(Q37594760)

21 August 2017

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title

Pharmacology of morphine in obese patients: clinical implications (English)

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21 August 2017

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4

Arnaud Basdevant

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Jean-Michel Scherrmann

7

object named as

Jean Michel Scherrmann

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21 August 2017

5

Karine Clement

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21 August 2017

Célia Lloret Linares

1

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21 August 2017

Xavier Declèves

2

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21 August 2017

Jean Michel Oppert

3

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21 August 2017

Christophe Bardin

6

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21 August 2017

Jean Pierre Lepine

8

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21 August 2017

Jean François Bergmann

9

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21 August 2017

Stéphane Mouly

10

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21 August 2017

publication date

1 January 2009

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Clinical Pharmacokinetics

21 August 2017

published in

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21 August 2017

volume

48

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21 August 2017

issue

10

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21 August 2017

page(s)

635-651

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https://scigraph.springernature.com/pub.10.2165/11317150-000000000-00000

21 August 2017

exact match

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cites work

Predictive models for post-operative nausea and vomiting in patients using patient-controlled analgesia.

1 reference

https://api.crossref.org/works/10.2165%2F11317150-000000000-00000

Variation in postoperative analgesic requirements in the morbidly obese following gastric bypass surgery

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11317150-000000000-00000

Metabolic basis of drug interactions in the intensive care unit

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11317150-000000000-00000

The metabolism and bioavailability of morphine in patients with severe liver cirrhosis

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11317150-000000000-00000

The bioavailability and pharmacokinetics of morphine after intravenous, oral and buccal administration in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11317150-000000000-00000

Kinetics of intravenous and intramuscular morphine

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11317150-000000000-00000

The pharmacokinetics of morphine and morphine glucuronides in kidney failure

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11317150-000000000-00000

Total body water reference values and prediction equations for adults

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11317150-000000000-00000

Extrahepatic metabolism of morphine occurs in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11317150-000000000-00000

Expression and localization of the multidrug resistance-associated protein 3 in rat small and large intestine.

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11317150-000000000-00000

Efficacy of chemotherapeutic agents under hypoxic conditions in pulmonary adenocarcinoma multidrug resistant cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11317150-000000000-00000

Vancomycin pharmacokinetics in normal and morbidly obese subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11317150-000000000-00000

Increased intra-abdominal pressure and cardiac filling pressures in obesity-associated pseudotumor cerebri

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11317150-000000000-00000

Obesity and renal hemodynamics

21 January 2018

1 reference

12 December 2020

Pharmacokinetic modelling of morphine, morphine-3-glucuronide and morphine-6-glucuronide in plasma and cerebrospinal fluid of neurosurgical patients after short-term infusion of morphine

1 reference

12 December 2020

Significance of catechol-O-methyltransferase gene polymorphism in fibromyalgia syndrome

1 reference

12 December 2020

Effect of body weight on the pharmacokinetics of cyclophosphamide in breast cancer patients

1 reference

12 December 2020

Therapeutic drug monitoring of vancomycin in a morbidly obese patient

1 reference

12 December 2020

The frequency and timing of respiratory depression in 1524 postoperative patients treated with systemic or neuraxial morphine

1 reference

12 December 2020

Prevalence of overweight and obesity in the United States, 1999-2004

1 reference

12 December 2020

Pain sensitivity and obesity

1 reference

12 December 2020

Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors

1 reference

12 December 2020

The polymorphism A118G of the human mu-opioid receptor gene decreases the pupil constrictory effect of morphine-6-glucuronide but not that of morphine

1 reference

12 December 2020

Prediction of pharmacokinetic alterations caused by drug-drug interactions: metabolic interaction in the liver

1 reference

12 December 2020

Decreased expression and activity of P-glycoprotein in rat liver during acute inflammation.

1 reference

12 December 2020

Pharmacokinetic Modeling of M6G Formation after Oral Administration of Morphine in Healthy Volunteers

1 reference

12 December 2020

Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction

1 reference

12 December 2020

The influence of 5-HT(2C) and MDR1 genetic polymorphisms on antipsychotic-induced weight gain in female schizophrenic patients

1 reference

12 December 2020

Negative relationship between morphine analgesia and P-glycoprotein expression levels in the brain

1 reference

12 December 2020

Downregulation of mdr1a expression in the brain and liver during CNS inflammation alters the in vivo disposition of digoxin.

