(Q37659998)

21 August 2017

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title

Polypeptide-polymer bioconjugates (English)

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21 August 2017

Luiz A Canalle

1

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21 August 2017

Dennis W P M Löwik

series ordinal

2

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21 August 2017

Jan C M van Hest

series ordinal

3

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21 August 2017

publication date

6 October 2009

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21 August 2017

published in

Chemical Society Reviews

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21 August 2017

volume

39

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21 August 2017

issue

1

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21 August 2017

page(s)

329-353

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PEGylation, successful approach to drug delivery

21 August 2017

cites work

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Effect of pegylation on pharmaceuticals

21 January 2018

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Chemistry for peptide and protein PEGylation

21 January 2018

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Polymer conjugates as anticancer nanomedicines

21 January 2018

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Peptide/protein-polymer conjugates: synthetic strategies and design concepts.

21 January 2018

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Controlled/living radical polymerization: Features, developments, and perspectives

21 January 2018

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Characterization and stability of N-terminally PEGylated rhG-CSF.

21 January 2018

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Pharmacokinetic and biodistribution properties of poly(ethylene glycol)–protein conjugates

21 January 2018

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PEGylated antibodies and antibody fragments for improved therapy: a review

21 January 2018

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Structure-function engineering of interferon-beta-1b for improving stability, solubility, potency, immunogenicity, and pharmacokinetic properties by site-selective mono-PEGylation

21 January 2018

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Synthesis of poly(ethylene glycol)-silk fibroin conjugates and surface interaction between L-929 cells and the conjugates

21 January 2018

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Reduction of fibrinogen adsorption on PEG-coated polystyrene surfaces

21 January 2018

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Surface modification of proteins. Activation of monomethoxy-polyethylene glycols by phenylchloroformates and modification of ribonuclease and superoxide dismutase.

21 January 2018

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Microwave-assisted synthesis of thiophene fluorophores, labeling and multilabeling of monoclonal antibodies, and long lasting staining of fixed cells

21 January 2018

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Amide bond formation: beyond the myth of coupling reagents

21 January 2018

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Design and chemical synthesis of a homogeneous polymer-modified erythropoiesis protein

21 January 2018

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Peptide/protein hybrid materials: enhanced control of structure and improved performance through conjugation of biological and synthetic polymers

21 January 2018

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Preparation and characterization of active site protected poly(ethylene glycol)-avidin bioconjugates

21 January 2018

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Site-specific PEGylation of a lysine-deficient TNF-alpha with full bioactivity

21 January 2018

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Optimal site-specific PEGylation of mutant TNF-alpha improves its antitumor potency

21 January 2018

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Functionalization of tumor necrosis factor-alpha using phage display technique and PEGylation improves its antitumor therapeutic window

21 January 2018

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Isolation from phage display libraries of lysine-deficient human epidermal growth factor variants for directional conjugation as targeting ligands

21 January 2018

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A general method for highly selective cross-linking of unprotected polypeptides via pH-controlled modification of N-terminal alpha-amino groups

21 January 2018

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N-terminally PEGylated human interferon-beta-1a with improved pharmacokinetic properties and in vivo efficacy in a melanoma angiogenesis model.

21 January 2018

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Modification of CD4 immunoadhesin with monomethoxypoly(ethylene glycol) aldehyde via reductive alkylation

21 January 2018

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Covalent attachment of lactase to low-density polyethylene films

21 January 2018

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Mono-N-terminal poly(ethylene glycol)-protein conjugates

21 January 2018

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High-performance affinity monolith chromatography: development and evaluation of human serum albumin columns

21 January 2018

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Reductive alkylation of proteins using iridium catalyzed transfer hydrogenation

21 January 2018

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Submicron streptavidin patterns for protein assembly

21 January 2018

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Site-specific chemical modification with polyethylene glycol of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) improves antitumor activity and reduces animal toxicity and immunogenicity

21 January 2018

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Systematic modulation of Michael-type reactivity of thiols through the use of charged amino acids

21 January 2018

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Preparation of characterization of poly(ethylene glycol) vinyl sulfone

21 January 2018

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Recombinant protein-co-PEG networks as cell-adhesive and proteolytically degradable hydrogel matrixes. Part I: Development and physicochemical characteristics

21 January 2018

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RGD-grafted poly-L-lysine-graft-(polyethylene glycol) copolymers block non-specific protein adsorption while promoting cell adhesion

21 January 2018

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Size-dependent control of the binding of biotinylated proteins to streptavidin using a polymer shield.

