(Q37600516)

21 August 2017

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title

The ubiquitin-proteasome pathway and endothelial (dys)function (English)

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ubiquitin-proteasome system

21 August 2017

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author name string

Karl Stangl

series ordinal

1

1 reference

PubMed ID

19767293

21 August 2017

Verena Stangl

series ordinal

2

1 reference

21 August 2017

17 September 2009

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21 August 2017

Cardiovascular Research

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21 August 2017

85

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21 August 2017

2

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21 August 2017

281-290

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The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

21 August 2017

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Ubiquitin-proteasome pathway as a new target for the prevention of restenosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

The possible role of the ubiquitin proteasome system in the development of atherosclerosis in diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Chronic proteasome inhibition contributes to coronary atherosclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Targeting of the proteasome worsens atherosclerosis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

The pathogenesis of atherosclerosis: a perspective for the 1990s

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Intracellular protein degradation from a vague idea through the lysosome and the ubiquitin-proteasome system and on to human diseases and drug targeting: Nobel Lecture, December 8, 2004.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Targeting proteins for destruction by the ubiquitin system: implications for human pathobiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Origin and function of ubiquitin-like proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Generation of major histocompatibility complex class I antigens: functional interplay between proteasomes and TPPII.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

The persisting challenge of selective and specific proteasome inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Proteasome inhibitors: poisons and remedies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Nitric oxide inhibits H2O2-induced transferrin receptor-dependent apoptosis in endothelial cells: Role of ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Nitric oxide mitigates peroxide-induced iron-signaling, oxidative damage, and apoptosis in endothelial cells: role of proteasomal function?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Hydrogen peroxide induces nitric oxide and proteosome activity in endothelial cells: a bell-shaped signaling response

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Upregulation of immunoproteasomes by nitric oxide: potential antioxidative mechanism in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Life history of eNOS: partners and pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Nitric oxide synthases: properties and catalytic mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Endothelial nitric oxide (NO) and its pathophysiologic regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Ubiquitination of neuronal nitric-oxide synthase in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Inducible nitric-oxide synthase is regulated by the proteasome degradation pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Proteolytic degradation of nitric oxide synthase: effect of inhibitors and role of hsp90-based chaperones

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Endothelial nitric oxide synthase in vascular disease: from marvel to menace

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Chaperone-dependent regulation of endothelial nitric-oxide synthase intracellular trafficking by the co-chaperone/ubiquitin ligase CHIP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Long-term up-regulation of eNOS and improvement of endothelial function by inhibition of the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Nontoxic proteasome inhibition activates a protective antioxidant defense response in endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Functional analysis of the human endothelial nitric oxide synthase promoter. Sp1 and GATA factors are necessary for basal transcription in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Hydroxyurea increases eNOS protein levels through inhibition of proteasome activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Involvement of the proteasome in activation of endothelial nitric oxide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Proteasome inhibition down-regulates endothelial nitric-oxide synthase phosphorylation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Proteasome inhibition prevents experimentally-induced endothelial dysfunction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Reconstitution of an endothelial nitric-oxide synthase (eNOS), hsp90, and caveolin-1 complex in vitro. Evidence that hsp90 facilitates calmodulin stimulated displacement of eNOS from caveolin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Dynamic activation of endothelial nitric oxide synthase by Hsp90.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Interaction between the 90-kDa heat shock protein and soluble guanylyl cyclase: physiological significance and mapping of the domains mediating binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Chaperone-dependent E3 ligase CHIP ubiquitinates and mediates proteasomal degradation of soluble guanylyl cyclase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Vasodilator dysfunction in aged spontaneously hypertensive rats: changes in NO synthase III and soluble guanylyl cyclase expression, and in superoxide anion production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Understanding eNOS for pharmacological modulation of endothelial function: a translational view

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Proteasome-dependent degradation of guanosine 5'-triphosphate cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes mellitus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Endothelial dihydrofolate reductase: critical for nitric oxide bioavailability and role in angiotensin II uncoupling of endothelial nitric oxide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