1 reference

12 December 2020

Lithium pharmacokinetics in the obese

1 reference

12 December 2020

Overview of enzymes of drug metabolism

1 reference

12 December 2020

Emergence and recovery characteristics of desflurane versus sevoflurane in morbidly obese adult surgical patients: a prospective, randomized study

1 reference

12 December 2020

Further observations on total body water. II. Changes of body composition in disease

1 reference

12 December 2020

Association of a polymorphism of ABCB1 with obesity in Japanese individuals.

1 reference

12 December 2020

Obesity and the metabolic syndrome: the stress on society

1 reference

12 December 2020

The Partial 5-Hydroxytryptamine1A Receptor Agonist Buspirone does not Antagonize Morphine-induced Respiratory Depression in Humans

1 reference

12 December 2020

Formation of highly analgesic morphine-6-glucuronide following physiologic concentration of morphine in human brain

1 reference

12 December 2020

Characteristics of the gastrointestinal absorption of morphine in rats

1 reference

12 December 2020

Pharmacokinetic Properties of Thiopental in Two Patients Treated for Uncontrollable Seizures

1 reference

12 December 2020

Pharmacokinetics and pharmacodynamics of vecuronium in the obese surgical patient

1 reference

12 December 2020

Melanocortin 4 receptor mutations in a large cohort of severely obese adults: prevalence, functional classification, genotype-phenotype relationship, and lack of association with binge eating

1 reference

12 December 2020

Catechol O-methyltransferase val158-met polymorphism is associated with abdominal obesity and blood pressure in men

1 reference

12 December 2020

Overexpression of multiple drug resistance genes in endothelial cells from patients with refractory epilepsy.

1 reference

12 December 2020

Effect of propranolol on morphine metabolism

1 reference

12 December 2020

Disposition of Morphine in Man

1 reference

12 December 2020

Influence of catechol-O-methyltransferase Val158Met polymorphism on neuropsychological and functional outcomes of classical rehabilitation and cognitive remediation in schizophrenia

1 reference

12 December 2020

Body composition measurements: interpretation finally made easy for clinical use.

1 reference

12 December 2020

Relative expansion of extracellular fluid in obese vs. nonobese women

1 reference

12 December 2020

Resolution of nonalcoholic steatohepatits after gastric bypass surgery

1 reference

12 December 2020

P-glycoprotein increases from proximal to distal regions of human small intestine

1 reference

12 December 2020

Regulation of the hepatic multidrug resistance gene expression by endotoxin and inflammatory cytokines in mice.

1 reference

12 December 2020

Pharmacokinetics of sufentanil in obese patients

1 reference

12 December 2020

Expression and immunolocalization of multidrug resistance protein 2 in rabbit small intestine.

1 reference

12 December 2020

Effect of obesity on cyclosporine trough concentrations in psoriasis patients

1 reference

12 December 2020

Enhancement of drug absorption by antacids. An unrecognised drug interaction

1 reference

12 December 2020

Acute-phase response, interleukin-6, and alteration of cyclosporine pharmacokinetics

1 reference

12 December 2020

Influence of ranitidine on the morphine-3-glucuronide to morphine-6-glucuronide ratio after oral administration of morphine in humans

1 reference

12 December 2020

Increased infiltration of macrophages in omental adipose tissue is associated with marked hepatic lesions in morbid human obesity.

1 reference

12 December 2020

Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats

1 reference

12 December 2020

COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor

1 reference

12 December 2020

1 reference

12 December 2020

Cytokines influence mRNA expression of cytochrome P450 3A4 and MDRI in intestinal cells

1 reference

12 December 2020

Effects of chronic renal failure on liver drug transporters

1 reference

12 December 2020

Obesity, sex, and acetaminophen disposition

1 reference

12 December 2020

1 reference

12 December 2020

Morphine-6-glucuronide might mediate the prolonged opioid effect of morphine in acute renal failure

1 reference

12 December 2020

Monitoring the obesity epidemic in France: the Obepi surveys 1997-2006.

1 reference

12 December 2020

Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects

1 reference

12 December 2020

The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene may influence morphine requirements in cancer pain patients

1 reference

12 December 2020

Genetic variation and response to morphine in cancer patients: catechol-O-methyltransferase and multidrug resistance-1 gene polymorphisms are associated with central side effects

1 reference

12 December 2020

Etiopathogenesis of nonalcoholic steatohepatitis

1 reference

12 December 2020

Genetic basis for individual variations in pain perception and the development of a chronic pain condition

1 reference

12 December 2020

Alterations in food intake by opioid and dopamine signaling pathways between the ventral tegmental area and the shell of the nucleus accumbens

1 reference

12 December 2020

Intravenous ciprofloxacin dosing in a morbidly obese patient

1 reference

12 December 2020

Effect of age, gender, and obesity on midazolam kinetics.