21 January 2018

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Photoswitching of ligand association with a photoresponsive polymer-protein conjugate

21 January 2018

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Temperature-induced switching of enzyme activity with smart polymer-enzyme conjugates

21 January 2018

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Photoresponsive polymer-enzyme switches

21 January 2018

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Design and synthesis of N-maleimido-functionalized hydrophilic polymers via copper-mediated living radical polymerization: a suitable alternative to PEGylation chemistry

21 January 2018

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Site-specific immobilization of genetically engineered variants of Candida antarctica lipase B.

21 January 2018

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Precisely defined protein-polymer conjugates: construction of synthetic DNA binding domains on proteins by using multivalent dendrons

21 January 2018

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Photochemical surface patterning by the thiol-ene reaction

21 January 2018

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Cysteine-reactive polymers synthesized by atom transfer radical polymerization for conjugation to proteins

21 January 2018

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Antibody linking to atomic force microscope tips via disulfide bond formation

21 January 2018

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Covalent immobilization of antibody fragments on well-defined polymer brushes via site-directed method

21 January 2018

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Site-specific dense immobilization of antibody fragments on polymer brushes supported by silicone nanofilaments

21 January 2018

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Protected thiol-polyethylene glycol: a new activated polymer for reversible protein modification

21 January 2018

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Site-specific PEGylation of native disulfide bonds in therapeutic proteins.

21 January 2018

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Disulfide bridge based PEGylation of proteins

21 January 2018

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A three-component Mannich-type reaction for selective tyrosine bioconjugation.

21 January 2018

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Tyrosine-selective protein alkylation using pi-allylpalladium complexes.

21 January 2018

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Intein-mediated protein ligation: harnessing nature's escape artists

21 January 2018

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Synthesis of proteins by native chemical ligation

21 January 2018

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Extending the scope of native chemical peptide coupling

21 January 2018

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Native chemical ligation at valine

21 January 2018

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Branched KLVFF tetramers strongly potentiate inhibition of beta-amyloid aggregation.

21 January 2018

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Site-specific protein and peptide immobilization on a biosensor surface by pulsed native chemical ligation.

21 January 2018

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Site-specific attachment of polyethylene glycol-like oligomers to proteins and peptides.

21 January 2018

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Enzymatic procedure for site-specific pegylation of proteins

21 January 2018

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Transglutaminases: nature's biological glues

21 January 2018

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Site-specific modification and PEGylation of pharmaceutical proteins mediated by transglutaminase.

21 January 2018

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Exploring enzymatic catalysis at a solid surface: a case study with transglutaminase-mediated protein immobilization

21 January 2018

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GlycoPEGylation of recombinant therapeutic proteins produced in Escherichia coli.

21 January 2018

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Protein-functionalized polymer brushes

21 January 2018

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A general method for the covalent labeling of fusion proteins with small molecules in vivo

21 January 2018

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An engineered protein tag for multiprotein labeling in living cells

21 January 2018

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Specific covalent labeling of recombinant protein molecules inside live cells

21 January 2018

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The growing impact of click chemistry on drug discovery

21 January 2018

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Cu-catalyzed azide-alkyne cycloaddition

21 January 2018

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Bioconjugation by copper(I)-catalyzed azide-alkyne [3 + 2] cycloaddition

21 January 2018

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Site-specific PEGylation of proteins containing unnatural amino acids

21 January 2018

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Incorporation of azides into recombinant proteins for chemoselective modification by the Staudinger ligation

