(Q35605437)

9 August 2017

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title

Regulation of JAK-STAT signalling in the immune system (English)

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9 August 2017

Ke Shuai

1

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PubMed ID

14668806

9 August 2017

Bin Liu

series ordinal

2

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9 August 2017

1 November 2003

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Nature Reviews Immunology

9 August 2017

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9 August 2017

3

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9 August 2017

900-911

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9 August 2017

11

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Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

9 August 2017

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STATs and gene regulation

31 March 2020

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Stats: transcriptional control and biological impact

31 March 2020

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How cells respond to interferons

31 March 2020

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Transcription factor p91 interacts with the epidermal growth factor receptor and mediates activation of the c-fos gene promoter

31 March 2020

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Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

31 March 2020

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A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain

31 March 2020

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A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma

31 March 2020

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Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways

31 March 2020

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Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain

31 March 2020

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Enhancement of antiproliferative activity of gamma interferon by the specific inhibition of tyrosine dephosphorylation of Stat1.

31 March 2020

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Biological and clinical significance of the JAK-STAT pathway; lessons from knockout mice.

31 March 2020

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Jaks, STATs, cytokine signal transduction, and immunoregulation: are we there yet?

31 March 2020

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Twenty proteins containing a C-terminal SOCS box form five structural classes

31 March 2020

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Negative regulators of cytokine signal transduction

31 March 2020

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The SOCS box: a tale of destruction and degradation

31 March 2020

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Suppressors of cytokine signalling (SOCS) in the immune system

31 March 2020

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A family of cytokine-inducible inhibitors of signalling

31 March 2020

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A new protein containing an SH2 domain that inhibits JAK kinases

31 March 2020

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Structure and function of a new STAT-induced STAT inhibitor

31 March 2020

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Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction

31 March 2020

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CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2

31 March 2020

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The CIS family: negative regulators of JAK-STAT signaling

31 March 2020

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The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

31 March 2020

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The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

31 March 2020

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SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation

31 March 2020

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Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras

31 March 2020

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Tyrosine phosphorylation disrupts elongin interaction and accelerates SOCS3 degradation

31 March 2020

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Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1.

31 March 2020

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Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice

31 March 2020

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SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine.

31 March 2020

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SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality

31 March 2020

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SOCS3 is essential in the regulation of fetal liver erythropoiesis

31 March 2020

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Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3

31 March 2020

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SOCS3: an essential regulator of LIF receptor signaling in trophoblast giant cell differentiation

31 March 2020

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SOCS3 negatively regulates IL-6 signaling in vivo

31 March 2020

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SOCS3 regulates the plasticity of gp130 signaling

31 March 2020

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IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages

31 March 2020

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Mutational switch of an IL-6 response to an interferon-gamma-like response

31 March 2020

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Structure and function of SH2-domain containing tyrosine phosphatases.

31 March 2020

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Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals

31 March 2020

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Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1

31 March 2020

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Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway

31 March 2020

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CD45: new jobs for an old acquaintance

31 March 2020

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CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling

31 March 2020

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Protein tyrosine phosphatases in signal transduction.

31 March 2020

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TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B

31 March 2020

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Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B.

31 March 2020

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PTP1B regulates leptin signal transduction in vivo

31 March 2020

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The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3

31 March 2020

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Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1.

31 March 2020

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Characterization of specific DNA-binding factors activated by double-stranded RNA as positive regulators of interferon alpha/beta-stimulated genes

31 March 2020

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High-throughput immunoblotting. Ubiquitiin-like protein ISG15 modifies key regulators of signal transduction

31 March 2020

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UBP43 (USP18) specifically removes ISG15 from conjugated proteins

31 March 2020

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Protein ISGylation modulates the JAK-STAT signaling pathway

31 March 2020

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SH2-B family members differentially regulate JAK family tyrosine kinases

31 March 2020

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Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor

31 March 2020

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Activation of transcription by IFN-gamma: tyrosine phosphorylation of a 91-kD DNA binding protein

31 March 2020

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DNA binding controls inactivation and nuclear accumulation of the transcription factor Stat1.