1 reference

12 December 2020

Drug glucuronidation in clinical psychopharmacology

1 reference

12 December 2020

No evidence for allelic association between schizophrenia and a polymorphism determining high or low catechol O-methyltransferase activity

1 reference

12 December 2020

Acute hepatic and renal toxicity from low doses of acetaminophen in the absence of alcohol abuse or malnutrition: evidence for increased susceptibility to drug toxicity due to cardiopulmonary and renal insufficiency

1 reference

12 December 2020

Expression and immunolocalization of the multidrug resistance proteins, MRP1-MRP6 (ABCC1-ABCC6), in human brain

1 reference

12 December 2020

Prolongation of ifosfamide elimination half-life in obese patients due to altered drug distribution

1 reference

12 December 2020

ABC of oral bioavailability: transporters as gatekeepers in the gut.

1 reference

12 December 2020

Physical and emotional stress have differential effects on preference for saccharine and open field behaviour in rats

1 reference

12 December 2020

Laparoscopic Roux-en-Y gastric bypass for severe gastroesophageal reflux after vertical banded gastroplasty

1 reference

12 December 2020

Morphine pharmacokinetics and metabolism in humans. Enterohepatic cycling and relative contribution of metabolites to active opioid concentrations

1 reference

12 December 2020

Propofol infusion for maintenance of anesthesia in morbidly obese patients receiving nitrous oxide. A clinical and pharmacokinetic study.

1 reference

12 December 2020

Association between the cortisol response to opioid blockade and the Asn40Asp polymorphism at the mu-opioid receptor locus (OPRM1).

1 reference

12 December 2020

Serum beta-endorphin levels in morbidly obese patients: the effect of vertical banded gastroplasty

1 reference

12 December 2020

Surface area of the small intestine in man

1 reference

12 December 2020

Increased expression of mu opioid receptors in animals susceptible to diet-induced obesity

1 reference

12 December 2020

Evaluation of body fat in fatter and leaner 10-y-old African American and white children: the Baton Rouge Children's Study

1 reference

12 December 2020

Genetic mutations that prevent pain: implications for future pain medication

1 reference

12 December 2020

Remifentanil pharmacokinetics in obese versus lean patients.

1 reference

12 December 2020

The mu-opioid receptor gene polymorphism (A118G) alters HPA axis activation induced by opioid receptor blockade

1 reference

12 December 2020

Medication and nutrient administration considerations after bariatric surgery

1 reference

12 December 2020

Drug disposition in obese humans. An update

1 reference

12 December 2020

Antibiotic prophylaxis for surgery in morbidly obese patients

1 reference

12 December 2020

Morphine kinetics in cancer patients

1 reference

12 December 2020

Glomerular volume and renal histology in obese and non-obese living kidney donors

1 reference

12 December 2020

The disposition of morphine and its 3- and 6-glucuronide metabolites in humans and animals, and the importance of the metabolites to the pharmacological effects of morphine.

1 reference

12 December 2020

Does the A118G polymorphism at the mu-opioid receptor gene protect against morphine-6-glucuronide toxicity?

1 reference

12 December 2020

Supraspinal brain-derived neurotrophic factor signaling: a novel mechanism for descending pain facilitation.

1 reference

12 December 2020

The effects of obesity on the pharmacokinetics and pharmacodynamics of glipizide in patients with non-insulin-dependent diabetes mellitus.

1 reference

12 December 2020

Critical respiratory events in the postanesthesia care unit. Patient, surgical, and anesthetic factors.

1 reference

12 December 2020

Gut Microbiota and Its Possible Relationship With Obesity

1 reference

12 December 2020

Health services use and health care costs of obese and nonobese individuals

1 reference

12 December 2020

Multidrug resistance proteins 2 and 3 provide alternative routes for hepatic excretion of morphine-glucuronides

1 reference

12 December 2020

Catechol-O-methyltransferase Vall58Met polymorphism: frequency analysis in Han Chinese subjects and allelic association of the low activity allele with bipolar affective disorder

1 reference

12 December 2020

Anesthesia in the obese patient: pharmacokinetic considerations

1 reference

12 December 2020

Relationship between pain and obesity: An electrophysiological study

1 reference

12 December 2020

Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT gene

1 reference

12 December 2020

A de novo mutation affecting human TrkB associated with severe obesity and developmental delay

1 reference

12 December 2020

OPRM1 gene is associated with BMI in Uyghur population

1 reference

12 December 2020

No association between anxiety disorders and catechol-O-methyltransferase polymorphism

1 reference

12 December 2020

Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss

1 reference

12 December 2020

Regional effect of naltrexone in the nucleus of the solitary tract in blockade of NPY-induced feeding

1 reference

12 December 2020

Functional and structural changes in the kidney in the early stages of obesity

1 reference

12 December 2020

The pharmacokinetics of daptomycin in moderately obese, morbidly obese, and matched nonobese subjects

1 reference

12 December 2020

Poor permeability of morphine 3-glucuronide and morphine 6-glucuronide through the blood-brain barrier in the rat

1 reference

12 December 2020

Evidence for an active transport of morphine-6-beta-d-glucuronide but not P-glycoprotein-mediated at the blood-brain barrier.

