(Q37286190)

19 August 2017

1 reference

title

Targeting proteins for destruction by the ubiquitin system: implications for human pathobiology (English)

1 reference

19 August 2017

2

Aaron Ciechanover

1 reference

19 August 2017

Alan L Schwartz

1

1 reference

19 August 2017

publication date

1 January 2009

1 reference

Annual Review of Pharmacology and Toxicology

19 August 2017

published in

1 reference

19 August 2017

volume

49

1 reference

19 August 2017

page(s)

73-96

1 reference

The proteasome and proteasome inhibitors in cancer therapy

19 August 2017

cites work

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Endocytosis: the DUB version

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11 October 2022

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An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

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11 October 2022

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Impaired proteasome function in Alzheimer's disease

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Biological activities and molecular targets of the human papillomavirus E7 oncoprotein

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Mechanisms of ubiquitin-mediated, limited processing of the NF-kappaB1 precursor protein p105.

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Mechanisms underlying ubiquitination

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

The N-end rule: functions, mysteries, uses

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

The human papillomavirus E6 protein and its contribution to malignant progression

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Ubiquitin: structures, functions, mechanisms

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Validity of 3-methylhistidine excretion as an indicator of skeletal muscle protein breakdown in humans

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

A conserved processing mechanism regulates the activity of transcription factors Cubitus interruptus and NF-κB

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Skeletal muscle hypertrophy and atrophy signaling pathways

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Transglutaminase potentiates ligand-dependent proteasome dysfunction induced by polyglutamine-expanded androgen receptor

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Autophagy: molecular machinery for self-eating

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Impaired oxygen-dependent reduction of HIF-1alpha and -2alpha proteins in pre-eclamptic placentae

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Dose-dependent inhibition of proteasome activity by a mutant ubiquitin associated with neurodegenerative disease

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Leucine incorporation into mixed skeletal muscle protein in humans

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

NF-kappaB regulation in the immune system

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Proteasome inhibition: A novel mechanism to combat asthma

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Increase in ubiquitin-protein conjugates concomitant with the increase in proteolysis in rat skeletal muscle during starvation and atrophy denervation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Complex relationship between Parkin mutations and Parkinson disease

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Increase in levels of polyubiquitin and proteasome mRNA in skeletal muscle during starvation and denervation atrophy

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Measurement of albumin synthesis in humans: a new approach employing stable isotopes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Regulation of angiogenesis by hypoxia-inducible factor 1.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Proteasome inhibition by paired helical filament-tau in brains of patients with Alzheimer's disease

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Hypoxia-Inducible Factor-1 (HIF-1)

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Proteasome-independent functions of ubiquitin in endocytosis and signaling

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

p53 ubiquitination: Mdm2 and beyond

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Identification of ubiquitin ligases required for skeletal muscle atrophy

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Role of the proteasome and NF-kappaB in streptococcal cell wall-induced polyarthritis

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Impairment of the ubiquitin-proteasome system by protein aggregation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Proteasome inhibition ablates activation of NF-kappa B in myocardial reperfusion and reduces reperfusion injury

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Mono- versus polyubiquitination: differential control of p53 fate by Mdm2.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Mutant huntingtin promotes the fibrillogenesis of wild-type huntingtin: a potential mechanism for loss of huntingtin function in Huntington's disease

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Whole-Body Protein Turnover in Preterm Appropriate for Gestational Age and Small for Gestational Age Infants: Comparison of [15N]Glycine and [1-13C]Leucine Administered Simultaneously

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Drug discovery in the ubiquitin-proteasome system.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Ubiquitin pathway in VHL cancer syndrome

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Ubiquitin: tool and target for intracellular NF-kappaB inhibitors.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Degradation of nuclear oncoproteins by the ubiquitin system in vitro

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

NF-kappaB: linking inflammation and immunity to cancer development and progression

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

N-terminal ubiquitination: more protein substrates join in.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Bortezomib or high-dose dexamethasone for relapsed multiple myeloma

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Ubiquitin ligation without a ligase

