(Q27677868)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23630290%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

title

In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction (English)

1 reference

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29 February 2020

1 reference

14

1 reference

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29 February 2020

Takashi Kumasaka

20

1 reference

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29 February 2020

Masaki Yamamoto

21

1 reference

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29 February 2020

author name string

Fumi Shima

1

1 reference

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29 February 2020

Yoko Yoshikawa

2

1 reference

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29 February 2020

Min Ye

3

1 reference

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29 February 2020

Mitsugu Araki

4

1 reference

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29 February 2020

Shigeyuki Matsumoto

5

1 reference

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29 February 2020

Jingling Liao

6

1 reference

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29 February 2020

Lizhi Hu

7

1 reference

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29 February 2020

Takeshi Sugimoto

8

1 reference

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29 February 2020

Yuichi Ijiri

9

1 reference

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29 February 2020

Azusa Takeda

10

1 reference

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29 February 2020

Yuko Nishiyama

11

1 reference

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29 February 2020

Chie Sato

12

1 reference

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29 February 2020

Shin Muraoka

13

1 reference

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29 February 2020

Tsutomu Osoda

15

1 reference

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29 February 2020

Ken-ichiro Tsuda

16

1 reference

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29 February 2020

Tomoya Miyakawa

17

1 reference

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29 February 2020

Hiroaki Fukunishi

18

1 reference

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29 February 2020

Jiro Shimada

19

1 reference

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29 February 2020

Tohru Kataoka

22

1 reference

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29 February 2020

language of work or name

English

0 references

publication date

29 April 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23630290%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

29 February 2020

published in

1 reference

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29 February 2020

volume

110

1 reference

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29 February 2020

issue

20

1 reference

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29 February 2020

page(s)

8182-8187

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23630290%20AND%20SRC:MED&resulttype=core&format=json

Crystal structures of the state 1 conformations of the GTP-bound H-Ras protein and its oncogenic G12V and Q61L mutants

29 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657810

Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657810

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657810

Structural Basis for Conformational Dynamics of GTP-bound Ras Protein

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657810

Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657810

Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657810

Structural basis for the interaction of Ras with RalGDS

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657810

Regional polysterism in the GTP-bound form of the human c-Ha-Ras protein

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657810

The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657810

MOLMOL: a program for display and analysis of macromolecular structures

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657810

The guanine nucleotide-binding switch in three dimensions

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657810

Ras oncogenes: split personalities

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657810

Cancer. Addiction to oncogenes--the Achilles heal of cancer

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657810

Solution structure of the state 1 conformer of GTP-bound H-Ras protein and distinct dynamic properties between the state 1 and state 2 conformers

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657810

The Ras inhibitor farnesylthiosalicylic acid (Salirasib) disrupts the spatiotemporal localization of active Ras: a potential treatment for cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657810

Oncogene cooperation in tumor maintenance and tumor recurrence in mouse mammary tumors induced by Myc and mutant Kras

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657810

Tumour maintenance is mediated by eNOS.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657810

Discovery and development of sorafenib: a multikinase inhibitor for treating cancer.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657810

Crystal structure of M-Ras reveals a GTP-bound "off" state conformation of Ras family small GTPases.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657810

Essential role for oncogenic Ras in tumour maintenance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657810

Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro.

29 September 2017

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1217730110

Chemical Similarity Searching

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1217730110

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23630290

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1217730110

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23630290%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

ADS bibcode

2013PNAS..110.8182S

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23630290%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

PubMed publication ID

23630290

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23630290%20AND%20SRC:MED&resulttype=core&format=json