune responses and the aetiology of childhood leukaemia

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7 January 2021

Prenatal origin of childhood acute lymphoblastic leukemia, association with birth weight and hyperdiploidy.

1 reference

7 January 2021

Comparative expressed sequence hybridization studies of high-hyperdiploid childhood acute lymphoblastic leukemia.

1 reference

7 January 2021

Comparative genomic hybridization as part of a new diagnostic strategy in childhood hyperdiploid acute lymphoblastic leukemia.

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7 January 2021

Three distinct subgroups of hypodiploidy in acute lymphoblastic leukaemia

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7 January 2021

Interphase molecular cytogenetic screening for chromosomal abnormalities of prognostic significance in childhood acute lymphoblastic leukaemia: a UK Cancer Cytogenetics Group Study.

1 reference

7 January 2021

Pattern of malignant disorders in individuals with Down's syndrome.

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7 January 2021

Chromosome Abnormalities and Prognosis in Childhood Acute Leukemia

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7 January 2021

Karyotypic and clinical findings in a consecutive series of children with acute lymphocytic leukemia

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7 January 2021

Prognostic impact of trisomies of chromosomes 10, 17, and 5 among children with acute lymphoblastic leukemia and high hyperdiploidy (> 50 chromosomes)

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7 January 2021

Secondary cytogenetic aberrations in childhood Philadelphia chromosome positive acute lymphoblastic leukemia are nonrandom and may be associated with outcome

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7 January 2021

Specific extra chromosomes occur in a modal number dependent pattern in pediatric acute lymphoblastic leukemia.

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7 January 2021

Detection of numerical chromosome abnormalities by FISH in childhood acute lymphoblastic leukemia

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7 January 2021

Cytogenetic study of 105 children with acute lymphoblastic leukemia

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7 January 2021

Birth weight as a risk factor for childhood leukemia: a meta-analysis of 18 epidemiologic studies.

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7 January 2021

Birth weight and risk for childhood leukemia in Denmark, Sweden, Norway, and Iceland.

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7 January 2021

Antigen expression patterns reflecting genotype of acute leukemias

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7 January 2021

Aberrant expression of KOR-SA3544 antigen in childhood acute lymphoblastic leukemia predicts TEL-AML1 negativity. The Pediatric Hematology Working Group in the Czech Republic.

1 reference

7 January 2021

Hypercalcemia in childhood acute lymphoblastic leukemia: frequent implication of parathyroid hormone-related peptide and E2A-HLF from translocation 17;19.

1 reference

7 January 2021

Loss of heterozygosity in childhood acute lymphoblastic leukemia detected by genome-wide microarray single nucleotide polymorphism analysis.

1 reference

7 January 2021

Mesenchymal cells regulate the response of acute lymphoblastic leukemia cells to asparaginase

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7 January 2021

Favorable prognosis associated with hyperdiploidy in children with acute lymphocytic leukemia correlates with extra chromosome 6. A Pediatric Oncology Group study

1 reference

7 January 2021

Chromosomal findings and their correlation to prognosis in acute lymphocytic leukemia

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7 January 2021

Increased sensitivity of minimal residual disease detection by interphase FISH in acute lymphoblastic leukemia with hyperdiploidy

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7 January 2021

Investigation of clonal involvement of myeloid cells in Philadelphia-positive and high hyperdiploid acute lymphoblastic leukemia

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7 January 2021

Molecular allelokaryotyping of pediatric acute lymphoblastic leukemias by high-resolution single nucleotide polymorphism oligonucleotide genomic microarray

1 reference

7 January 2021

Evidence for an infective cause of childhood leukaemia: comparison of a Scottish new town with nuclear reprocessing sites in Britain

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7 January 2021

Cytogenetic findings in childhood acute lymphoblastic leukemia

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7 January 2021

Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia

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7 January 2021

Simultaneous occurrence of mongolism and leukemia; report of a nationwide survey

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7 January 2021

High-resolution genomic profiling of childhood ALL reveals novel recurrent genetic lesions affecting pathways involved in lymphocyte differentiation and cell cycle progression.

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7 January 2021

Stroma-supported culture in childhood B-lineage acute lymphoblastic leukemia cells predicts treatment outcome

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7 January 2021

Cellular DNA content and chromosome count in acute childhood leukemia and their significance for chemotherapy and prognosis

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7 January 2021

Chromosome aberrations in acute leukemia in childhood: analysis of 1009 patients

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7 January 2021

Leukemia-associated changes identified by quantitative flow cytometry: I. CD10 expression

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7 January 2021

Near-haploid common acute lymphoblastic leukaemia of childhood with a second hyperdiploid line: a DNA ploidy and fluorescence in-situ hybridization study

1 reference

7 January 2021

PRENATAL ORIGIN OF CHILDHOOD LEUKEMIA. EVIDENCE FROM TWINS

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7 January 2021

Prenatal origin of hyperdiploid acute lymphoblastic leukemia in identical twins.