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Proteasomes: machines for all reasons

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Part I: parkin-associated proteins and Parkinson's disease.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Mechanisms of muscle wasting. The role of the ubiquitin-proteasome pathway

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

ESCRTing proteins in the endocytic pathway

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

The nuclear ubiquitin-proteasome system

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Circulating angiogenic factors and the risk of preeclampsia

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Themes and variations on ubiquitylation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Patterns of gene expression in atrophying skeletal muscles: response to food deprivation.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

IKKbeta/NF-kappaB activation causes severe muscle wasting in mice

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Diverse agents act at multiple levels to inhibit the Rel/NF-kappaB signal transduction pathway

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer's disease-relevant insults

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Human papillomavirus-induced carcinogenesis and the ubiquitin-proteasome system

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Quadrivalent vaccine against human papillomavirus to prevent high-grade cervical lesions

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Proteasome inhibition: a new anti-inflammatory strategy

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Postischemic (6-Hour) treatment with recombinant human tissue plasminogen activator and proteasome inhibitor PS-519 reduces infarction in a rat model of embolic focal cerebral ischemia

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Association of human papillomavirus types 16 and 18 E6 proteins with p53.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

A field guide to ubiquitylation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

The regulation of E2F by pRB-family proteins

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

SCF(beta)(-TrCP) ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Ubiquitin signalling in the NF-kappaB pathway

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

The loss of mdm2 induces p53-mediated apoptosis

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

The role of ubiquitin-protein ligases in neurodegenerative disease

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Quantitative real-time RT-PCR analysis of inflammatory gene expression associated with ischemia-reperfusion brain injury.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Mechanisms of Intracellular Protein Breakdown

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Amyloid beta-protein inhibits ubiquitin-dependent protein degradation in vitro

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Early expression of angiogenesis factors in acute myocardial ischemia and infarction

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Functions of the proteasome: from protein degradation and immune surveillance to cancer therapy

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Inhibitors of the proteasome reduce the accelerated proteolysis in atrophying rat skeletal muscles

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Proteasome inhibitor PS519 reduces infarction and attenuates leukocyte infiltration in a rat model of focal cerebral ischemia

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Regulated portals of entry into the cell

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Mutant ubiquitin found in Alzheimer's disease causes neuritic beading of mitochondria in association with neuronal degeneration

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Energy-ubiquitin-dependent muscle proteolysis during sepsis in rats is regulated by glucocorticoids

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Clinical factors predictive of outcome with bortezomib in patients with relapsed, refractory multiple myeloma

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Autophagosome formation: core machinery and adaptations

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Trinucleotide Repeat Disorders

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Emerging roles for ubiquitin and protein degradation in neuronal function

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

The p53-mdm-2 autoregulatory feedback loop

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Evaluation of HIF-1 inhibitors as anticancer agents

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Whole-body protein turnover in the healthy elderly.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Ubiquitin signals in the NF-kappaB pathway.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

The von Hippel-Lindau tumor suppressor protein

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

A conserved family of prolyl-4-hydroxylases that modify HIF

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

PR-39 and PR-11 peptides inhibit ischemia-reperfusion injury by blocking proteasome-mediated I kappa B alpha degradation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

RACK1 vs. HSP90: competition for HIF-1 alpha degradation vs. stabilization

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Ubiquitin-mediated proteolysis: biological regulation via destruction

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

The aggravating role of the ubiquitin-proteasome system in neurodegenerative disease.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Modification of proteins by ubiquitin and ubiquitin-like proteins

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Extended follow-up of a phase II trial in relapsed, refractory multiple myeloma:: final time-to-event results from the SUMMIT trial

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Sepsis upregulates the gene expression of multiple ubiquitin ligases in skeletal muscle

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Kidney, splanchnic, and leg protein turnover in humans. Insight from leucine and phenylalanine kinetics.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.051208.165340

Identifiers

DOI

10.1146/ANNUREV.PHARMTOX.051208.165340

1 reference

19 August 2017

1 reference