21 January 2018

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Site-specific modification of Candida antarctica lipase B via residue-specific incorporation of a non-canonical amino acid

21 January 2018

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An efficient, inexpensive, and shelf-stable diazotransfer reagent: imidazole-1-sulfonyl azide hydrochloride

21 January 2018

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Single-step azide introduction in proteins via an aqueous diazo transfer

21 January 2018

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Preparation of biohybrid amphiphiles via the copper catalysed Huisgen [3 + 2] dipolar cycloaddition reaction

21 January 2018

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Soft hydrogels from nanotubes of poly(ethylene oxide)-tetraphenylalanine conjugates prepared by click chemistry

21 January 2018

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Virus-glycopolymer conjugates by copper(I) catalysis of atom transfer radical polymerization and azide-alkyne cycloaddition

21 January 2018

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PEG- and peptide-grafted aliphatic polyesters by click chemistry

21 January 2018

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Carbohydrate and protein immobilization onto solid surfaces by sequential Diels-Alder and azide-alkyne cycloadditions

21 January 2018

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Oxidative mechanisms in the toxicity of metal ions

21 January 2018

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Über neue organische Phosphorverbindungen III. Phosphinmethylenderivate und Phosphinimine

21 January 2018

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Cell surface engineering by a modified Staudinger reaction

21 January 2018

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C-terminal site-specific PEGylation of a truncated thrombomodulin mutant with retention of full bioactivity

21 January 2018

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Reactivity of intein thioesters: appending a functional group to a protein

21 January 2018

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A "traceless" Staudinger ligation for the chemoselective synthesis of amide bonds

21 January 2018

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Staudinger ligation: a peptide from a thioester and azide.

21 January 2018

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Water-soluble phosphinothiols for traceless staudinger ligation and integration with expressed protein ligation

21 January 2018

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Protein assembly by orthogonal chemical ligation methods

21 January 2018

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Carbohydrate-specifically polyethylene glycol-modified ricin A-chain with improved therapeutic potential

21 January 2018

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Single-chain Fv with manifold N-glycans as bifunctional scaffolds for immunomolecules

21 January 2018

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A designed phenylalanyl-tRNA synthetase variant allows efficient in vivo incorporation of aryl ketone functionality into proteins

21 January 2018

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A new strategy for the site-specific modification of proteins in vivo.

21 January 2018

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Dual-surface modification of the tobacco mosaic virus

21 January 2018

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Dual-surface-modified bacteriophage MS2 as an ideal scaffold for a viral capsid-based drug delivery system.

21 January 2018

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N-terminal protein modification through a biomimetic transamination reaction.

21 January 2018

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Synthetic erythropoietic proteins: tuning biological performance by site-specific polymer attachment

21 January 2018

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A chemical approach to the pharmaceutical optimization of an anti-HIV protein.

21 January 2018

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Nucleophilic catalysis of oxime ligation

21 January 2018

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Site-specific polymer attachment to a CCL-5 (RANTES) analogue by oxime exchange

21 January 2018

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Immobilization of ligands with precise control of density to electroactive surfaces

21 January 2018

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An interfacial oxime reaction to immobilize ligands and cells in patterns and gradients to photoactive surfaces

21 January 2018

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Application of metal-free triazole formation in the synthesis of cyclic RGD-DTPA conjugates

21 January 2018

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Copper-free click chemistry for dynamic in vivo imaging

21 January 2018

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Visualizing metabolically labeled glycoconjugates of living cells by copper-free and fast huisgen cycloadditions.

