(Q37644190)

21 August 2017

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title

Therapeutic potential of complement modulation (English)

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21 August 2017

Eric Wagner

1

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21 August 2017

Michael M Frank

series ordinal

2

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21 August 2017

publication date

4 December 2009

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Nature Reviews Drug Discovery

21 August 2017

published in

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21 August 2017

volume

9

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21 August 2017

issue

1

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21 August 2017

page(s)

43-56

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https://scigraph.springernature.com/pub.10.1038/nrd3011

21 August 2017

exact match

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Proinflammatory events are associated with significant increases in breadth and strength of HLA-specific antibody

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High-dose intravenous immunoglobulin exerts its beneficial effect in patients with dermatomyositis by blocking endomysial deposition of activated complement fragments

31 March 2020

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Ambivalent effect of immunoglobulins on the complement system: activation versus inhibition

31 March 2020

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Intravenous immunoglobulin (IVIG) protects the brain against experimental stroke by preventing complement-mediated neuronal cell death

31 March 2020

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Soluble human complement receptor type 1: in vivo inhibitor of complement suppressing post-ischemic myocardial inflammation and necrosis

31 March 2020

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The use of TP10, soluble complement receptor 1, in cardiopulmonary bypass

31 March 2020

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Preclinical evaluation of the neuroprotective effect of soluble complement receptor type 1 in a nonhuman primate model of reperfused stroke.

31 March 2020

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31 March 2020

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Therapeutic strategy with a membrane-localizing complement regulator to increase the number of usable donor organs after prolonged cold storage

31 March 2020

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Coupling complement regulators to immunoglobulin domains generates effective anti-complement reagents with extended half-life in vivo.

31 March 2020

1 reference

Pharmacological complement inhibition at the C3 convertase level promotes neuronal survival, neuroprotective intracerebral gene expression, and neurological outcome after traumatic brain injury.

31 March 2020

1 reference

Prevention of experimental autoimmune myasthenia gravis by rat Crry-Ig: A model agent for long-term complement inhibition in vivo

31 March 2020

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A novel targeted inhibitor of the alternative pathway of complement and its therapeutic application in ischemia/reperfusion injury

31 March 2020

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A novel inhibitor of the alternative pathway of complement reverses inflammation and bone destruction in experimental arthritis

31 March 2020

1 reference

Complement receptor 2-mediated targeting of complement inhibitors to sites of complement activation

31 March 2020

1 reference

Low-dose targeted complement inhibition protects against renal disease and other manifestations of autoimmune disease in MRL/lpr mice

31 March 2020

1 reference

Complement 3d: from molecular adjuvant to target of immune escape mechanisms.

31 March 2020

1 reference

C3d-defined complement receptor-binding peptide p28 conjugated to circumsporozoite protein provides protection against Plasmodium berghei.

31 March 2020

1 reference

Low doses of antigen coupled to anti-CR2 mAbs induce rapid and enduring IgG immune responses in mice and in cynomolgus monkeys

31 March 2020

1 reference

Inhibition of C5a-induced inflammation with preserved C5b-9-mediated bactericidal activity in a human whole blood model of meningococcal sepsis.

31 March 2020

1 reference

Genentech makes its first-ever acquisition

31 March 2020

1 reference

Treatment with an inhibitory monoclonal antibody to mouse factor B protects mice from induction of apoptosis and renal ischemia/reperfusion injury.

31 March 2020

1 reference

Inhibition of the alternative complement activation pathway in traumatic brain injury by a monoclonal anti-factor B antibody: a randomized placebo-controlled study in mice

31 March 2020

1 reference

Factor B of the alternative complement pathway regulates development of airway hyperresponsiveness and inflammation

31 March 2020

1 reference

Structural and Functional Analysis of a C3b-specific Antibody That Selectively Inhibits the Alternative Pathway of Complement

31 March 2020

1 reference

Derivation of RNA aptamer inhibitors of human complement C5.

31 March 2020

1 reference

Structure of compstatin in complex with complement component C3c reveals a new mechanism of complement inhibition

31 March 2020

1 reference

Blocking the receptor for C5a in patients with rheumatoid arthritis does not reduce synovial inflammation

31 March 2020

1 reference

Anaphylatoxin C3a enhances mucous glycoprotein release from human airways in vitro

31 March 2020

1 reference

Absence of the complement anaphylatoxin C3a receptor suppresses Th2 effector functions in a murine model of pulmonary allergy.

31 March 2020

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Cutting edge: the absence of C3 demonstrates a role for complement in Th2 effector functions in a murine model of pulmonary allergy

31 March 2020

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Complement activation pathways: a bridge between innate and adaptive immune responses in asthma

31 March 2020

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The C3a receptor antagonist SB 290157 has agonist activity

31 March 2020

1 reference

Mobilization studies in mice deficient in either C3 or C3a receptor (C3aR) reveal a novel role for complement in retention of hematopoietic stem/progenitor cells in bone marrow

31 March 2020

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Systemic and lung physiological changes in rats after intravascular activation of complement

31 March 2020

1 reference

Complement evasion by human pathogens

31 March 2020

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Staphylococcal complement evasion by various convertase-blocking molecules.

31 March 2020

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Inhibition of complement and CD14 attenuates the Escherichia coli-induced inflammatory response in porcine whole blood

31 March 2020

1 reference

Smallpox inhibitor of complement enzymes (SPICE): regulation of complement activation on cells and mechanism of its cellular attachment

31 March 2020

1 reference

Hereditary deficiency of the third component of complement in a child with fever, skin rash, and arthralgias: Response to transfusion of whole blood

31 March 2020

1 reference

Infusion of plasma-derived mannan-binding lectin (MBL) into MBL-deficient humans

31 March 2020

1 reference

Phase I safety, tolerability, and pharmacokinetic study of recombinant human mannan-binding lectin

31 March 2020

1 reference

Human Mannose-binding Lectin in Immunity: Friend, Foe, or Both?

31 March 2020

1 reference

Drug design using the example of the complement system inhibitors' development

31 March 2020

1 reference

Humanization of yeast to produce complex terminally sialylated glycoproteins

31 March 2020

1 reference

C1, MBL-MASPs and C1-inhibitor: novel approaches for targeting complement-mediated inflammation

31 March 2020

1 reference

Translational mini-review series on complement factor H: renal diseases associated with complement factor H: novel insights from humans and animals.

31 March 2020

1 reference

Clinical aspects and molecular basis of primary deficiencies of complement component C3 and its regulatory proteins factor I and factor H.

31 March 2020

1 reference

Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphism

31 March 2020

1 reference

Complement regulatory genes and hemolytic uremic syndromes

31 March 2020

1 reference

Therapeutic inhibition of the complement system.

31 March 2020

1 reference

12 December 2020

Soluble human complement receptor 1 limits ischemic damage in cardiac surgery patients at high risk requiring cardiopulmonary bypass.

1 reference

12 December 2020

Drug evaluation: the C5a receptor antagonist PMX-53.

1 reference

12 December 2020

Therapeutic inhibition of the complement system. Y2K update

1 reference

12 December 2020

The use of antibody to complement protein C5 for salvage treatment of severe antibody-mediated rejection

1 reference

12 December 2020

C4 binding protein deficiency in a patient with atypical Behçet's disease

1 reference

12 December 2020

Functional characterization of human C3/cobra venom factor hybrid proteins for therapeutic complement depletion.

1 reference

12 December 2020

Synthetic small-molecule complement inhibitors.

1 reference

12 December 2020

Complement factor 1 inhibitor improves cardiopulmonary function in neonatal cardiopulmonary bypass

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRD3011

1 reference

21 August 2017

1 reference