20S proteasome mediated degradation of DHFR: implications in neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Degradation of FAT10 by the 26S proteasome is independent of ubiquitylation but relies on NUB1L.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Laminar shear stress up-regulates inducible nitric oxide synthase in the endothelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Increased expression of iNOS is associated with endothelial dysfunction and impaired pressor responsiveness in streptozotocin-induced diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Vascular protection by tetrahydrobiopterin: progress and therapeutic prospects

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Oxidation of tetrahydrobiopterin by peroxynitrite or oxoferryl species occurs by a radical pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Mechanisms of inducible nitric oxide synthase-mediated vascular dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Protection against lipopolysaccharide-induced endothelial dysfunction in resistance and conduit vasculature of iNOS knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Ubiquitination of inducible nitric oxide synthase is required for its degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

CHIP facilitates ubiquitination of inducible nitric oxide synthase and promotes its proteasomal degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Endothelial dysfunction: from molecular mechanisms to measurement, clinical implications, and therapeutic opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Contribution of endothelium-derived hyperpolarizing factors to the regulation of vascular tone in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Endothelium-dependent contractions in SHR: a tale of prostanoid TP and IP receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Prostanoids and reactive oxygen species: team players in endothelium-dependent contractions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Role of endothelin-1 in the active constriction of human atherosclerotic coronary arteries

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Endothelin-1: the yin and yang on vascular function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Pulmonary release and coronary and peripheral consumption of big endothelin and endothelin-1 in severe heart failure: acute effects of vasodilator therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

A proteasome inhibitor lessens the increased aortic endothelin-1 content in deoxycorticosterone acetate-salt hypertensive rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Involvement of proteasome in endothelin-1 production in cultured vascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Rab1 GTPase and dimerization in the cell surface expression of angiotensin II type 2 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Tyrosine nitration of PA700 activates the 26S proteasome to induce endothelial dysfunction in mice with angiotensin II-induced hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Two distinct pathways for cyclooxygenase-2 protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Regulation of intracellular cyclooxygenase levels by gene transcription and protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

COX-1 and vascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Cyclooxygenase-2-derived prostaglandin F2alpha mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Oxidative stress and COX cause hyper-responsiveness in vascular smooth muscle of the femoral artery from diabetic rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Glucosamine hydrochloride specifically inhibits COX-2 by preventing COX-2 N-glycosylation and by increasing COX-2 protein turnover in a proteasome-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

The ubiquitin- and proteasome-dependent degradation of COX-2 is regulated by the COP9 signalosome and differentially influenced by coxibs

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Focus on prostacyclin and its novel mimetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Role of S3 and S4 transmembrane domain charged amino acids in channel biogenesis and gating of KCa2.3 and KCa3.1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Regulation of nicotinic receptor expression by the ubiquitin-proteasome system

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Endothelial dysfunction through genetic deletion or inhibition of the G protein-coupled receptor Mas: a new target to improve endothelial function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Mechanisms of regulation of the expression and function of G protein-coupled receptor kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Regulated ubiquitination of proteins in GPCR-initiated signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Differential role of beta-arrestin ubiquitination in agonist-promoted down-regulation of M1 vs M2 muscarinic acetylcholine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Adenylate cyclase regulation via proteasome-mediated modulation of Galphas levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Mass spectrometric analysis of type 1 inositol 1,4,5-trisphosphate receptor ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Oxidative stress in vascular disease: causes, defense mechanisms and potential therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Novel isoforms of NADPH oxidase in vascular physiology and pathophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Oxidative modification of proteasome: identification of an oxidation-sensitive subunit in 26 S proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Regulation of proteasome-mediated protein degradation during oxidative stress and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Proteasome inhibition by lipofuscin/ceroid during postmitotic aging of fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Oxidative modification and inactivation of the proteasome during coronary occlusion/reperfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Inactivation of the proteasome by 4-hydroxy-2-nonenal is site specific and dependant on 20S proteasome subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Dysregulation of the ubiquitin-proteasome system in human carotid atherosclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Protection of vascular cells from oxidative stress by proteasome inhibition depends on Nrf2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

Effects of proteasome inhibition on the kidney in experimental hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP315

21 January 2018

Identifiers

DOI

10.1093/CVR/CVP315

1 reference

21 August 2017

1 reference

PubMed ID

19767293