(Q37660895)

21 August 2017

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title

Regulation of cell signalling by uPAR. (English)

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21 August 2017

Harvey W Smith

1

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PubMed ID

20027185

21 August 2017

Chris J Marshall

series ordinal

2

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21 August 2017

1 January 2010

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Nature Reviews Molecular Cell Biology

21 August 2017

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21 August 2017

11

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21 August 2017

1

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21 August 2017

23-36

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https://scigraph.springernature.com/pub.10.1038/nrm2821

21 August 2017

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cites work

Purification of zymogen to plasminogen activator from human glioblastoma cells by affinity chromatography with monoclonal antibody.

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Serpins and other covalent protease inhibitors

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Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation

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The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes

31 March 2020

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Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin

31 March 2020

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Inhibition of FAK signaling activated by urokinase receptor induces dormancy in human carcinoma cells in vivo

31 March 2020

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ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility

31 March 2020

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EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma

31 March 2020

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Rac mediates cytoskeletal rearrangements and increased cell motility induced by urokinase-type plasminogen activator receptor binding to vitronectin

31 March 2020

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Urokinase receptor is associated with the components of the JAK1/STAT1 signaling pathway and leads to activation of this pathway upon receptor clustering in the human kidney epithelial tumor cell line TCL-598

31 March 2020

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uPAR induces epithelial-mesenchymal transition in hypoxic breast cancer cells

31 March 2020

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Domain 2 of the urokinase receptor contains an integrin-interacting epitope with intrinsic signaling activity: generation of a new integrin inhibitor

31 March 2020

1 reference

An autocrine role for urokinase in phorbol ester-mediated differentiation of myeloid cell lines

31 March 2020

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uPAR-induced cell adhesion and migration: vitronectin provides the key

31 March 2020

1 reference

uPAR promotes formation of the p130Cas-Crk complex to activate Rac through DOCK180.

31 March 2020

1 reference

Regulation of integrin function by the urokinase receptor

31 March 2020

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A region in urokinase plasminogen receptor domain III controlling a functional association with alpha5beta1 integrin and tumor growth

31 March 2020

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Distinct ligand binding sites in integrin α3β1 regulate matrix adhesion and cell–cell contact

31 March 2020

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CD87 (urokinase-type plasminogen activator receptor), function and pathology in hematological disorders: a review

31 March 2020

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The urokinase receptor and its structural homologue C4.4A in human cancer: expression, prognosis and pharmacological inhibition

31 March 2020

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Intact and cleaved uPAR forms: diagnostic and prognostic value in cancer

31 March 2020

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Urokinase plasminogen activator receptor choreographs multiple ligand interactions: implications for tumor progression and therapy

31 March 2020

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Evolving role of uPA/uPAR system in human cancers

31 March 2020

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Plasminogen activation and cancer

31 March 2020

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The plasminogen activation system in inflammation.

31 March 2020

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Structure and function of the plasminogen/plasmin system

31 March 2020

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Urokinase and its receptors in chronic kidney disease.

31 March 2020

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uPAR: a versatile signalling orchestrator

31 March 2020

1 reference

Structure-function relationships in the receptor for urokinase-type plasminogen activator. Comparison to other members of the Ly-6 family and snake venom alpha-neurotoxins

31 March 2020

1 reference

Structure and ligand interactions of the urokinase receptor (uPAR).

31 March 2020

1 reference

Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes

31 March 2020

1 reference

Structure of human urokinase plasminogen activator in complex with its receptor

31 March 2020

1 reference

Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide

31 March 2020

1 reference

Mapping of the vitronectin-binding site on the urokinase receptor: involvement of a coherent receptor interface consisting of residues from both domain I and the flanking interdomain linker region

31 March 2020

1 reference

Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release?

31 March 2020

1 reference

Urokinase regulates vitronectin binding by controlling urokinase receptor oligomerization

31 March 2020

1 reference

Dimerization controls the lipid raft partitioning of uPAR/CD87 and regulates its biological functions

31 March 2020

1 reference

Monomer dimer dynamics and distribution of GPI-anchored uPAR are determined by cell surface protein assemblies

31 March 2020

1 reference

Glycosylation profile of a recombinant urokinase-type plasminogen activator receptor expressed in Chinese hamster ovary cells

31 March 2020

1 reference

Characterization of low-glycosylated forms of soluble human urokinase receptor expressed in Drosophila Schneider 2 cells after deletion of glycosylation-sites.