1 reference

7 January 2021

Identification of preleukemic precursors of hyperdiploid acute lymphoblastic leukemia in cord blood

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7 January 2021

Comparison of fluorescence in situ hybridization, cytogenetic analysis, and DNA index analysis to detect chromosomes 4 and 10 aneuploidy in pediatric acute lymphoblastic leukemia: a Pediatric Oncology Group study

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7 January 2021

Isochromosomes in acute lymphoblastic leukaemia: i(21q) is a significant finding

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7 January 2021

Prospective study of childhood acute lymphocytic leukemia: hematologic, immunologic, and cytogenetic correlations

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7 January 2021

Results of the Dana-Farber Cancer Institute ALL Consortium Protocol 95-01 for children with acute lymphoblastic leukemia

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7 January 2021

Probes for hidden hyperdiploidy in acute lymphoblastic leukaemia

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7 January 2021

Outcome heterogeneity in childhood high-hyperdiploid acute lymphoblastic leukemia

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7 January 2021

Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia

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7 January 2021

Identification of numerical and structural chromosome aberrations in 15 high hyperdiploid childhood acute lymphoblastic leukemias using spectral karyotyping

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7 January 2021

Spectral karyotyping and interphase FISH reveal abnormalities not detected by conventional G-banding. Implications for treatment stratification of childhood acute lymphoblastic leukaemia: detailed analysis of 70 cases

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7 January 2021

Bone marrow fibrosis in childhood acute lymphoblastic leukemia correlates to biological factors, treatment response and outcome

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7 January 2021

Flow cytometric DNA index, G-band karyotyping, and comparative genomic hybridization in detection of high hyperdiploidy in childhood acute lymphoblastic leukemia

1 reference

7 January 2021

Hyperdiploidy arising from near-haploidy in childhood acute lymphoblastic leukemia

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7 January 2021

Chromosomes and causation of human cancer and leukemia.XXIII. Near-haploidy in acute leukemia

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7 January 2021

Nondisjunction of chromosomes leading to hyperdiploid childhood B-cell precursor acute lymphoblastic leukemia is an early event during leukemogenesis.

1 reference

7 January 2021

Formation of trisomies and their parental origin in hyperdiploid childhood acute lymphoblastic leukemia

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7 January 2021

Evidence for a single-step mechanism in the origin of hyperdiploid childhood acute lymphoblastic leukemia.

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7 January 2021

Identification of cryptic aberrations and characterization of translocation breakpoints using array CGH in high hyperdiploid childhood acute lymphoblastic leukemia

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7 January 2021

Characterisation of genomic translocation breakpoints and identification of an alternativeTCF3/PBX1fusion transcript in t(1;19)(q23;p13)-positive acute lymphoblastic leukaemias

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7 January 2021

Microdeletions are a general feature of adult and adolescent acute lymphoblastic leukemia: Unexpected similarities with pediatric disease

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7 January 2021

Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia.

1 reference

7 January 2021

Methylation of tumour suppressor gene promoters in the presence and absence of transcriptional silencing in high hyperdiploid acute lymphoblastic leukaemia.

1 reference

7 January 2021

A Strategy to Detect Chromosomal Abnormalities in Children With Acute Lymphoblastic Leukemia

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7 January 2021

Racial differences in the survival of childhood B-precursor acute lymphoblastic leukemia: a Pediatric Oncology Group Study

1 reference

7 January 2021

Nonrandom chromosomal abnormalities in acute lymphoblastic leukemia of childhood.

1 reference

7 January 2021

Correlation of karyotype and immunophenotype in childhood acute lymphoblastic leukemia

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7 January 2021

Results of Therapy for Acute Lymphoblastic Leukemia in Black and White Children

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7 January 2021

Novel potential ALL low-risk markers revealed by gene expression profiling with new high-throughput SSH-CCS-PCR.

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7 January 2021

Cytogenetically aberrant cells are present in the CD34+CD33-38-19- marrow compartment in children with acute lymphoblastic leukemia

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7 January 2021

Near-triploidy and near-tetraploidy in childhood acute lymphoblastic leukemia: association with B-lineage blast cells carrying the ETV6-RUNX1 fusion, T-lineage immunophenotype, and favorable outcome.

1 reference

7 January 2021

Detection of hyperdiploid karyotypes (>50 chromosomes) in childhood acute lymphoblastic leukemia (ALL) using fluorescence in situ hybridization (FISH)

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7 January 2021

5' CpG island hypermethylation is associated with transcriptional silencing of the p21(CIP1/WAF1/SDI1) gene and confers poor prognosis in acute lymphoblastic leukemia

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7 January 2021

Transcriptional silencing of the Dickkopfs-3 (Dkk-3) gene by CpG hypermethylation in acute lymphoblastic leukaemia

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7 January 2021

WNT5A, a putative tumour suppressor of lymphoid malignancies, is inactivated by aberrant methylation in acute lymphoblastic leukaemia

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7 January 2021

Classification of pediatric acute lymphoblastic leukemia by gene expression profiling

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7 January 2021

Impact of chromosomal translocations on prognosis in childhood acute lymphoblastic leukemia

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7 January 2021

Genetic studies of childhood acute lymphoblastic leukemia with emphasis on p16, MLL, and ETV6 gene abnormalities: results of St Jude Total Therapy Study XII

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7 January 2021

FISH mapping of i(7q) in acute leukemias and myxoid liposarcoma reveals clustered breakpoints in 7p11.2: implications for formation and pathogenetic outcome of the idic(7)(p11.2)

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7 January 2021

Is the risk of acute lymphoblastic leukemia reduced in siblings to children with the disease? A novel hypothesis explored by international collaboration

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7 January 2021

Risk- and response-based classification of childhood B-precursor acute lymphoblastic leukemia: a combined analysis of prognostic markers from the Pediatric Oncology Group (POG) and Children's Cancer Group (CCG).

