(Q34765346)

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The Ras inhibitor farnesylthiosalicylic acid (Salirasib) disrupts the spatiotemporal localization of active Ras: a potential treatment for cancer

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Europe PubMed Central

PubMed publication ID

4 August 2017

The Ras inhibitor farnesylthiosalicylic acid (Salirasib) disrupts the spatiotemporal localization of active Ras: a potential treatment for cancer (English)

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

1

object named as

Barak Rotblat

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

author name string

Marcello Ehrlich

2

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Roni Haklai

3

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Yoel Kloog

4

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

language of work or name

0 references

publication date

1 January 2008

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Methods in Enzymology

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Europe PubMed Central

PubMed publication ID

4 August 2017

439

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

467-489

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Spatiotemporal organization of Ras signaling: rasosomes and the galectin switch

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Nonconventional trafficking of Ras associated with Ras signal organization

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Use of retrovirus expression of interfering RNA to determine the contribution of activated K-Ras and ras effector expression to human tumor cell growth.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Distinct rates of palmitate turnover on membrane-bound cellular and oncogenic H-ras

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The Ras inhibitor farnesylthiosalicylic acid as a potential therapy for neurofibromatosis type 1.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Ras and Rho GTPases: a family reunion

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Linking oncogenic pathways with therapeutic opportunities

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Oncogenic pathway signatures in human cancers as a guide to targeted therapies

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Gene expression signature of human cancer cell lines treated with the ras inhibitor salirasib (S-farnesylthiosalicylic acid).

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Suppression of survivin expression in glioblastoma cells by the Ras inhibitor farnesylthiosalicylic acid promotes caspase-dependent apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

E2F1 identified by promoter and biochemical analysis as a central target of glioblastoma cell-cycle arrest in response to Ras inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

p21ras is modified by a farnesyl isoprenoid

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Essential role for oncogenic Ras in tumour maintenance

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Carboxyl methylation of Ras regulates membrane targeting and effector engagement

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Ras antagonist farnesylthiosalicylic acid (FTS) reduces glomerular cellular proliferation and macrophage number in rat thy-1 nephritis

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein prenylation: more than just glue?

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Ras family signaling: therapeutic targeting

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Palmitoylation and plasma membrane localization of Ras2p by a nonclassical trafficking pathway in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of receptor tyrosine kinases in G-protein-coupled receptor regulation of Ras: transactivation or parallel pathways?

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Targeting RAS signalling pathways in cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Growth inhibition of ras-dependent tumors in nude mice by a potent ras-dislodging antagonist

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Targeting of K-Ras 4B by S-trans,trans-farnesyl thiosalicylic acid

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Galectin-1 Augments Ras Activation and Diverts Ras Signals to Raf-1 at the Expense of Phosphoinositide 3-Kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Galectin-3 augments K-Ras activation and triggers a Ras signal that attenuates ERK but not phosphoinositide 3-kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Ras inhibition results in growth arrest and death of androgen-dependent and androgen-independent prostate cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Reversible intracellular translocation of KRas but not HRas in hippocampal neurons regulated by Ca2+/calmodulin.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The Ras antagonist S-farnesylthiosalicylic acid induces inhibition of MAPK activation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Ral-specific guanine nucleotide exchange factor activity opposes other Ras effectors in PC12 cells by inhibiting neurite outgrowth

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

A Ras inhibitor tilts the balance between Rac and Rho and blocks phosphatidylinositol 3-kinase-dependent glioblastoma cell migration

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure and dynamics of the full-length lipid-modified H-Ras protein in a 1,2-dimyristoylglycero-3-phosphocholine bilayer

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Creation of human tumour cells with defined genetic elements

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Orally administered FTS (salirasib) inhibits human pancreatic tumor growth in nude mice

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Dislodgment and accelerated degradation of Ras.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Ras inhibition leads to transcriptional activation of p53 and down-regulation of Mdm2: two mechanisms that cooperatively increase p53 function in colon cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Distinct requirements for Ras oncogenesis in human versus mouse cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Ras proteins: different signals from different locations