31 March 2020

1 reference

Identification and characterization of the murine cell surface receptor for the urokinase-type plasminogen activator

31 March 2020

1 reference

Cellular glycosylphosphatidylinositol-specific phospholipase D regulates urokinase receptor shedding and cell surface expression

31 March 2020

1 reference

Shedding and cleavage of the urokinase receptor (uPAR): identification and characterisation of uPAR fragments in vitro and in vivo

31 March 2020

1 reference

Modification of kidney barrier function by the urokinase receptor.

31 March 2020

1 reference

Cell-surface acceleration of urokinase-catalyzed receptor cleavage

31 March 2020

1 reference

The intact urokinase receptor is required for efficient vitronectin binding: receptor cleavage prevents ligand interaction

31 March 2020

1 reference

The cleavage of the urokinase receptor regulates its multiple functions

31 March 2020

1 reference

Mannose 6-phosphate/insulin-like growth factor 2 receptor limits cell invasion by controlling alphaVbeta3 integrin expression and proteolytic processing of urokinase-type plasminogen activator receptor.

31 March 2020

1 reference

Vascular endothelial growth factor receptor-2-induced initial endothelial cell migration depends on the presence of the urokinase receptor

31 March 2020

1 reference

Matrix metalloproteinase 12-dependent cleavage of urokinase receptor in systemic sclerosis microvascular endothelial cells results in impaired angiogenesis

31 March 2020

1 reference

The fibrinolytic receptor for urokinase activates the G protein-coupled chemotactic receptor FPRL1/LXA4R.

31 March 2020

1 reference

Urokinase induces basophil chemotaxis through a urokinase receptor epitope that is an endogenous ligand for formyl peptide receptor-like 1 and -like 2.

31 March 2020

1 reference

An uncleavable uPAR mutant allows dissection of signaling pathways in uPA-dependent cell migration.

31 March 2020

1 reference

alpha-2 Macroglobulin receptor/Ldl receptor-related protein(Lrp)-dependent internalization of the urokinase receptor

31 March 2020

1 reference

Direct binding of occupied urokinase receptor (uPAR) to LDL receptor-related protein is required for endocytosis of uPAR and regulation of cell surface urokinase activity

31 March 2020

1 reference

Recycling of the urokinase receptor upon internalization of the uPA:serpin complexes

31 March 2020

1 reference

A urokinase receptor-associated protein with specific collagen binding properties

31 March 2020

1 reference

GPI-anchored uPAR requires Endo180 for rapid directional sensing during chemotaxis.

31 March 2020

1 reference

Clathrin and LRP-1-independent constitutive endocytosis and recycling of uPAR.

31 March 2020

1 reference

The C-type lectin receptor Endo180 displays internalization and recycling properties distinct from other members of the mannose receptor family

31 March 2020

1 reference

Regulation of Rac1 activation by the low density lipoprotein receptor-related protein

31 March 2020

1 reference

Plasminogen activator inhibitor-1 regulates cell adhesion by binding to the somatomedin B domain of vitronectin

31 March 2020

1 reference

The murine receptor for urokinase-type plasminogen activator is primarily expressed in tissues actively undergoing remodeling

31 March 2020

1 reference

Localization and significance of urokinase plasminogen activator and its receptor in placental tissue from intrauterine, ectopic and molar pregnancies.

31 March 2020

1 reference

Urokinase plasminogen activator (uPA) and its receptor (uPAR) in gestational tissues; Measurements and clinical implications.

31 March 2020

1 reference

The receptor for urokinase-type plasminogen activator is expressed by keratinocytes at the leading edge during re-epithelialization of mouse skin wounds

31 March 2020

1 reference

Lesion-associated accumulation of uPAR/CD87- expressing infiltrating granulocytes, activated microglial cells/macrophages and upregulation by endothelial cells following TBI and FCI in humans.

31 March 2020

1 reference

Expression of the receptor for urokinase-type plasminogen activator in normal and neoplastic blood cells and hematopoietic tissue

31 March 2020

1 reference

Urokinase receptor (CD87) regulates leukocyte recruitment via beta 2 integrins in vivo.

31 March 2020

1 reference

Antigen-driven lymphocyte recruitment to the lung is diminished in the absence of urokinase-type plasminogen activator (uPA) receptor, but is independent of uPA.

31 March 2020

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Urokinase receptor-deficient mice have impaired neutrophil recruitment in response to pulmonary Pseudomonas aeruginosa infection

31 March 2020

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Urokinase receptor is necessary for adequate host defense against pneumococcal pneumonia.

