(Q37570577)

21 August 2017

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title

Targeting insulin sensitivity in the treatment of polycystic ovary syndrome (English)

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polycystic ovary syndrome

21 August 2017

main subject

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Renato Pasquali

1

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21 August 2017

Alessandra Gambineri

series ordinal

2

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21 August 2017

language of work or name

English

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publication date

1 October 2009

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Expert Opinion on Therapeutic Targets

21 August 2017

published in

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21 August 2017

volume

13

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21 August 2017

issue

10

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21 August 2017

page(s)

1205-1226

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Polycystic Ovary Syndrome

21 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Polycystic ovarian syndrome: pathophysiology, molecular aspects and clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Insulin resistance in polycystic ovary syndrome: progress and paradoxes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Lack of insulin resistance in fibroblasts from subjects with polycystic ovary syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Insulin resistance in the skeletal muscle of women with PCOS involves intrinsic and acquired defects in insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Insulin Augmentation of 17α-Hydroxylase Activity Is Mediated by Phosphatidyl Inositol 3-Kinase But Not Extracellular Signal-Regulated Kinase-1/2 in Human Ovarian Theca Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Aromatase activity in human granulosa cells during follicular development and the modulation by follicle-stimulating hormone and insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

The effects of insulin and insulin-like growth factors-I and -II on estradiol production by granulosa cells of polycystic ovaries.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Impaired insulin-dependent glucose metabolism in granulosa-lutein cells from anovulatory women with polycystic ovaries

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Metabolic syndrome: a solution in search of a problem

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Obesity and androgens: facts and perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Effect of testosterone on lipolysis in human pre-adipocytes from different fat depots

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Androgens and coronary artery disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Effect of testosterone on insulin stimulated IRS1 Ser phosphorylation in primary rat myotubes--a potential model for PCOS-related insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

The impact of obesity on reproduction in women with polycystic ovary syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Body composition characteristics and body fat distribution in lean women with polycystic ovary syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Impact of obesity on the risk for polycystic ovary syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

The polycystic ovary syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Polycystic ovary syndrome: a multifaceted disease from adolescence to adult age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Obesity and sex steroid changes across puberty: evidence for marked hyperandrogenemia in pre- and early pubertal obese girls

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Imprinting of female offspring with testosterone results in insulin resistance and changes in body fat distribution at adult age in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Postnatal testosterone exposure results in insulin resistance, enlarged mesenteric adipocytes, and an atherogenic lipid profile in adult female rats: comparisons with estradiol and dihydrotestosterone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Polycystic ovary syndrome and its developmental origins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Androgen excess in women: experience with over 1000 consecutive patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Preserved insulin sensitivity and {beta}-cell activity, but decreased glucose effectiveness in normal-weight women with the polycystic ovary syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Changes in glucose tolerance over time in women with polycystic ovary syndrome: a controlled study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Prevalence of type 2 diabetes mellitus and impaired glucose tolerance in Asian women with polycystic ovary syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Glucose intolerance in a large cohort of mediterranean women with polycystic ovary syndrome: phenotype and associated factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

The natural history of the metabolic syndrome in young women with the polycystic ovary syndrome and the effect of long-term oestrogen-progestagen treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Polycystic ovary syndrome and cardiovascular disease: a premature association?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Relationship to insulin resistance of the adult treatment panel III diagnostic criteria for identification of the metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: a comprehensive review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Consensus on infertility treatment related to polycystic ovary syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Metformin in the treatment of infertility in polycystic ovarian syndrome: an alternative perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

The polycystic ovary syndrome associated with morbid obesity may resolve after weight loss induced by bariatric surgery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Metformin revisited: re-evaluation of its properties and role in the pharmacopoeia of modern antidiabetic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Drug insight: insulin-sensitizing drugs in the treatment of polycystic ovary syndrome--a reappraisal

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Metformin inhibits mitochondrial permeability transition and cell death: a pharmacological in vitro study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Effect of metformin on fatty acid and glucose metabolism in freshly isolated hepatocytes and on specific gene expression in cultured hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Effects of metformin and rosiglitazone monotherapy on insulin-mediated hepatic glucose uptake and their relation to visceral fat in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Metformin prevents the development of acute lipid-induced insulin resistance in the rat through altered hepatic signaling mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Metformin Inhibits Hepatic Gluconeogenesis Through AMP-Activated Protein Kinase-Dependent Regulation of the Orphan Nuclear Receptor SHP

