(Q37597696)

21 August 2017

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title

Chapter 3: Role of SOCS in allergic and innate immune responses (English)

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21 August 2017

Suzanne L Cassel

1

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PubMed ID

19755183

21 August 2017

Paul B Rothman

series ordinal

2

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21 August 2017

1 January 2009

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21 August 2017

Advances in Immunology

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21 August 2017

103

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21 August 2017

49-76

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The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response

21 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Suppressor of cytokine signaling (SOCS) proteins indirectly regulate toll-like receptor signaling in innate immune cells

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https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Involvement of suppressor of cytokine signaling-3 as a mediator of the inhibitory effects of IL-10 on lipopolysaccharide-induced macrophage activation.

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https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

SOCS5 is expressed in primary B and T lymphoid cells but is dispensable for lymphocyte production and function

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https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Structure of the SOCS4-ElonginB/C Complex Reveals a Distinct SOCS Box Interface and the Molecular Basis for SOCS-Dependent EGFR Degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

SOCS36E, a novel Drosophila SOCS protein, suppresses JAK/STAT and EGF-R signalling in the imaginal wing disc

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Mechanistic and prognostic significance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Pim serine/threonine kinases regulate the stability of Socs-1 protein

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells

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https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Pim-1 and Pim-2 kinases are required for efficient pre-B-cell transformation by v-Abl oncogene

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Suppressor of Cytokine Signaling-1 Regulates Signaling in Response to Interleukin-2 and Other γc-dependent Cytokines in Peripheral T Cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Suppressor of Cytokine Signaling-1 Has IFN- -Independent Actions in T Cell Homeostasis

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https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

T cells and eosinophils in the pathogenesis of asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Suppressors of cytokine signaling (SOCS)-1 and SOCS-3 are induced by CpG-DNA and modulate cytokine responses in APCs

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https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation

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https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

SOCS-1 gene methylation is frequent but does not appear to have prognostic value in patients with multiple myeloma

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Acute exacerbations of asthma: epidemiology, biology and the exacerbation-prone phenotype

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https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

1 reference

7 January 2021

Understanding asthma pathogenesis: linking innate and adaptive immunity.

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https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

A new protein containing an SH2 domain that inhibits JAK kinases

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https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Characterization of a peptide inhibitor of Janus kinase 2 that mimics suppressor of cytokine signaling 1 function

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https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Defective thymocyte development and perturbed homeostasis of T cells in STAT-induced STAT inhibitor-1/suppressors of cytokine signaling-1 transgenic mice

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https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

A regulatory role for suppressor of cytokine signaling-1 in T(h) polarization in vivo

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https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma

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https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses

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https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Understanding the economic burden of asthma

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https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling

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https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

SOCS2 negatively regulates growth hormone action in vitro and in vivo

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https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Functional Polymorphism in theSuppressor of Cytokine Signaling 1Gene Associated with Adult Asthma

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https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Regulation of STAT signalling by proteolytic processing

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https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Twenty proteins containing a C-terminal SOCS box form five structural classes

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https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

The myeloproliferative disorder associated JAK2 V617F mutant escapes negative regulation by suppressor of cytokine signaling 3

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling

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https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

The SOCS box: a tale of destruction and degradation

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https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

SOCS1/JAB is a negative regulator of LPS-induced macrophage activation

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https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Loss of SOCS7 in mice results in severe cutaneous disease and increased mast cell activation.

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https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation

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https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

PIAS1 interacts with the KRAB zinc finger protein, ZNF133, via zinc finger motifs and regulates its transcriptional activity

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https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Insulin induces SOCS-6 expression and its binding to the p85 monomer of phosphoinositide 3-kinase, resulting in improvement in glucose metabolism.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Dendritic cells transduced with SOCS-3 exhibit a tolerogenic/DC2 phenotype that directs type 2 Th cell differentiation in vitro and in vivo

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https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Thymic stromal lymphopoietin: master switch for allergic inflammation

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https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation

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https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

SOCS3 is essential in the regulation of fetal liver erythropoiesis

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https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality

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https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin.

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https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Suppression of STAT5 functions in liver, mammary glands, and T cells in cytokine-inducible SH2-containing protein 1 transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Selective expansion of foxp3-positive regulatory T cells and immunosuppression by suppressors of cytokine signaling 3-deficient dendritic cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Gigantism in mice lacking suppressor of cytokine signalling-2

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https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Structure and function of a new STAT-induced STAT inhibitor

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https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-gamma and IL-4 signaling in vivo

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https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

SOCS-1 participates in negative regulation of LPS responses

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https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

The IL-4 receptor: signaling mechanisms and biologic functions

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https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Methylation silencing of SOCS-3 promotes cell growth and migration by enhancing JAK/STAT and FAK signalings in human hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Overexpression of suppressor of cytokine signalling-5 augments eosinophilic airway inflammation in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

How Toll-like receptors signal: what we know and what we don't know

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

The control of allergic conjunctivitis by suppressor of cytokine signaling (SOCS)3 and SOCS5 in a murine model

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

IL-10 inhibits lipopolysaccharide-induced CD40 gene expression through induction of suppressor of cytokine signaling-3

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Suppressor of cytokine signalling gene expression is elevated in breast carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Two Drosophila suppressors of cytokine signaling (SOCS) differentially regulate JAK and EGFR pathway activities

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Studies with IL-10-/- mice: an overview.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Regulation of liver regeneration and hepatocarcinogenesis by suppressor of cytokine signaling 3

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Genetic reduction of embryonic leukemia-inhibitory factor production rescues placentation in SOCS3-null embryos but does not prevent inflammatory disease

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3

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https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis

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https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Elongin BC complex prevents degradation of von Hippel-Lindau tumor suppressor gene products

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Regulation of JAK-STAT signalling in the immune system

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Tyrosine-phosphorylated SOCS3 interacts with the Nck and Crk-L adapter proteins and regulates Nck activation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

A family of cytokine-inducible inhibitors of signalling

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https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

SOCS3: an essential regulator of LIF receptor signaling in trophoblast giant cell differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Both the suppressor of cytokine signaling 1 (SOCS-1) kinase inhibitory region and SOCS-1 mimetic bind to JAK2 autophosphorylation site: implications for the development of a SOCS-1 antagonist

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Overexpression of suppressor of cytokine signaling-5 in T cells augments innate immunity during septic peritonitis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

SOCS-3 is frequently methylated in head and neck squamous cell carcinoma and its precursor lesions and causes growth inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Immunologic basis of antigen-induced airway hyperresponsiveness

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https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Interleukin-13: central mediator of allergic asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Identification of both positive and negative domains within the epidermal growth factor receptor COOH-terminal region for signal transducer and activator of transcription (STAT) activation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Negative regulation of cytokine signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

The roles of the Drosophila JAK/STAT pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

Distinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2809%2903003-X

7 January 2021

10.1016/S0065-2776(09)03003-X

Identifiers

DOI

1 reference

21 August 2017

1 reference

PubMed ID

19755183