31 March 2020

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Nuclear export signal located within theDNA-binding domain of the STAT1transcription factor

31 March 2020

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Regulated nuclear import of the STAT1 transcription factor by direct binding of importin-alpha

31 March 2020

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Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3.

31 March 2020

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Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation

31 March 2020

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Serine phosphorylation of STATs

31 March 2020

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The p38 mitogen-activated protein kinase pathway and its role in interferon signaling

31 March 2020

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Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-gamma

31 March 2020

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Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcription

31 March 2020

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Involvement of receptor-bound protein methyltransferase PRMT1 in antiviral and antiproliferative effects of type I interferons

31 March 2020

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A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor

31 March 2020

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Cooperation of the transcriptional coactivators CBP and p300 with Stat6

31 March 2020

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Acetylation by histone acetyltransferase CREB-binding protein/p300 of STAT6 is required for transcriptional activation of the 15-lipoxygenase-1 gene

31 March 2020

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Regulation of interferon-gamma-activated STAT1 by the ubiquitin-proteasome pathway

31 March 2020

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The V protein of human parainfluenza virus 2 antagonizes type I interferon responses by destabilizing signal transducer and activator of transcription 2.

31 March 2020

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Selective STAT protein degradation induced by paramyxoviruses requires both STAT1 and STAT2 but is independent of alpha/beta interferon signal transduction

31 March 2020

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Paramyxoviruses SV5 and HPIV2 assemble STAT protein ubiquitin ligase complexes from cellular components.

31 March 2020

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STAT3 ubiquitylation and degradation by mumps virus suppress cytokine and oncogene signaling

31 March 2020

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SUMO modification of STAT1 and its role in PIAS-mediated inhibition of gene activation

31 March 2020

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PIAS proteins promote SUMO-1 conjugation to STAT1

31 March 2020

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Inhibition of Stat1-mediated gene activation by PIAS1

31 March 2020

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Cloning and characterization of Gu/RH-II binding protein

31 March 2020

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Modulation of STAT signaling by STAT-interacting proteins

31 March 2020

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Increased K+ efflux and apoptosis induced by the potassium channel modulatory protein KChAP/PIAS3beta in prostate cancer cells

31 March 2020

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A testis-specific androgen receptor coregulator that belongs to a novel family of nuclear proteins

31 March 2020

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Miz1, a novel zinc finger transcription factor that interacts with Msx2 and enhances its affinity for DNA

31 March 2020

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SAP - a putative DNA-binding motif involved in chromosomal organization

31 March 2020

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SAF-Box, a conserved protein domain that specifically recognizes scaffold attachment region DNA.

31 March 2020

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Specific inhibition of Stat3 signal transduction by PIAS3

31 March 2020

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PIASx is a transcriptional co-repressor of signal transducer and activator of transcription 4

31 March 2020

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A transcriptional corepressor of Stat1 with an essential LXXLL signature motif

31 March 2020

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Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction

31 March 2020

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The intranuclear prolactin/cyclophilin B complex as a transcriptional inducer

31 March 2020

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Physical and functional interactions of histone deacetylase 3 with TFII-I family proteins and PIASxbeta

31 March 2020

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Repression of Smad transcriptional activity by PIASy, an inhibitor of activated STAT.

31 March 2020

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An E3-like factor that promotes SUMO conjugation to the yeast septins

31 March 2020

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Involvement of PIAS1 in the sumoylation of tumor suppressor p53

31 March 2020

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PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies

31 March 2020

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Distinct effects of PIAS proteins on androgen-mediated gene activation in prostate cancer cells

31 March 2020

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A Drosophila PIAS homologue negatively regulates stat92E

31 March 2020

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Identification of Shp-2 as a Stat5A phosphatase

31 March 2020

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Prolactin induces SHP-2 association with Stat5, nuclear translocation, and binding to the beta-casein gene promoter in mammary cells

31 March 2020

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A cytosolic protein-tyrosine phosphatase PTP1B specifically dephosphorylates and deactivates prolactin-activated STAT5a and STAT5b

31 March 2020

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A nuclear tyrosine phosphatase downregulates interferon-induced gene expression

31 March 2020

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A nuclear protein tyrosine phosphatase is required for the inactivation of Stat1.