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Metformin enhances insulin signalling in insulin-dependent and-independent pathways in insulin resistant muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Differential effects of metformin and exercise on muscle adiposity and metabolic indices in human immunodeficiency virus-infected patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Metformin counters the insulin-induced suppression of fatty acid oxidation and stimulation of triacylglycerol storage in rodent skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Metformin and exercise reduce muscle FAT/CD36 and lipid accumulation and blunt the progression of high-fat diet-induced hyperglycemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Effects of troglitazone and metformin on glucose and lipid metabolism: alterations of two distinct molecular pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Regulation of glucose transport and insulin signaling by troglitazone or metformin in adipose tissue of type 2 diabetic subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Glucose uptake and perfusion in subcutaneous and visceral adipose tissue during insulin stimulation in nonobese and obese humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Metformin reduces lipolysis in primary rat adipocytes stimulated by tumor necrosis factor-alpha or isoproterenol

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Metformin inhibits intracellular lipid accumulation in the murine pre-adipocyte cell line, 3T3-L1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

The lipogenic enzymes DGAT1, FAS, and LPL in adipose tissue: effects of obesity, insulin resistance, and TZD treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

A comparison of the effects of thiazolidinediones and metformin on metabolic control in patients with type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Metformin for the treatment of the polycystic ovary syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Metformin directly inhibits androgen production in human thecal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Metformin-induced stimulation of adenosine 5' monophosphate-activated protein kinase (PRKA) impairs progesterone secretion in rat granulosa cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Insulin-sensitizing agents in polycystic ovary syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Metformin in polycystic ovary syndrome: systematic review and meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Insulin-sensitizing agents as primary therapy for patients with polycystic ovarian syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Is the addition of metformin efficacious in the treatment of clomiphene citrate-resistant patients with polycystic ovary syndrome? A structured literature review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Clomiphene citrate, metformin or both as first-step approach in treating anovulatory infertility in patients with polycystic ovary syndrome (PCOS): a systematic review of head-to-head randomized controlled studies and meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Insulin-Lowering Agents in the Management of Polycystic Ovary Syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Insulin sensitivity after metformin suspension in normal-weight women with polycystic ovary syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Metformin improves polycystic ovary syndrome symptoms irrespective of pre-treatment insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

The effects of rosiglitazone and metformin on insulin resistance and serum androgen levels in obese and lean patients with polycystic ovary syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Does adding metformin to clomifene citrate lead to higher pregnancy rates in a subset of women with polycystic ovary syndrome?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Clomiphene, Metformin, or Both for Infertility in the Polycystic Ovary Syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Ovulatory response to treatment of polycystic ovary syndrome is associated with a polymorphism in the STK11 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Novel single nucleotide polymorphisms of organic cation transporter 1 (SLC22A1) affecting transport functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Peroxisome proliferator-activated receptor gamma and metabolic disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Effect of rosiglitazone on glucose and non-esterified fatty acid metabolism in Type II diabetic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Effect of the insulin sensitizer pioglitazone on insulin resistance, hyperandrogenism, and ovulatory dysfunction in women with polycystic ovary syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Endocrine and metabolic effects of rosiglitazone in overweight women with PCOS: a randomized placebo-controlled study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Metabolic and hormonal changes induced by pioglitazone in polycystic ovary syndrome: a randomized, placebo-controlled clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Responses of serum androgen and insulin resistance to metformin and pioglitazone in obese, insulin-resistant women with polycystic ovary syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Effects of metformin and rosiglitazone, alone and in combination, in nonobese women with polycystic ovary syndrome and normal indices of insulin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Homocysteine levels in women with polycystic ovary syndrome treated with metformin versus rosiglitazone: a randomized study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Pioglitazone and metformin in obese women with polycystic ovary syndrome not optimally responsive to metformin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Acquired and inherited lipodystrophies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

A clinical approach to severe insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Premature atherosclerosis associated with monogenic insulin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

PPAR gamma and human metabolic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Monogenic polycystic ovary syndrome due to a mutation in the lamin A/C gene is sensitive to thiazolidinediones but not to metformin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Treatment with flutamide improves hyperinsulinemia in women with idiopathic hirsutism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Effect of flutamide and metformin administered alone or in combination in dieting obese women with polycystic ovary syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Treatment with flutamide, metformin, and their combination added to a hypocaloric diet in overweight-obese women with polycystic ovary syndrome: a randomized, 12-month, placebo-controlled study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Low-dose flutamide-metformin therapy for hyperinsulinemic hyperandrogenism in non-obese adolescents and women

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Low-dose flutamide for women with androgen excess: anti-androgenic efficacy and hepatic safety

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

The impact of metformin, oral contraceptives, and lifestyle modification on polycystic ovary syndrome in obese adolescent women in two randomized, placebo-controlled clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Obesity and the polycystic ovary syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

Fetal growth, length of gestation, and polycystic ovaries in adult life

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903190699

10.1517/14728220903190699

21 January 2018

Identifiers

DOI

1 reference

21 August 2017

1 reference