(Q37570243)

English

A novel bivalent HIV-1 entry inhibitor reveals fundamental differences in CCR5-μ-opioid receptor interactions between human astroglia and microglia

scientific article published on September 2013

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

A novel bivalent HIV-1 entry inhibitor reveals fundamental differences in CCR5-μ-opioid receptor interactions between human astroglia and microglia (English)

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

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1 reference

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inferred from title

Christopher K Arnatt

4

object named as

Christopher K Arnatt

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

1

object named as

Nazira El-Hage

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

author name string

Seth M Dever

2

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Elizabeth M Podhaizer

3

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Yan Zhang

5

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Europe PubMed Central

PMC publication ID

21 August 2017

Kurt F Hauser

6

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Europe PubMed Central

PMC publication ID

21 August 2017

language of work or name

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publication date

1 September 2013

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Europe PubMed Central

PMC publication ID

21 August 2017

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Europe PubMed Central

PMC publication ID

21 August 2017

27

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

14

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

2181-2190

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

A Bivalent Ligand Targeting the Putative Mu Opioid Receptor and Chemokine Receptor CCR5 Heterodimers: Binding Affinity versus Functional Activities

1 reference

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The immunologic effects of maraviroc intensification in treated HIV-infected individuals with incomplete CD4+ T-cell recovery: a randomized trial

1 reference

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23 August 2017

HIV and recent illicit drug use interact to affect verbal memory in women

1 reference

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23 August 2017

Opiate drug use and the pathophysiology of neuroAIDS.

1 reference

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23 August 2017

Differential expression and HIV-1 regulation of μ-opioid receptor splice variants across human central nervous system cell types

1 reference

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23 August 2017

Association of polymorphisms of the mu opioid receptor gene with the severity of HIV infection and response to HIV treatment

1 reference

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Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

1 reference

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Substance abuse increases the risk of neuropathy in an HIV-infected cohort

1 reference

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23 August 2017

Independent evolution of macrophage-tropism and increased charge between HIV-1 R5 envelopes present in brain and immune tissue.

1 reference

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23 August 2017

Design and synthesis of a bivalent ligand to explore the putative heterodimerization of the mu opioid receptor and the chemokine receptor CCR5.

1 reference

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23 August 2017

HIV-1 replication in the central nervous system occurs in two distinct cell types.

1 reference

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23 August 2017

HIV-1 coinfection and morphine coexposure severely dysregulate hepatitis C virus-induced hepatic proinflammatory cytokine release and free radical production: increased pathogenesis coincides with uncoordinated host defenses

1 reference

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23 August 2017

Neurocognitive impact of substance use in HIV infection

1 reference

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23 August 2017

Protein kinase Czeta mediates micro-opioid receptor-induced cross-desensitization of chemokine receptor CCR5.

1 reference

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23 August 2017

Drug treatment as HIV prevention: a research update

1 reference

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23 August 2017

Time to act: a call for comprehensive responses to HIV in people who use drugs

1 reference

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23 August 2017

Methadone maintenance therapy promotes initiation of antiretroviral therapy among injection drug users

1 reference

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23 August 2017

Human immunodeficiency virus-associated neurocognitive disorder: pathophysiology in relation to drug addiction

1 reference

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23 August 2017

Drug interactions between antiretroviral medications and medications used in the treatment of drug addiction: research needs

1 reference

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23 August 2017

Lack of clinically significant drug interactions between nevirapine and buprenorphine

1 reference

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23 August 2017

Integrated opioid use disorder and HIV treatment: rationale, clinical guidelines for addiction treatment, and review of interactions of antiretroviral agents and opioid agonist therapies

1 reference

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23 August 2017

A bivalent ligand (KMN-21) antagonist for mu/kappa heterodimeric opioid receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918492

23 August 2017

Morphine exacerbates HIV-1 Tat-induced cytokine production in astrocytes through convergent effects on [Ca(2+)](i), NF-kappaB trafficking and transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918492

23 August 2017

Bivalent ligands as specific pharmacological tools for G protein-coupled receptor dimers

1 reference

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23 August 2017

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

1 reference

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23 August 2017

Sustained-release naltrexone: novel treatment for opioid dependence

1 reference

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23 August 2017

Pharmacological Properties of Bivalent Ligands Containing Butorphan Linked to Nalbuphine, Naltrexone, and Naloxone at μ, δ, and κ Opioid Receptors

1 reference

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23 August 2017

Agonistic and antagonistic bivalent ligands for serotonin and dopamine receptors including their transporters

1 reference

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23 August 2017

Oral naltrexone as a treatment for relapse prevention in formerly opioid-dependent drug users: a systematic review and economic evaluation

1 reference

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23 August 2017

Pharmacokinetic drug interactions between opioid agonist therapy and antiretroviral medications: implications and management for clinical practice

1 reference

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23 August 2017

Peptide, peptidomimetic and small-molecule drug discovery targeting HIV-1 host-cell attachment and entry through gp120, gp41, CCR5 and CXCR4.