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Lipid rafts: contentious only from simplistic standpoints

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Ras plasma membrane signalling platforms

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Lipid rafts and membrane traffic

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Subcellular localization determines MAP kinase signal output.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Mitogen-activated protein kinase-dependent and protein kinase C-dependent pathways link the m1 muscarinic receptor to beta-amyloid precursor protein secretion

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Novel Ras antagonist blocks human melanoma growth

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Coordinated traffic of Grb2 and Ras during epidermal growth factor receptor endocytosis visualized in living cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Regioselectivity of alkylation of cyclomaltoheptaose (beta-cyclodextrin) and synthesis of its mono-2-O-methyl, -ethyl, -allyl, and -propyl derivatives.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

K-ras is an essential gene in the mouse with partial functional overlap with N-ras

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential modification of Ras proteins by ubiquitination

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The inhibition of human mesangial cell proliferation by S-trans, trans-farnesylthiosalicylic acid

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

RAS inhibitors: potential for cancer therapeutics

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

K-ras regulates the steady-state expression of matrix metalloproteinase 2 in fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

New insights into the mechanisms of protein palmitoylation.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Are prenyl groups on proteins sticky fingers or greasy handles?

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Farnesyl derivatives of rigid carboxylic acids-inhibitors of ras-dependent cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Selective inhibition of Ras-dependent cell growth by farnesylthiosalisylic acid

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifying optimal lipid raft characteristics required to promote nanoscale protein-protein interactions on the plasma membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Membrane interactions of a constitutively active GFP-Ki-Ras 4B and their role in signaling. Evidence from lateral mobility studies.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Activated K-Ras and H-Ras display different interactions with saturable nonraft sites at the surface of live cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Lipid rafts and plasma membrane microorganization: insights from Ras.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Galectin-1 binds oncogenic H-Ras to mediate Ras membrane anchorage and cell transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Compartmentalized signalling of Ras.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Geranylgeranyltransferase I as a target for anti-cancer drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

H-ras, K-ras, and inner plasma membrane raft proteins operate in nanoclusters with differential dependence on the actin cytoskeleton

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

GTP-dependent segregation of H-ras from lipid rafts is required for biological activity

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Direct visualization of Ras proteins in spatially distinct cell surface microdomains

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The Ras antagonist, farnesylthiosalicylic acid (FTS), inhibits experimentally-induced liver cirrhosis in rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

An acylation cycle regulates localization and activity of palmitoylated Ras isoforms

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Galectin-1(L11A) predicted from a computed galectin-1 farnesyl-binding pocket selectively inhibits Ras-GTP.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Three separable domains regulate GTP-dependent association of H-ras with the plasma membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Ras and its signals diffuse through the cell on randomly moving nanoparticles.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Individual palmitoyl residues serve distinct roles in H-ras trafficking, microlocalization, and signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Restoration of sensitivity to anoikis in Ras-transformed rat intestinal epithelial cells by a Ras inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Understanding Ras: 'it ain't over 'til it's over'.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The Ras inhibitor S-trans, trans-farnesylthiosalicylic acid exerts long-lasting neuroprotection in a mouse closed head injury model

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

K-ras4B and prenylated proteins lacking "second signals" associate dynamically with cellular membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Plasma membrane nanoswitches generate high-fidelity Ras signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The murine N-ras gene is not essential for growth and development

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Calmodulin binds to K-Ras, but not to H- or N-Ras, and modulates its downstream signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

A new functional Ras antagonist inhibits human pancreatic tumor growth in nude mice

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of phosphoinositide 3-kinase in activation of ras and mitogen-activated protein kinase by epidermal growth factor

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Disruption of cooperation between Ras and MycN in human neuroblastoma cells promotes growth arrest

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Suppression of lung cancer tumor growth in a nude mouse model by the Ras inhibitor salirasib (farnesylthiosalicylic acid).

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2900432-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0076-6879(07)00432-6

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

ResearchGate publication ID

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