1 reference

12 December 2020

Influence of weight on aminoglycoside pharmacokinetics in normal weight and morbidly obese patients

1 reference

12 December 2020

Randomized placebo-controlled trial of the activity of the morphine glucuronides

1 reference

12 December 2020

Localisation of drug permeability along the rat small intestine, using markers of the paracellular, transcellular and some transporter routes

1 reference

12 December 2020

Adiposity signals, genetic and body weight regulation in humans

1 reference

12 December 2020

Pain thresholds in obese binge-eating disorder subjects

1 reference

12 December 2020

Pharmacodynamic Effect of Morphine-6-glucuronide versus Morphine on Hypoxic and Hypercapnic Breathing in Healthy Volunteers

1 reference

12 December 2020

Intake of high-fat food is selectively enhanced by mu opioid receptor stimulation within the nucleus accumbens.

1 reference

12 December 2020

The association of obesity with joint pain and osteoarthritis in the HANES data

1 reference

12 December 2020

Endogenous TrkB ligands suppress functional mechanosensory plasticity in the deafferented spinal cord

1 reference

12 December 2020

Drug Distribution in Obesity and following Bariatric Surgery: A Literature Review

1 reference

12 December 2020

Expression and localization of multidrug resistant protein mrp2 in rat small intestine.

1 reference

12 December 2020

The 118 A > G polymorphism in the human mu-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease

1 reference

12 December 2020

A comparison of intrathecal morphine-6-glucuronide and intrathecal morphine sulfate as analgesics for total hip replacement

1 reference

12 December 2020

Normal metabolism of morphine in cirrhosis

1 reference

12 December 2020

Persistently high plasma morphine-6-glucuronide levels despite decreased hourly patient-controlled analgesia morphine use after single-dose diclofenac: potential for opioid-related toxicity

1 reference

12 December 2020

Pharmacokinetic-pharmacodynamic modeling of morphine-6-glucuronide-induced analgesia in healthy volunteers: absence of sex differences

1 reference

12 December 2020

Tumor necrosis factor alpha and endothelin-1 increase P-glycoprotein expression and transport activity at the blood-brain barrier

1 reference

12 December 2020

On the mechanism of intestinal absorption of drugs

1 reference

12 December 2020

Ethnicity influences morphine pharmacokinetics and pharmacodynamics

1 reference

12 December 2020

Morphine-6-glucuronide: morphine's successor for postoperative pain relief?

1 reference

12 December 2020

Screening of multidrug-resistance sensitive drugs by in situ brain perfusion in P-glycoprotein-deficient mice

1 reference

12 December 2020

Total body water estimation using bioelectrical impedance: a meta-analysis of the data available in the literature.

1 reference

12 December 2020

Antagonism of the melanocortin system reduces cold and mechanical allodynia in mononeuropathic rats

1 reference

12 December 2020

Resistance to diet-induced obesity in mu-opioid receptor-deficient mice: evidence for a "thrifty gene".

1 reference

12 December 2020

Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme

1 reference

12 December 2020

Role of P-glycoprotein in the intestinal absorption and clinical effects of morphine

1 reference

12 December 2020

Genetic variability and clinical efficacy of morphine

1 reference

12 December 2020

Morphine-6-glucuronide: actions and mechanisms

1 reference

12 December 2020

Effects of the opiate antagonist, naltrexone, on binging antecedents and plasma beta-endorphin concentrations.

1 reference

12 December 2020

Naloxone, an opiate blocker, reduces the consumption of sweet high-fat foods in obese and lean female binge eaters

1 reference

12 December 2020

Drug absorption and hepatic drug metabolism in patients with different types of intestinal shunt operation for obesity. A study with phenazone

1 reference

12 December 2020

Intestinal inflammation induces adaptation of P-glycoprotein expression and activity

1 reference

12 December 2020

Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics

1 reference

12 December 2020

Postoperative analgesia with morphine with or without diclofenac after shoulder surgery

1 reference

12 December 2020

Obesity and the heart

1 reference

12 December 2020

How individual sensitivity to opiates can be predicted by gene analyses

1 reference

12 December 2020

Long-term changes in energy expenditure and body composition after massive weight loss induced by gastric bypass surgery

1 reference

12 December 2020

Intravenous ciprofloxacin disposition in obesity

1 reference

12 December 2020

Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity

1 reference

12 December 2020

Thiopental disposition in lean and obese patients undergoing surgery.