1 reference

7 January 2021

Prognostic implications of chromosomal findings in acute lymphoblastic leukaemia at diagnosis

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7 January 2021

Bone marrow chromosomes in acute lymphoblastic leukaemia: A long-term study

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7 January 2021

Chromosomes and other prognostic factors in acute lymphoblastic leukaemia: a long-term follow-up

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7 January 2021

Children with hyperdiploid but not triple trisomy (+4,+10,+17) acute lymphoblastic leukemia have an increased incidence of extramedullary relapse on current therapies: a single institution experience

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7 January 2021

Phenotypic and karyotypic properties of hyperdiploid acute lymphoblastic leukaemia of childhood

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7 January 2021

DNA index and %S-phase cells determined in acute lymphoblastic leukemia of children: a report from studies ALL V, ALL VI, and ALL VII (1979-1991) of the Dutch Childhood Leukemia Study Group and The Netherlands Workgroup on Cancer Genetics and Cytoge

1 reference

7 January 2021

D-HPLC analysis of the entire FLT3 gene in MLL rearranged and hyperdiploid acute lymphoblastic leukemia.

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7 January 2021

Near haploid childhood acute lymphoblastic leukemia masked by hyperdiploid line: detection by fluorescence in situ hybridization

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7 January 2021

Genome complexity in acute lymphoblastic leukemia is revealed by array-based comparative genomic hybridization

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7 January 2021

A comprehensive analysis of the CDKN2A gene in childhood acute lymphoblastic leukemia reveals genomic deletion, copy number neutral loss of heterozygosity, and association with specific cytogenetic subgroups.

1 reference

7 January 2021

High concordance from independent studies by the Children's Cancer Group (CCG) and Pediatric Oncology Group (POG) associating favorable prognosis with combined trisomies 4, 10 and 17 in children with NCI Standard-Risk B-precursor Acute Lymphoblastic

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7 January 2021

Blast cell methotrexate-polyglutamate accumulation in vivo differs by lineage, ploidy, and methotrexate dose in acute lymphoblastic leukemia

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7 January 2021

FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy

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7 January 2021

Genetic evidence for lineage-related and differentiation stage-related contribution of somatic PTPN11 mutations to leukemogenesis in childhood acute leukemia

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7 January 2021

High frequency of leukemic clones in newborn screening blood samples of children with B-precursor acute lymphoblastic leukemia

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7 January 2021

Genetic susceptibility to childhood common acute lymphoblastic leukaemia is associated with polymorphic peptide-binding pocket profiles in HLA-DPB1*0201

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7 January 2021

Chromosomal abnormalities in acute lymphoblastic leukemia: structural and numerical changes in 234 cases

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7 January 2021

Clinical significance of chromosomal abnormalities in acute lymphoblastic leukemia

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7 January 2021

Maternal folate supplementation in pregnancy and protection against acute lymphoblastic leukaemia in childhood: a case-control study

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7 January 2021

Absence of G-CSF receptors and absent response to G-CSF in childhood Burkitt's lymphoma and B-ALL cells.

1 reference

7 January 2021

Heterogeneity of t(1;19)(q23;p13) acute leukaemias. French Haematological Cytology Group

1 reference

7 January 2021

The United Kingdom Childhood Cancer Study: objectives, materials and methods. UK Childhood Cancer Study Investigators

1 reference

7 January 2021

Prospective gene expression analysis accurately subtypes acute leukaemia in children and establishes a commonality between hyperdiploidy and t(12;21) in acute lymphoblastic leukaemia

1 reference

7 January 2021

Accumulation of methotrexate polyglutamates, ploidy and trisomies of both chromosomes 4 and 10 in lymphoblasts from children with B-progenitor cell acute lymphoblastic leukemia: a Pediatric Oncology Group Study

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7 January 2021

Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia

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7 January 2021

RAS mutation is associated with hyperdiploidy and parental characteristics in pediatric acute lymphoblastic leukemia

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7 January 2021

No evidence for preferential maternal origin of duplicated chromosome 14 in hyperdiploid ALL

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7 January 2021

Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling

1 reference

7 January 2021

Increased incidence of spontaneous apoptosis in the bone marrow of hyperdiploid childhood acute lymphoblastic leukemia

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7 January 2021

Hypermethylation of the 5' CpG island of the FHIT gene is associated with hyperdiploid and translocation-negative subtypes of pediatric leukemia

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7 January 2021

Trisomy 7-harbouring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomas

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7 January 2021

Identifiers

DOI

10.1002/GCC.20671

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20 August 2017

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PubMed ID

19415723