(Q37605869)

21 August 2017

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title

Plasma YKL-40: a potential new cancer biomarker? (English)

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21 August 2017

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Julia S Johansen

1

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21 August 2017

Nicolai A Schultz

series ordinal

2

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21 August 2017

Benny V Jensen

series ordinal

3

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21 August 2017

language of work or name

English

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publication date

1 September 2009

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21 August 2017

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21 August 2017

volume

5

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21 August 2017

issue

7

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21 August 2017

page(s)

1065-1082

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Biomarkers and surrogate endpoints: preferred definitions and conceptual framework

21 August 2017

cites work

1 reference

Identification of proteins secreted by human osteoblastic cells in culture

21 January 2018

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Identification of a 38-kDa heparin-binding glycoprotein (gp38k) in differentiating vascular smooth muscle cells as a member of a group of proteins associated with tissue remodeling

21 January 2018

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Molecular characterization of the gene for human cartilage gp-39 (CHI3L1), a member of the chitinase protein family and marker for late stages of macrophage differentiation

21 January 2018

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Evolution of mammalian chitinase(-like) members of family 18 glycosyl hydrolases.

21 January 2018

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Chitinase family GH18: evolutionary insights from the genomic history of a diverse protein family

21 January 2018

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Family 18 chitolectins: comparison of MGP40 and HUMGP39

21 January 2018

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Crystal structure of a novel regulatory 40-kDa mammary gland protein (MGP-40) secreted during involution

21 January 2018

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YKL-40 (cartilage gp-39) induces proliferative events in cultured chondrocytes and synoviocytes and increases glycosaminoglycan synthesis in chondrocytes

21 January 2018

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An abundantly secreted glycoprotein from Drosophila melanogaster is related to mammalian secretory proteins produced in rheumatoid tissues and by activated macrophages.

21 January 2018

1 reference

The phylogenetically conserved molluscan chitinase-like protein 1 (Cg-Clp1), homologue of human HC-gp39, stimulates proliferation and regulates synthesis of extracellular matrix components of mammalian chondrocytes

21 January 2018

1 reference

Chitotriosidase, a chitinase, and the 39-kDa human cartilage glycoprotein, a chitin-binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages

21 January 2018

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Crystal structure and carbohydrate-binding properties of the human cartilage glycoprotein-39

21 January 2018

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Structure and ligand-induced conformational change of the 39-kDa glycoprotein from human articular chondrocytes

21 January 2018

1 reference

Structural and sequence-based classification of glycoside hydrolases

21 January 2018

1 reference

Transcriptional regulation of CHI3L1, a marker gene for late stages of macrophage differentiation.

21 January 2018

1 reference

Regulation of YKL-40 expression during genotoxic or microenvironmental stress in human glioblastoma cells

21 January 2018

1 reference

Serum YKL-40 concentrations in newly diagnosed multiple myeloma patients and YKL-40 expression in malignant plasma cells

21 January 2018

1 reference

Induction and expression of human cartilage glycoprotein 39 in rheumatoid inflammatory and peripheral blood monocyte-derived macrophages

21 January 2018

1 reference

A combination of proteomics, principal component analysis and transcriptomics is a powerful tool for the identification of biomarkers for macrophage maturation in the U937 cell line.

21 January 2018

1 reference

Gene expression in papillary thyroid carcinoma reveals highly consistent profiles

21 January 2018

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HC gp-39 gene is upregulated in glioblastomas

21 January 2018

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Identification of genes differentially expressed in glioblastoma versus pilocytic astrocytoma using Suppression Subtractive Hybridization.

21 January 2018

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Integrated array-comparative genomic hybridization and expression array profiles identify clinically relevant molecular subtypes of glioblastoma

21 January 2018

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Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis

21 January 2018

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Focused microarray analysis of glyco-gene expression in human glioblastomas.

21 January 2018

1 reference

Anaplastic oligodendrogliomas with 1p19q codeletion have a proneural gene expression profile

21 January 2018

1 reference

Selective repression of YKL-40 by NF-kappaB in glioma cell lines involves recruitment of histone deacetylase-1 and -2.