21 January 2018

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Metal-free triazole formation as a tool for bioconjugation

21 January 2018

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Selective functionalization of a genetically encoded alkene-containing protein via "photoclick chemistry" in bacterial cells

21 January 2018

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Copper-free "click" modification of DNA via nitrile oxide-norbornene 1,3-dipolar cycloaddition

21 January 2018

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Protein C-terminal modification through thioacid/azide amidation

21 January 2018

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Tetrazine ligation: fast bioconjugation based on inverse-electron-demand Diels-Alder reactivity

21 January 2018

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Tetrazine-based cycloadditions: application to pretargeted live cell imaging

21 January 2018

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The avidin-biotin complex in bioanalytical applications

21 January 2018

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Reversible meso-scale smart polymer--protein particles of controlled sizes

21 January 2018

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The effect of polymer chain length and surface density on the adhesiveness of functionalized polymersomes

21 January 2018

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Controlling the aggregation of conjugates of streptavidin with smart block copolymers prepared via the RAFT copolymerization technique

21 January 2018

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Biotin reagents for antibody pretargeting. 3. Synthesis, radioiodination, and evaluation of biotinylated starburst dendrimers

21 January 2018

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Chain-end functionalized nanopatterned polymer brushes grown via in situ nitroxide free radical exchange

21 January 2018

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Facile synthesis of chain-end functionalized glycopolymers for site-specific bioconjugation

21 January 2018

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Design and synthesis of biotin chain-terminated glycopolymers for surface glycoengineering

21 January 2018

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One-step synthesis of low polydispersity, biotinylated poly(N-isopropylacrylamide) by ATRP.

21 January 2018

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Determination of the bioavailability of biotin conjugated onto shell cross-linked (SCK) nanoparticles

21 January 2018

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Biotinylated glycopolymers synthesized by atom transfer radical polymerization

21 January 2018

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Versatile precursors of functional RAFT agents. Application to the synthesis of bio-related end-functionalized polymers.

21 January 2018

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Growth factor mediated assembly of cell receptor-responsive hydrogels

21 January 2018

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Designed amino acid ATRP initiators for the synthesis of biohybrid materials

21 January 2018

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Solid-phase ATRP synthesis of peptide-polymer hybrids

21 January 2018

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Synthesis of uniform protein-polymer conjugates

21 January 2018

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In situ preparation of protein-"smart" polymer conjugates with retention of bioactivity.

21 January 2018

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Well-defined protein-polymer conjugates via in situ RAFT polymerization

21 January 2018

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In situ formation of protein-polymer conjugates through reversible addition fragmentation chain transfer polymerization.

21 January 2018

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Streptavidin as a macroinitiator for polymerization: in situ protein-polymer conjugate formation

21 January 2018

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Block copolymers with amino acid sequences: Molecular chimeras of polypeptides and synthetic polymers

21 January 2018

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21 January 2018

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Synthesis of nearly monodisperse polystyrene-polypeptide block copolymers via polymerisation of N-carboxyanhydrides.

21 January 2018

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Facile synthesis of block copolypeptides of defined architecture

21 January 2018

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Inhibition of cell adhesion to fibronectin by oligopeptide-substituted polynorbornenes

21 January 2018

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beta -Helical polymers from isocyanopeptides

21 January 2018

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Beta-sheet side chain polymers synthesized by atom-transfer radical polymerization

21 January 2018

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Biological-synthetic hybrid block copolymers: Combining the best from two worlds

21 January 2018

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α-Functional glycopolymers: New materials for (poly)peptide conjugation

21 January 2018

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A Versatile Grafting-to Approach for the Bioconjugation of Polymers to Collagen-like Peptides Using an Activated Ester Chain Transfer Agent

21 January 2018

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Temperature Control of Biotin Binding and Release with A Streptavidin-Poly(N-isopropylacrylamide) Site-Specific Conjugate

21 January 2018

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Site-Specific Conjugation of a Temperature-Sensitive Polymer to a Genetically Engineered Protein

21 January 2018

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Problems and Possibilities of the Free-Radical Addition of Thiols to Unsaturated Compounds

21 January 2018

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Combining ATRP and “Click” Chemistry: a Promising Platform toward Functional Biocompatible Polymers and Polymer Bioconjugates

21 January 2018

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A Versatile Synthetic Approach to Polypeptide Based Rod−Coil Block Copolymers by Click Chemistry

21 January 2018

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Responsive Polymer‐Protein Bioconjugates Prepared by RAFT Polymerization and Copper‐Catalyzed Azide‐Alkyne Click Chemistry

