(Q34529304)

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Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis

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scholarly article

1 reference

Europe PubMed Central

2 August 2017

Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis (English)

1 reference

Europe PubMed Central

2 August 2017

phosphorylation

1 reference

based on heuristic

inferred from title

apoptotic process

1 reference

based on heuristic

inferred from title

8

object named as

Michael Karin

1 reference

Europe PubMed Central

2 August 2017

author name string

Donalyn Scheuner

1

1 reference

Europe PubMed Central

2 August 2017

Rupali Patel

2

1 reference

Europe PubMed Central

2 August 2017

Feng Wang

3

1 reference

Europe PubMed Central

2 August 2017

Kuei Lee

4

1 reference

Europe PubMed Central

2 August 2017

Kotlo Kumar

5

1 reference

Europe PubMed Central

2 August 2017

Jun Wu

6

1 reference

Europe PubMed Central

2 August 2017

Anders Nilsson

7

1 reference

Europe PubMed Central

2 August 2017

Randal J Kaufman

9

1 reference

Europe PubMed Central

2 August 2017

language of work or name

0 references

publication date

22 May 2006

1 reference

Europe PubMed Central

2 August 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

2 August 2017

281

1 reference

Europe PubMed Central

2 August 2017

21458-21468

1 reference

Europe PubMed Central

2 August 2017

30

1 reference

Europe PubMed Central

2 August 2017

Gene-specific regulation by general translation factors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

Regulation of mRNA translation by protein folding in the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

Phosphorylation of eukaryotic translation initiation factor 2 mediates apoptosis in response to activation of the double-stranded RNA-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

The protein kinase PKR: a molecular clock that sequentially activates survival and death programs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

Induction of apoptosis by double-stranded-RNA-dependent protein kinase (PKR) involves the alpha subunit of eukaryotic translation initiation factor 2 and NF-kappaB.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

Double-stranded RNA and interferon action

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-kappaB

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

An essential role for the interferon-inducible, double-stranded RNA-activated protein kinase PKR in the tumor necrosis factor-induced apoptosis in U937 cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

Translational control is required for the unfolded protein response and in vivo glucose homeostasis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

Double-stranded (ds) RNA binding and not dimerization correlates with the activation of the dsRNA-dependent protein kinase (PKR).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

High-efficiency transformation of mammalian cells by plasmid DNA

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

Perk is essential for translational regulation and cell survival during the unfolded protein response

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

The phosphorylation state of eucaryotic initiation factor 2 alters translational efficiency of specific mRNAs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

Activation of GCN2 in UV-irradiated cells inhibits translation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

The catalytic activity of the eukaryotic initiation factor-2alpha kinase PKR is required to negatively regulate Stat1 and Stat3 via activation of the T-cell protein-tyrosine phosphatase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

Ultraviolet light activates NFkappaB through translational inhibition of IkappaBalpha synthesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

JNK2 and IKKbeta are required for activating the innate response to viral infection

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

Activation of the I kappa B alpha kinase (IKK) complex by double-stranded RNA-binding defective and catalytic inactive mutants of the interferon-inducible protein kinase PKR.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

Complex roles of Stat1 in regulating gene expression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

Apoptosis is promoted by the dsRNA-activated factor (DRAF1) during viral infection independent of the action of interferon or p53.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

Tumor suppressor p53 as a component of the tumor necrosis factor-induced, protein kinase PKR-mediated apoptotic pathway in human promonocytic U937 cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

Down-regulation of p53 by double-stranded RNA modulates the antiviral response

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

NF-kappaB activation by double-stranded-RNA-activated protein kinase (PKR) is mediated through NF-kappaB-inducing kinase and IkappaB kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

Alpha/beta interferons potentiate virus-induced apoptosis through activation of the FADD/Caspase-8 death signaling pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

Essential role for the dsRNA-dependent protein kinase PKR in innate immunity to viral infection

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

Control of alpha subunit of eukaryotic translation initiation factor 2 (eIF2 alpha) phosphorylation by the human papillomavirus type 18 E6 oncoprotein: implications for eIF2 alpha-dependent gene expression and cell death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

PKR, apoptosis and cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

The B56alpha regulatory subunit of protein phosphatase 2A is a target for regulation by double-stranded RNA-dependent protein kinase PKR

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

Defects in translational regulation mediated by the alpha subunit of eukaryotic initiation factor 2 inhibit antiviral activity and facilitate the malignant transformation of human fibroblasts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

Regulatable expression of the interferon-induced double-stranded RNA dependent protein kinase PKR induces apoptosis and fas receptor expression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

The double-stranded RNA-activated protein kinase mediates viral-induced encephalitis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

Caspase knockouts: matters of life and death.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

Absence of tumour necrosis factor facilitates primary and recurrent herpes simplex virus-1 infections

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

Dissection of antiviral and immune regulatory functions of tumor necrosis factor receptors in a chronic lymphocytic choriomeningitis virus infection.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

Role for the double-stranded RNA-activated protein kinase PKR in Ad-TNF-alpha gene therapy in esophageal cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

Molecular pathways of protein synthesis inhibition during brain reperfusion: implications for neuronal survival or death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

Double-stranded RNA-activated protein kinase mediates virus-induced apoptosis: a new role for an old actor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

Excessive Tumor Necrosis Factor Activation After Infarction Contributes to Susceptibility of Myocardial Rupture and Left Ventricular Dysfunction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603784200

21 January 2018

Identifiers

10.1074/JBC.M603784200

1 reference

Europe PubMed Central

2 August 2017

1 reference

Europe PubMed Central

2 August 2017

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