1 reference

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23 August 2017

Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series

1 reference

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23 August 2017

Diversity and complexity of the mu opioid receptor gene: alternative pre-mRNA splicing and promoters

1 reference

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23 August 2017

Molecular targets of opiate drug abuse in neuroAIDS.

1 reference

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23 August 2017

HIV-1 Tat and opiate-induced changes in astrocytes promote chemotaxis of microglia through the expression of MCP-1 and alternative chemokines

1 reference

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23 August 2017

Cells of the central nervous system as targets and reservoirs of the human immunodeficiency virus

1 reference

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Molecular structure and physiological functions of GABA(B) receptors

1 reference

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23 August 2017

Methylnaltrexone antagonizes opioid-mediated enhancement of HIV infection of human blood mononuclear phagocytes

1 reference

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23 August 2017

Morphine enhances HIV infection of human blood mononuclear phagocytes through modulation of beta-chemokines and CCR5 receptor

1 reference

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23 August 2017

Heterologous desensitization of opioid receptors by chemokines inhibits chemotaxis and enhances the perception of pain

1 reference

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23 August 2017

Methadone enhances human immunodeficiency virus infection of human immune cells

1 reference

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23 August 2017

Heterodimerization of G-protein-coupled receptors: pharmacology, signaling and trafficking

1 reference

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23 August 2017

Synergistic neurotoxicity of opioids and human immunodeficiency virus-1 Tat protein in striatal neurons in vitro

1 reference

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Role of heteromer formation in GABAB receptor function

1 reference

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23 August 2017

μ-opioid modulation of HIV-1 coreceptor expressionand HIV-1 replication

1 reference

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6 September 2017

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14 September 2017

A bivalent ligand (KDAN-18) containing delta-antagonist and kappa-agonist pharmacophores bridges delta2 and kappa1 opioid receptor phenotypes

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14 September 2017

A bivalent ligand (KDN-21) reveals spinal delta and kappa opioid receptors are organized as heterodimers that give rise to delta(1) and kappa(2) phenotypes. Selective targeting of delta-kappa heterodimers

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14 September 2017

Interactions of opioid and chemokine receptors: oligomerization of mu, kappa, and delta with CCR5 on immune cells

1 reference

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14 September 2017

Morphine regulates gene expression of alpha- and beta-chemokines and their receptors on astroglial cells via the opioid mu receptor

1 reference

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28 September 2017

Methadone induces CCR5 and promotes AIDS virus infection

1 reference

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28 September 2017

Morphine induces gene expression of CCR5 in human CEMx174 lymphocytes

1 reference

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28 September 2017

CNS effects of a CCR5 inhibitor in HIV-infected subjects: a pharmacokinetic and cerebral metabolite study

1 reference

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25 June 2018

CCL5/RANTES gene deletion attenuates opioid-induced increases in glial CCL2/MCP-1 immunoreactivity and activation in HIV-1 Tat-exposed mice

1 reference

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25 June 2018

Synergistic increases in intracellular Ca2+, and the release of MCP-1, RANTES, and IL-6 by astrocytes treated with opiates and HIV-1 Tat.

1 reference

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25 June 2018

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1 reference

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25 June 2018

Stereostructure-activity relationship of opioid agonist and antagonist bivalent ligands. Evidence for bridging between vicinal opioid receptors

1 reference

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25 June 2018

HIV-1 infection and nervous system abnormalities among a cohort of intravenous drug users

1 reference

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25 June 2018

Predisposition to accelerated Alzheimer-related changes in the brains of human immunodeficiency virus negative opiate abusers

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Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents

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1 September 2018

Design, synthesis and biological evaluation of a bivalent micro opiate and adenosine A1 receptor antagonist

1 reference

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1 September 2018

Absence of conditioned place preference or reinstatement with bivalent ligands containing mu-opioid receptor agonist and delta-opioid receptor antagonist pharmacophores

1 reference

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1 September 2018

Probing the membrane targeting C1 subdomains of PKC with bivalent ligands

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1 September 2018

CCR2 mediates increases in glial activation caused by exposure to HIV-1 Tat and opiates

1 reference

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1 September 2018

Characterization of a novel bivalent morphinan possessing kappa agonist and micro agonist/antagonist properties.

1 reference

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1 September 2018

Heterodimerization and cross-desensitization between the mu-opioid receptor and the chemokine CCR5 receptor

1 reference

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1 September 2018

Design and synthesis of novel dimeric morphinan ligands for kappa and micro opioid receptors

1 reference

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1 September 2018

Selective inactivation of CCR5 and decreased infectivity of R5 HIV-1 strains mediated by opioid-induced heterologous desensitization

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1 September 2018

Endomorphin-1 potentiates HIV-1 expression in human brain cell cultures: implication of an atypical mu-opioid receptor

1 reference

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1 September 2018

Astrocytes: HIV cellular reservoirs and important participants in neuropathogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918492

1 September 2018

Opiates as potential cofactors in progression of HIV-1 infections to AIDS.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918492

1 September 2018

Identifiers

10.1097/QAD.0B013E3283639804

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

ResearchGate publication ID

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