21 January 2018

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Synthesis of Functionalized NMP Initiators for Click Chemistry: A Versatile Method for the Preparation of Functionalized Polymers and Block Copolymers

21 January 2018

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Highly Efficient “Click” Functionalization of Poly(3-azidopropyl methacrylate) Prepared by ATRP

21 January 2018

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Aminooxy End-Functionalized Polymers Synthesized by ATRP for Chemoselective Conjugation to Proteins

21 January 2018

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Direct Synthesis of Biotinylated Stimuli-Responsive Polymer and Diblock Copolymer by RAFT Polymerization Using Biotinylated Trithiocarbonate as RAFT Agent

21 January 2018

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Sequence-Defined Polypeptide−Polymer Conjugates Utilizing Reversible Addition Fragmentation Transfer Radical Polymerization

21 January 2018

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Easy Access to Bioactive Peptide−Polymer Conjugates via RAFT

21 January 2018

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Reversible switching of substrate activity of poly-N-isopropylacrylamide peptide conjugates

21 January 2018

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Surface-Initiated ATRP ofN-Isopropylacrylamide from Initiator-Modified Self-Assembled Peptide Nanotubes

21 January 2018

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Functionalized Micellar Assemblies Prepared via Block Copolymers Synthesized by Living Free Radical Polymerization upon Peptide-Loaded Resins

21 January 2018

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Fluorescently tagged polymer bioconjugates from protein derived macroinitiators

21 January 2018

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Vesicles and polymerized vesicles from thiophene-containing rod-coil block copolymers

21 January 2018

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Stimulus Responsive Behavior of Elastin-Based Side Chain Polymers

21 January 2018

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Elastin-Based Side-Chain Polymers: Improved Synthesis via RAFT and Stimulus Responsive Behavior

21 January 2018

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Site-Specific Protein Immobilization by Staudinger Ligation

21 January 2018

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General Method for Site-Specific Protein Immobilization by Staudinger Ligation

21 January 2018

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Control of protein–ligand recognition using a stimuli-responsive polymer

21 January 2018

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Peptide-polymer bioconjugates: hybrid block copolymers generated via living radical polymerizations from resin-supported peptides

21 January 2018

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Giant Amphiphiles by Cofactor Reconstitution

21 January 2018

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4 June 2024

https://opencitations.net/index/api/v1/citations/10.1002/1521-3773(20021115)41:22%3C4239::AID-ANIE4239%3E3.0.CO;2-E

Synthesis and characterization of polyisocyanides derived from alanine and glycine dipeptides

1 reference

4 June 2024

https://opencitations.net/index/api/v1/citations/10.1002/POLA.10083

Lipase polystyrene giant amphiphiles

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4 June 2024

https://opencitations.net/index/api/v1/citations/10.1021/JA017809B

Aggregation Behavior of Giant Amphiphiles Prepared by Cofactor Reconstitution

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4 June 2024

https://opencitations.net/index/api/v1/citations/10.1002/CHEM.200600089

Protein-Polymer Hybrid Amphiphiles This research was supported by the Netherlands Foundation for Chemical Research (CW-NWO), the EC TMR Sisitomas and ESF Smarton programs, and the Ministerio de Educación y Cultura (Spain). The authors thank H. P. M.

1 reference

4 June 2024

https://opencitations.net/index/api/v1/citations/10.1002/1521-3773(20011217)40:24%3C4732::AID-ANIE4732%3E3.0.CO;2-P

Solid phase synthesis of biohybrid block copolymers

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4 June 2024

https://opencitations.net/index/api/v1/citations/10.1039/B413973A

Self-Assembled Architectures from Biohybrid Triblock Copolymers

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4 June 2024

https://opencitations.net/index/api/v1/citations/10.1021/JA066790F

A Block Copolymer for Functionalisation of Polymersome Surfaces

1 reference

4 June 2024

https://opencitations.net/index/api/v1/citations/10.1002/MARC.200700765

Identifiers

DOI

10.1039/B807871H

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21 August 2017

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