(Q37603369)

21 August 2017

1 reference

title

Endoplasmic reticulum stress in disease: mechanisms and therapeutic opportunities (English)

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21 August 2017

endoplasmic reticulum

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author name string

Toru Hosoi

series ordinal

1

1 reference

PubMed ID

19780718

21 August 2017

Koichiro Ozawa

series ordinal

2

1 reference

PubMed ID

19780718

21 August 2017

language of work or name

English

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publication date

28 September 2009

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21 August 2017

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21 August 2017

118

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21 August 2017

1

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21 August 2017

19-29

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The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins

21 August 2017

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Tripartite management of unfolded proteins in the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Signal integration in the endoplasmic reticulum unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Complexes containing activating transcription factor (ATF)/cAMP-responsive-element-binding protein (CREB) interact with the CCAAT/enhancer-binding protein (C/EBP)-ATF composite site to regulate Gadd153 expression during the stress response

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Regulated translation initiation controls stress-induced gene expression in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

ATF4-mediated induction of 4E-BP1 contributes to pancreatic beta cell survival under endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

One step at a time: endoplasmic reticulum-associated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

ER-associated degradation in protein quality control and cellular regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Akt up- and down-regulation in response to endoplasmic reticulum stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Endoplasmic reticulum stress-induced apoptosis is partly mediated by reduced insulin signaling through phosphatidylinositol 3-kinase/Akt and increased glycogen synthase kinase-3beta in mouse insulinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

PI3K-Akt inactivation induced CHOP expression in endoplasmic reticulum-stressed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

IRE1 signaling affects cell fate during the unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Human caspase 12 has acquired deleterious mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Plasma homocysteine as a risk factor for dementia and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis. GRP78/BiP and novel genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Endoplasmic reticulum stress induces leptin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Herp, a new ubiquitin-like membrane protein induced by endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Activation of the unfolded protein response in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Parkinsonian mimetics induce aspects of unfolded protein response in death of dopaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Changes in endoplasmic reticulum stress proteins and aldolase A in cells exposed to dopamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Sequence of protein disulphide isomerase and implications of its relationship to thioredoxin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Protein disulfide isomerase: multiple roles in the modification of nascent secretory proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

The role of the unfolded protein response in tumour development: friend or foe?

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

De-regulation of GRP stress protein expression in human breast cancer cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Homocysteine increases the expression of vascular endothelial growth factor by a mechanism involving endoplasmic reticulum stress and transcription factor ATF4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

XBP1 is essential for survival under hypoxic conditions and is required for tumor growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Inhibition of tumor progression by suppression of stress protein GRP78/BiP induction in fibrosarcoma B/C10ME.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Hsp90 inhibitors as novel cancer chemotherapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Disruption of the Raf-1-Hsp90 molecular complex results in destabilization of Raf-1 and loss of Raf-1-Ras association

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Positional cloning of the mouse obese gene and its human homologue

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Weight-reducing effects of the plasma protein encoded by the obese gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Effects of the obese gene product on body weight regulation in ob/ob mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Subdiaphragmatic vagotomy fails to inhibit intravenous leptin-induced IL-1beta expression in the hypothalamus

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Divergent signaling capacities of the long and short isoforms of the leptin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Defective STAT signaling by the leptin receptor in diabetic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Activation of the Leptin Receptor by a Ligand-induced Conformational Change of Constitutive Receptor Dimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Identification and expression cloning of a leptin receptor, OB-R

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Leptin regulates interleukin-1beta expression in the brain via the STAT3-independent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Brain stem is a direct target for leptin's action in the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Leptin and the regulation of body weight in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Identification of SOCS-3 as a potential mediator of central leptin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

The role of SOCS-3 in leptin signaling and leptin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

PTP1B regulates leptin signal transduction in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

A molecular chaperone inducer protects neurons from ER stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Proteasome inhibitors disrupt the unfolded protein response in myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Proteasome inhibitor PS-341 induces apoptosis through induction of endoplasmic reticulum stress-reactive oxygen species in head and neck squamous cell carcinoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Endoplasmic reticulum stress inhibition protects against excitotoxic neuronal injury in the rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Translational control is required for the unfolded protein response and in vivo glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Phosphorylation of eukaryotic translation initiation factor 2 mediates apoptosis in response to activation of the double-stranded RNA-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

Endoplasmic reticulum stress plays a central role in development of leptin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20080680

21 January 2018

Identifiers

DOI

10.1042/CS20080680

1 reference

21 August 2017

1 reference

PubMed ID

19780718