1 reference

12 December 2020

Association of ABCB1/MDR1 and OPRM1 gene polymorphisms with morphine pain relief.

1 reference

12 December 2020

Sequence variability and candidate gene analysis in complex disease: association of mu opioid receptor gene variation with substance dependence

1 reference

12 December 2020

Influence of renal failure on the disposition of morphine, morphine-3-glucuronide and morphine-6-glucuronide in sheep during intravenous infusion with morphine

1 reference

12 December 2020

Body size and risk of colon and rectal cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC).

1 reference

12 December 2020

Single nucleotide polymorphisms in multidrug resistance associated protein 2 (MRP2/ABCC2): its impact on drug disposition

1 reference

12 December 2020

Vancomycin dosing in morbidly obese patients

1 reference

12 December 2020

Morphine antinociception is enhanced in mdr1a gene-deficient mice

1 reference

12 December 2020

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats

1 reference

12 December 2020

Effects of liver diseases on drug metabolism.

1 reference

12 December 2020

Cytochromes P450 and MDR1 mRNA expression along the human gastrointestinal tract

1 reference

12 December 2020

Total body water data for white adults 18 to 64 years of age: the Fels Longitudinal Study

1 reference

12 December 2020

Effect of body mass index on left ventricular cavity size and ejection fraction

1 reference

12 December 2020

In rats, acute morphine dependence results in antagonist-induced response suppression of intracranial self-stimulation

1 reference

12 December 2020

Environmental and genetic factors associated with morphine response in the postoperative period

1 reference

12 December 2020

Expression of UDP-glucuronosyltransferase isoform mRNAs during inflammation and infection in mouse liver and kidney

1 reference

12 December 2020

Individual differences in pain responses.

1 reference

12 December 2020

Continuous intravenous diclofenac does not induce opioid-sparing or improve analgesia in geriatric patients undergoing major orthopedic surgery

1 reference

12 December 2020

Intestinal drug transporters: in vivo function and clinical importance.

1 reference

12 December 2020

Clinical pharmacology of proton pump inhibitors: what the practising physician needs to know

1 reference

12 December 2020

Effect of P-glycoprotein modulation on the clinical pharmacokinetics and adverse effects of morphine

1 reference

12 December 2020

Diclofenac intramuscular single dose to decrease pain in post operative Caesarean section: a double blind randomized controlled trial

1 reference

12 December 2020

UDP glucuronosyltransferase mRNA levels in human liver disease

1 reference

12 December 2020

Opioids in the nucleus of the solitary tract are involved in feeding in the rat.

1 reference

12 December 2020

Mice lacking multidrug resistance protein 3 show altered morphine pharmacokinetics and morphine-6-glucuronide antinociception

1 reference

12 December 2020

Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine

1 reference

12 December 2020

Level of sensitivity of pain in patients with obesity

1 reference

12 December 2020

Dopamine for "wanting" and opioids for "liking": a comparison of obese adults with and without binge eating

1 reference

12 December 2020

Inflammation and interleukin-6 mediate reductions in the hepatic expression and transcription of the mdr1a and mdr1b Genes.

1 reference

12 December 2020

Surgically affected sulfisoxazole pharmacokinetics in the morbidly obese

1 reference

12 December 2020

Antimicrobial dosing considerations in obese adult patients

1 reference

12 December 2020

Impact of inflammation on the duodenal mRNA expression of CYP3A and P-glycoprotein in children with Crohn's disease.

1 reference

12 December 2020

Computer simulation of the effects of alterations in blood flows and body composition on thiopental pharmacokinetics in humans

1 reference

12 December 2020

Blood-brain barrier permeability to morphine-6-glucuronide is markedly reduced compared with morphine.

1 reference

12 December 2020

Blood circulation in adipose tissue

1 reference

12 December 2020

Are mu-opioid receptor polymorphisms important for clinical opioid therapy?

1 reference

12 December 2020

Multiple and single-dose kinetics of morphine in patients with postoperative pain

1 reference

12 December 2020

10.2165/11317150-000000000-00000

Identifiers

DOI

1 reference

Dimensions Publication ID

21 August 2017

1039413942

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1 reference