(Q37540897)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27820802%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

title

Inhibition of RAS function through targeting an allosteric regulatory site (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27820802%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27820802%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

Matthew J. Smith

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27820802%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

Mitsuhiko Ikura

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27820802%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

John P O'Bryan

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27820802%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

author name string

Russell Spencer-Smith

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27820802%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

Akiko Koide

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27820802%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

Yong Zhou

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27820802%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

Fern Sha

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27820802%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

Priyanka Gajwani

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27820802%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

Dianicha Santana

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27820802%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

Ankit Gupta

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27820802%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

Miranda Jacobs

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27820802%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

Erika Herrero-Garcia

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27820802%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

Jacqueline Cobbert

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27820802%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

Hugo Lavoie

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27820802%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

Thanashan Rajakulendran

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27820802%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

Evan Dowdell

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27820802%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

Mustafa Nazir Okur

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27820802%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

Irina Dementieva

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27820802%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

Frank Sicheri

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27820802%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

Marc Therrien

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27820802%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

John F Hancock

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27820802%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

Shohei Koide

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27820802%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

Matthew Smith

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27820802%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

publication date

7 November 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27820802%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

published in

Nature Chemical Biology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27820802%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

volume

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27820802%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27820802%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

page(s)

62-68

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27820802%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

26 March 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5193369/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/nchembio.2231

0 references

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23 August 2017

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Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange

23 August 2017

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Signal integration by lipid-mediated spatial cross talk between Ras nanoclusters

23 August 2017

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K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

23 August 2017

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Single-molecule superresolution imaging allows quantitative analysis of RAF multimer formation and signaling

23 August 2017

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Dissection of the BCR-ABL signaling network using highly specific monobody inhibitors to the SHP2 SH2 domains

23 August 2017

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Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization

23 August 2017

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In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction

23 August 2017

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Inhibition of Ras-Effector Interaction by Cyclic Peptides

23 August 2017

1 reference

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Effects of Raf dimerization and its inhibition on normal and disease-associated Raf signaling

23 August 2017

1 reference

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A new dimension to Ras function: a novel role for nucleotide-free Ras in Class II phosphatidylinositol 3-kinase beta (PI3KC2β) regulation

23 August 2017

1 reference

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Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5193369

Target-binding proteins based on the 10th human fibronectin type III domain (¹⁰Fn3).

23 August 2017

1 reference

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Teaching an Old Scaffold New Tricks: Monobodies Constructed Using Alternative Surfaces of the FN3 Scaffold

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5193369

An orthosteric inhibitor of the Ras-Sos interaction

23 August 2017

1 reference

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Ras history: The saga continues

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5193369

Isoform-specific monobody inhibitors of small ubiquitin-related modifiers engineered using structure-guided library design

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5193369

PHENIX: a comprehensive Python-based system for macromolecular structure solution

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5193369

MolProbity: all-atom structure validation for macromolecular crystallography

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5193369

A dimerization-dependent mechanism drives RAF catalytic activation

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5193369

Phasercrystallographic software

23 August 2017

1 reference

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23 August 2017

1 reference

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Electrostatic interactions positively regulate K-Ras nanocluster formation and function

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5193369

A novel switch region regulates H-ras membrane orientation and signal output

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5193369

Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface

23 August 2017

1 reference

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23 August 2017

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23 August 2017

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H-ras, K-ras, and inner plasma membrane raft proteins operate in nanoclusters with differential dependence on the actin cytoskeleton

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5193369

Coot: model-building tools for molecular graphics

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5193369

Human RAS superfamily proteins and related GTPases

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5193369

Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5193369

Direct visualization of Ras proteins in spatially distinct cell surface microdomains

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5193369

The structural basis for the transition from Ras-GTP to Ras-GDP

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5193369

Vav2 is an activator of Cdc42, Rac1, and RhoA

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5193369

The fibronectin type III domain as a scaffold for novel binding proteins

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5193369

The structural basis of the activation of Ras by Sos

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5193369

The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5193369

Shape complementarity at protein/protein interfaces

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5193369

Rapid and efficient site-specific mutagenesis without phenotypic selection

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5193369

Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5193369

SIGNAL TRANSDUCTION. Membrane potential modulates plasma membrane phospholipid dynamics and K-Ras signaling.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5193369

The Ras G Domain Lacks the Intrinsic Propensity to Form Dimers

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5193369

Formation of the Ras dimer is essential for Raf-1 activation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5193369

Therapeutic targeting of oncogenic K-Ras by a covalent catalytic site inhibitor

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5193369

N-Ras forms dimers at POPC membranes

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5193369

Observing cell surface signaling domains using electron microscopy

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5193369

Oligomeric structure of p21 ras proteins as determined by radiation inactivation

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5193369

Ras signalling on the endoplasmic reticulum and the Golgi

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5193369

Nonradioactive determination of Ras-GTP levels using activated ras interaction assay

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5193369

A novel assay for the measurement of Raf-1 kinase activity

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5193369

Transient reversion of ras oncogene-induced cell transformation by antibodies specific for amino acid 12 of ras protein

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5193369

Constraint and turnover in sex-biased gene expression in the genus Drosophila

1 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2231

Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27820802

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

ProtorP: a protein-protein interaction analysis server

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27820802

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCHEMBIO.2231

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27820802%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27820802%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

1 reference