31 March 2020

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Identification of a nuclear Stat1 protein tyrosine phosphatase

31 March 2020

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SHP-2 is a dual-specificity phosphatase involved in Stat1 dephosphorylation at both tyrosine and serine residues in nuclei

31 March 2020

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Specific ablation of Stat3beta distorts the pattern of Stat3-responsive gene expression and impairs recovery from endotoxic shock

31 March 2020

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Negative regulation of STAT92E by an N-terminally truncated STAT protein derived from an alternative promoter site

31 March 2020

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Sensitization of IFN-γ Jak-STAT signaling during macrophage activation

31 March 2020

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Interferons inhibit activation of STAT6 by interleukin 4 in human monocytes by inducing SOCS-1 gene expression

31 March 2020

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NF-kappaB regulation in the immune system

31 March 2020

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Defective TNF-alpha-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases

31 March 2020

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SOCS1/JAB is a negative regulator of LPS-induced macrophage activation

31 March 2020

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SOCS-1 participates in negative regulation of LPS responses

31 March 2020

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Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor necrosis factor alpha-induced cell death in fibroblasts

31 March 2020

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Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway.

31 March 2020

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Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300

31 March 2020

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PKCepsilon is a permissive link in integrin-dependent IFN-gamma signalling that facilitates JAK phosphorylation of STAT1.

31 March 2020

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Jaks and STATs: biological implications

31 March 2020

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Mutations in severe combined immune deficiency (SCID) due to JAK3 deficiency.

31 March 2020

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Signal transducer and activator of transcription 6 (STAT-6) expression and function in asthmatic bronchial epithelium

31 March 2020

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SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses.

31 March 2020

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Inhibition of IFN-gamma signaling by an Epstein-Barr virus immediate-early protein

31 March 2020

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Human cytomegalovirus inhibits major histocompatibility complex class II expression by disruption of the Jak/Stat pathway

31 March 2020

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Modulation of major histocompatibility class II protein expression by varicella-zoster virus

31 March 2020

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Human interferon-gamma-mediated immunity is a genetically controlled continuous trait that determines the outcome of mycobacterial invasion

31 March 2020

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Impaired response to interferon-alpha/beta and lethal viral disease in human STAT1 deficiency

31 March 2020

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STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity

31 March 2020

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Constitutive STAT3 Activation in Intestinal T Cells from Patients with Crohn's Disease

31 March 2020

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Mechanisms underlying ubiquitination

31 March 2020

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SUMO--nonclassical ubiquitin

31 March 2020

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A new RING for SUMO: wrestling transcriptional responses into nuclear bodies with PIAS family E3 SUMO ligases

31 March 2020

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Impaired bone marrow microenvironment and immune function in T cell protein tyrosine phosphatase-deficient mice

31 March 2020

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Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

31 March 2020

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Severe defects in immunity and hematopoiesis caused by SHP-1 protein-tyrosine-phosphatase deficiency

31 March 2020

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Requirement of Shp-2 tyrosine phosphatase in lymphoid and hematopoietic cell development

31 March 2020

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CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation

31 March 2020

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Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI1226

1 reference

release_3x6dk7m3dvb3xhoqqe3cup3vcm

9 August 2017

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Fatcat

https://api.fatcat.wiki/v0/release/3x6dk7m3dvb3xhoqqe3cup3vcm

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24 November 2022

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PubMed ID

14668806

1 reference

PubMed ID

14668806