31 March 2020

1 reference

Urokinase-type plasminogen activator receptor (uPAR) augments brain damage in a murine model of ischemic stroke

31 March 2020

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The absence of uPAR is associated with the progression of dermal fibrosis

31 March 2020

1 reference

Urokinase receptor deficiency accelerates renal fibrosis in obstructive nephropathy.

31 March 2020

1 reference

Urokinase receptor modulates cellular and angiogenic responses in obstructive nephropathy.

31 March 2020

1 reference

Immunohistochemical expression of uPA, uPAR, and PAI-1 in breast carcinoma. Fibroblastic expression has strong associations with tumor pathology

31 March 2020

1 reference

Immunohistochemical detection of the receptor for urokinase plasminogen activator in human colon cancer

31 March 2020

1 reference

Soluble urokinase-type plasminogen activator receptor inhibits cancer cell growth and invasion by direct urokinase-independent effects on cell signaling

31 March 2020

1 reference

Urokinase-type plasminogen activator receptor (CD87) is a ligand for integrins and mediates cell-cell interaction.

31 March 2020

1 reference

Recombinant soluble urokinase receptor as a scavenger for urokinase-type plasminogen activator (uPA). Inhibition of proliferation and invasion of human ovarian cancer cells

31 March 2020

1 reference

Reduction of breast carcinoma tumor growth and lung colonization by overexpression of the soluble urokinase-type plasminogen activator receptor (CD87).

31 March 2020

1 reference

Identification of SLURP-1 as an epidermal neuromodulator explains the clinical phenotype of Mal de Meleda

31 March 2020

1 reference

PATE gene clusters code for multiple, secreted TFP/Ly-6/uPAR proteins that are expressed in reproductive and neuron-rich tissues and possess neuromodulatory activity

31 March 2020

1 reference

Cancer-testis antigen lymphocyte antigen 6 complex locus K is a serologic biomarker and a therapeutic target for lung and esophageal carcinomas

31 March 2020

1 reference

Metastasis-associated C4.4A, a GPI-anchored protein cleaved by ADAM10 and ADAM17

31 March 2020

1 reference

The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website

31 March 2020

1 reference

Methylation of expanded CCG triplet repeat DNA from fragile X syndrome patients enhances nucleosome exclusion

31 March 2020

1 reference

NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha

31 March 2020

1 reference

Identification of a novel nuclear factor-kappaB sequence involved in expression of urokinase-type plasminogen activator receptor

31 March 2020

1 reference

Target genes of beta-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas

31 March 2020

1 reference

Identification of Tcf-4 as a transcriptional target of p53 signalling

31 March 2020

1 reference

Combination Analysis of Activator Protein-1 Family Members, Sp1 and an Activator Protein-2 -Related Factor Binding to Different Regions of the Urokinase Receptor Gene in Resected Colorectal Cancers

31 March 2020

1 reference

Analysis of specific transcriptional regulators as early predictors of independent prognostic relevance in resected colorectal cancer

31 March 2020

1 reference

Modulation of the receptor for urokinase-type plasminogen activator in macrophage-like U937 cells by inflammatory mediators

31 March 2020

1 reference

Regulation of urokinase receptor mRNA stability by hnRNP C in lung epithelial cells

31 March 2020

1 reference

Stabilization of Urokinase and Urokinase Receptor mRNAs by HuR Is Linked to Its Cytoplasmic Accumulation Induced by Activated Mitogen-Activated Protein Kinase-Activated Protein Kinase 2

31 March 2020

1 reference

Regulation of urokinase receptor expression by p53: novel role in stabilization of uPAR mRNA.

31 March 2020

1 reference

Overexpression of the embryonic-lethal abnormal vision-like protein HuR in ovarian carcinoma is a prognostic factor and is associated with increased cyclooxygenase 2 expression

31 March 2020

1 reference

Expression of the ELAV-like protein HuR is associated with higher tumor grade and increased cyclooxygenase-2 expression in human breast carcinoma

31 March 2020

1 reference

p53 in health and disease

31 March 2020

1 reference

Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas

31 March 2020

1 reference

Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor

31 March 2020

1 reference

Urokinase-induced signaling in human vascular smooth muscle cells is mediated by PDGFR-beta

31 March 2020

1 reference

A role for caveolin and the urokinase receptor in integrin-mediated adhesion and signaling

31 March 2020

1 reference

Regulation of urokinase receptor proteolytic function by the tetraspanin CD82.

31 March 2020

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Distribution and lateral mobility of the urokinase-receptor complex at the cell surface.

31 March 2020

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Urokinase receptors promote beta1 integrin function through interactions with integrin alpha3beta1.