21 January 2018

1 reference

Studies on the molecular pathogenesis of extraskeletal myxoid chondrosarcoma-cytogenetic, molecular genetic, and cDNA microarray analyses

21 January 2018

1 reference

YKL-40 is a differential diagnostic marker for histologic subtypes of high-grade gliomas.

21 January 2018

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YKL-40 expression is associated with poorer response to radiation and shorter overall survival in glioblastoma.

21 January 2018

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Epidermal growth factor receptor variant III status defines clinically distinct subtypes of glioblastoma

21 January 2018

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Expression of oligodendroglial and astrocytic lineage markers in diffuse gliomas: use of YKL-40, ApoE, ASCL1, and NKX2-2.

21 January 2018

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Prognostic implications of immunohistochemically detected YKL-40 expression in breast cancer

21 January 2018

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YKL-40 protein expression is not a prognostic marker in patients with primary breast cancer.

21 January 2018

1 reference

Gene expression alterations in the non-neoplastic parenchyma adjacent to infiltrating pancreatic ductal adenocarcinoma

21 January 2018

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Human cartilage gp-39+,CD16+ monocytes in peripheral blood and synovium: correlation with joint destruction in rheumatoid arthritis.

21 January 2018

1 reference

Strong induction of members of the chitinase family of proteins in atherosclerosis: chitotriosidase and human cartilage gp-39 expressed in lesion macrophages.

21 January 2018

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A chitinase-like protein in the lung and circulation of patients with severe asthma

21 January 2018

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Increased serum YKL-40 in patients with pulmonary sarcoidosis--a potential marker of disease activity?

21 January 2018

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The proinflammatory CD14+CD16+DR++ monocytes are a major source of TNF.

21 January 2018

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Regulation of YKL-40 production by human articular chondrocytes

21 January 2018

1 reference

Gp38k, a protein synthesized by vascular smooth muscle cells, stimulates directional migration of human umbilical vein endothelial cells.

21 January 2018

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gp38k (CHI3L1) is a novel adhesion and migration factor for vascular cells

21 January 2018

1 reference

Human synovial cells secrete a 39 kDa protein similar to a bovine mammary protein expressed during the non-lactating period

21 January 2018

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The synovial proteome: analysis of fibroblast-like synoviocytes

21 January 2018

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Chitinase 3-like-1 exacerbates intestinal inflammation by enhancing bacterial adhesion and invasion in colonic epithelial cells.

21 January 2018

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Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function

21 January 2018

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Functional variants in the promoter region of Chitinase 3-like 1 (CHI3L1) and susceptibility to schizophrenia.

21 January 2018

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Chitinase-3-like 1 (CHI3L1) gene and schizophrenia: genetic association and a potential functional mechanism

21 January 2018

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No association of (-131C-->G) variant of CHI3L1 gene with risk of glioblastoma and prognosis.

21 January 2018

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Variation in CHI3LI in relation to type 2 diabetes and related quantitative traits

21 January 2018

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Serum YKL-40, a new prognostic biomarker in cancer patients?

21 January 2018

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Is YKL-40 a new therapeutic target in cancer?

21 January 2018

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The chitinase 3-like protein human cartilage glycoprotein 39 (HC-gp39) stimulates proliferation of human connective-tissue cells and activates both extracellular signal-regulated kinase- and protein kinase B-mediated signalling pathways

21 January 2018

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Inflammatory cytokines induce production of CHI3L1 by articular chondrocytes

21 January 2018

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The chitinase 3-like protein human cartilage glycoprotein 39 inhibits cellular responses to the inflammatory cytokines interleukin-1 and tumour necrosis factor-alpha

21 January 2018

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Prognostic associations of activated mitogen-activated protein kinase and Akt pathways in glioblastoma.

21 January 2018

1 reference

Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing

21 January 2018

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Inflammation and cancer: back to Virchow?

