(Q41915120)

14 October 2017

Therapeutic targeting of oncogenic K-Ras by a covalent catalytic site inhibitor (English)

1 reference

14 October 2017

Matthew Meyerson

13

0 references

John R. Engen

object named as

John R Engen

15

0 references

Pasi A Jänne

12

object named as

Pasi A Jänne

1 reference

14 October 2017

16

Nathanael S Gray

1 reference

14 October 2017

Sang Min Lim

1

1 reference

14 October 2017

Kenneth D Westover

2

1 reference

14 October 2017

Scott B Ficarro

3

1 reference

14 October 2017

Rane A Harrison

4

1 reference

14 October 2017

Hwan Geun Choi

5

1 reference

14 October 2017

Michael E Pacold

6

1 reference

14 October 2017

Martin Carrasco

7

1 reference

14 October 2017

John Hunter

8

1 reference

14 October 2017

Nam Doo Kim

9

1 reference

14 October 2017

Ting Xie

10

1 reference

14 October 2017

Taebo Sim

11

1 reference

14 October 2017

Jarrod A Marto

14

1 reference

14 October 2017

language of work or name

English

0 references

publication date

20 November 2013

1 reference

Angewandte Chemie International Edition

14 October 2017

0 references

volume

53

1 reference

14 October 2017

1

1 reference

14 October 2017

199-204

1 reference

Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling

14 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914205

Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914205

Ras inhibition via direct Ras binding--is there a path forward?

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914205

A comprehensive survey of Ras mutations in cancer

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914205

Discovery of Potent and Selective Covalent Inhibitors of JNK

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914205

The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914205

Therapeutic strategies for targeting ras proteins

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914205

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914205

A structure-guided approach to creating covalent FGFR inhibitors

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914205

Hydrogen exchange mass spectrometry: what is it and what can it tell us?

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914205

Novel mutant-selective EGFR kinase inhibitors against EGFR T790M

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914205

A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914205

Targeting cancer with small molecule kinase inhibitors

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914205

Functional interrogation of the kinome using nucleotide acyl phosphates

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914205

Increased frequency of the k-ras G12C mutation in MYH polyposis colorectal adenomas

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914205

Targeting RAS signalling pathways in cancer therapy

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914205

The guanine nucleotide-binding switch in three dimensions

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914205

The importance of being K-Ras

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914205

The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914205

Ras/Rap effector specificity determined by charge reversal

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914205

Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914205

Controlling cell chemistry with caged compounds

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914205

Mammalian Ras interacts directly with the serine/threonine kinase Raf

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914205

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914205

The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914205

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914205

ras oncogenes in human cancer: a review

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914205

Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914205

Prodrugs of phosphates and phosphonates

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914205

18 August 2018

Identifiers

DOI

10.1002/ANIE.201307387

1 reference

release_4dncpa6xbncblerad3t6ydx5ae

14 October 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/4dncpa6xbncblerad3t6ydx5ae

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

14 October 2017

1 reference