21 January 2018

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Smoldering and polarized inflammation in the initiation and promotion of malignant disease

21 January 2018

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21 January 2018

Inflammation and cancer

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Proteases, extracellular matrix, and cancer: a workshop of the path B study section

21 January 2018

1 reference

Mechanisms of disease: Inflammation and the origins of cancer

21 January 2018

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Paradoxical roles of the immune system during cancer development

21 January 2018

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Tumor stroma and regulation of cancer development

21 January 2018

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A cytokine-mediated link between innate immunity, inflammation, and cancer

21 January 2018

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The role of fibroblasts in tumor behavior

21 January 2018

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Putting tumours in context

21 January 2018

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Tumor reversion: Correction of malignant behavior by microenvironmental cues

21 January 2018

1 reference

Cytokines in cancer pathogenesis and cancer therapy

21 January 2018

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Tumour vascularization: sprouting angiogenesis and beyond

21 January 2018

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Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis

21 January 2018

1 reference

Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway

21 January 2018

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The mammalian chitinase-like lectin, YKL-40, binds specifically to type I collagen and modulates the rate of type I collagen fibril formation.

21 January 2018

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Cells expressing the DG42 gene from early Xenopus embryos synthesize hyaluronan

21 January 2018

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Homologs of the Xenopus developmental gene DG42 are present in zebrafish and mouse and are involved in the synthesis of Nod-like chitin oligosaccharides during early embryogenesis

21 January 2018

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Does DG42 synthesize hyaluronan or chitin?: A controversy about oligosaccharides in vertebrate development

21 January 2018

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Hyaluronan: from extracellular glue to pericellular cue.

21 January 2018

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Decreasing the metastatic potential in cancers--targeting the heparan sulfate proteoglycans

21 January 2018

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T cell responses to a human cartilage autoantigen in the context of rheumatoid arthritis-associated and nonassociated HLA-DR4 alleles

21 January 2018

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Autoantigenic HCgp39 epitopes are presented by the HLA-DM-dependent presentation pathway in human B cells

21 January 2018

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Localization of MHC class II/human cartilage glycoprotein-39 complexes in synovia of rheumatoid arthritis patients using complex-specific monoclonal antibodies

21 January 2018

1 reference

Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis

21 January 2018

1 reference

YKL-40, a marker of simian immunodeficiency virus encephalitis, modulates the biological activity of basic fibroblast growth factor

21 January 2018

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YKL-40: a candidate biomarker for simian immunodeficiency virus and human immunodeficiency virus encephalitis?

21 January 2018

1 reference

Is the sugar always sweet in intestinal inflammation?

21 January 2018

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Chitinase 3-like-1 enhances bacterial adhesion to colonic epithelial cells through the interaction with bacterial chitin-binding protein

21 January 2018

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YKL-40: a novel marker shared by chronic inflammation and oncogenic transformation

21 January 2018

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Serum YKL-40 levels in healthy children and adults. Comparison with serum and synovial fluid levels of YKL-40 in patients with osteoarthritis or trauma of the knee joint.

21 January 2018

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Stability of YKL-40 concentration in blood samples

21 January 2018

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A new biochemical marker for joint injury. Analysis of YKL-40 in serum and synovial fluid.

21 January 2018

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High serum YKL-40 level in a cohort of octogenarians is associated with increased risk of all-cause mortality.

21 January 2018

1 reference

Acute-phase proteins and other systemic responses to inflammation

21 January 2018

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What does minor elevation of C-reactive protein signify?

21 January 2018

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YKL-40, a matrix protein of specific granules in neutrophils, is elevated in serum of patients with community-acquired pneumonia requiring hospitalization

21 January 2018

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Serum level of YKL-40 is elevated in patients with Streptococcus pneumoniae bacteremia and is associated with the outcome of the disease

21 January 2018

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Circulating YKL-40 levels during human endotoxaemia.

21 January 2018

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Serum YKL-40 concentrations in patients with rheumatoid arthritis: relation to disease activity

21 January 2018

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Raised human cartilage glycoprotein-39 plasma levels in patients with rheumatoid arthritis and other inflammatory conditions

21 January 2018

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YKL-40 is elevated in patients with chronic obstructive pulmonary disease and activates alveolar macrophages

21 January 2018

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High serum levels of YKL-40 in patients with systemic sclerosis are associated with pulmonary involvement.

21 January 2018

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YKL-40, a biomarker of inflammation, is elevated in patients with type 2 diabetes and is related to insulin resistance.

21 January 2018

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Plasma YKL-40: a BMI-independent marker of type 2 diabetes

21 January 2018

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YKL-40, a marker of inflammation and endothelial dysfunction, is elevated in patients with type 1 diabetes and increases with levels of albuminuria

21 January 2018

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Serum YKL-40 levels in patients with coronary artery disease.

21 January 2018

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High serum YKL-40 concentration is associated with cardiovascular and all-cause mortality in patients with stable coronary artery disease.

21 January 2018

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Serum human cartilage glycoprotein 39 as a marker of arthritis associated with inflammatory bowel disease.

21 January 2018

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Serum levels of YKL-40 and PIIINP as prognostic markers in patients with alcoholic liver disease.

21 January 2018

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Effect of antiviral therapy on markers of fibrogenesis in patients with chronic hepatitis C.

21 January 2018

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HIV infection does not affect the performance of noninvasive markers of fibrosis for the diagnosis of hepatitis C virus-related liver disease

21 January 2018

1 reference

Effect of iron depletion on serum markers of fibrogenesis, oxidative stress and serum liver enzymes in chronic hepatitis C: results of a pilot study

21 January 2018

1 reference

Evaluation of serum biomarkers of fibrosis and injury in Egyptian patients with chronic hepatitis C.

21 January 2018

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Relationship of serum fibrosis markers with liver fibrosis stage and collagen content in patients with advanced chronic hepatitis C.

21 January 2018

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Serum fibrosis marker levels decrease after successful antiviral treatment in chronic hepatitis C patients with advanced fibrosis

21 January 2018

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Serum fibrosis markers can predict rapid fibrosis progression after liver transplantation for hepatitis C.

21 January 2018

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Diagnostic accuracy of serum hyaluronic acid, FIBROSpect II, and YKL-40 for discriminating fibrosis stages in chronic hepatitis C.

21 January 2018

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Serum levels of YKL-40 and hyaluronic acid as noninvasive markers of liver fibrosis in haemodialysis patients with chronic hepatitis C virus infection.

21 January 2018

1 reference

Plasma tissue inhibitor of metalloproteinases-1 (TIMP-1): a novel biological marker in the detection of primary colorectal cancer. Protocol outlines of the Danish-Australian endoscopy study group on colorectal cancer detection

21 January 2018

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High serum YKL-40 levels in patients with primary breast cancer is related to short recurrence free survival

21 January 2018

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Serum YKL-40 levels as a prognostic factor in patients with locally advanced breast cancer

21 January 2018

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Serum YKL-40 and colorectal cancer.

21 January 2018

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High serum YKL-40 level after surgery for colorectal carcinoma is related to short survival

21 January 2018

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Early detection and prognosis of ovarian cancer using serum YKL-40.

21 January 2018

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YKL-40 tissue expression and plasma levels in patients with ovarian cancer

21 January 2018

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Serum YKL-40 as a marker for cervical adenocarcinoma.

21 January 2018

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YKL-40 and matrix metalloproteinase-9 as potential serum biomarkers for patients with high-grade gliomas.

21 January 2018

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Elevated serum level of YKL-40 is an independent prognostic factor for poor survival in patients with metastatic melanoma

21 January 2018

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Serum YKL-40 and bone marrow angiogenesis in multiple myeloma.

21 January 2018

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Serum YKL-40 and interleukin 6 levels in Hodgkin lymphoma

21 January 2018

1 reference

2000 update of recommendations for the use of tumor markers in breast and colorectal cancer: clinical practice guidelines of the American Society of Clinical Oncology

21 January 2018

1 reference

Tumor marker utility grading system: a framework to evaluate clinical utility of tumor markers

21 January 2018

1 reference

A functional variation in CHI3L1 is associated with severity of liver fibrosis and YKL-40 serum levels in chronic hepatitis C infection

21 January 2018

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Preoperative serum YKL-40 is a marker for detection and prognosis of endometrial cancer

21 January 2018

1 reference

Clusterin plays an important role in hepatocellular carcinoma metastasis

21 January 2018

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21 January 2018

1 reference

Multiplexed proximity ligation assays to profile putative plasma biomarkers relevant to pancreatic and ovarian cancer

21 January 2018

1 reference

1 April 2022

https://opencitations.net/index/coci/api/v1/citations/10.1373/CLINCHEM.2007.093195

Identifiers

DOI

10.2217/FON.09.66

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21 August 2017

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