31 March 2020

1 reference

Urokinase plasminogen activator receptor, beta 2-integrins, and Src-kinases within a single receptor complex of human monocytes

31 March 2020

1 reference

Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling

31 March 2020

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Regulation of alpha5beta1 integrin conformation and function by urokinase receptor binding.

31 March 2020

1 reference

Regulation of urokinase receptor function and pericellular proteolysis by the integrin alpha(5)beta(1).

31 March 2020

1 reference

Identification of a urokinase receptor-integrin interaction site. Promiscuous regulator of integrin function

31 March 2020

1 reference

Signaling through urokinase and urokinase receptor in lung cancer cells requires interactions with beta1 integrins

31 March 2020

1 reference

Function of the lectin domain of Mac-1/complement receptor type 3 (CD11b/CD18) in regulating neutrophil adhesion

31 March 2020

1 reference

The urokinase receptor (CD87) facilitates CD11b/CD18-mediated adhesion of human monocytes

31 March 2020

1 reference

The urokinase receptor is required for human monocyte chemotaxis in vitro

31 March 2020

1 reference

Function of the urokinase receptor (CD87) in neutrophil chemotaxis.

31 March 2020

1 reference

Cancer-related inflammation

31 March 2020

1 reference

The Receptor for Urokinase-type Plasminogen Activator Regulates Fibronectin Matrix Assembly in Human Skin Fibroblasts

31 March 2020

1 reference

The role of integrin binding sites in fibronectin matrix assembly in vivo

31 March 2020

1 reference

Urokinase-type plasminogen activator receptor regulates a novel pathway of fibronectin matrix assembly requiring Src-dependent transactivation of epidermal growth factor receptor

31 March 2020

1 reference

Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo.

31 March 2020

1 reference

Functional relevance of urinary-type plasminogen activator receptor-alpha3beta1 integrin association in proteinase regulatory pathways

31 March 2020

1 reference

Urokinase receptors are required for alpha 5 beta 1 integrin-mediated signaling in tumor cells

31 March 2020

1 reference

Urokinase receptor primes cells to proliferate in response to epidermal growth factor

31 March 2020

1 reference

Epidermal growth factor receptor-dependent and -independent cell-signaling pathways originating from the urokinase receptor

31 March 2020

1 reference

Cetuximab attenuates metastasis and u-PAR expression in non-small cell lung cancer: u-PAR and E-cadherin are novel biomarkers of cetuximab sensitivity.

31 March 2020

1 reference

uPAR-deficient mouse keratinocytes fail to produce EGFR-dependent laminin-5, affecting migration in vivo and in vitro

31 March 2020

1 reference

Comparative distribution of fibronectin and vitronectin in human breast and colon carcinomas. An immunofluorescence study

31 March 2020

1 reference

Glioblastoma expression of vitronectin and the alpha v beta 3 integrin. Adhesion mechanism for transformed glial cells

31 March 2020

1 reference

Induction of beta3-integrin gene expression by sustained activation of the Ras-regulated Raf-MEK-extracellular signal-regulated kinase signaling pathway

31 March 2020

1 reference

Hypoxia-inducible factor regulates alphavbeta3 integrin cell surface expression

31 March 2020

1 reference

Protein complexes regulating Arp2/3-mediated actin assembly.

31 March 2020

1 reference

Mechanisms of cancer cell invasion

31 March 2020

1 reference

Linking integrin conformation to function

31 March 2020

1 reference

Urokinase-type plasminogen activator receptor induces conformational changes in the integrin alphaMbeta2 headpiece and reorientation of its transmembrane domains

31 March 2020

1 reference

A composite role of vitronectin and urokinase in the modulation of cell morphology upon expression of the urokinase receptor

31 March 2020

1 reference

Vitronectin and its receptors

31 March 2020

1 reference

Electron crystallography of proteins in membranes

31 March 2020

1 reference

Induction of cell migration by pro-urokinase binding to its receptor: possible mechanism for signal transduction in human epithelial cells

31 March 2020

1 reference

Involvement of a mitogen-activated protein kinase signaling pathway in the regulation of urokinase promoter activity by c-Ha-ras.

31 March 2020

1 reference

Urokinase-type plasminogen activator stimulates the Ras/Extracellular signal-regulated kinase (ERK) signaling pathway and MCF-7 cell migration by a mechanism that requires focal adhesion kinase, Src, and Shc. Rapid dissociation of GRB2/Sps-Shc compl

31 March 2020

1 reference

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

31 March 2020

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Src kinase activation by direct interaction with the integrin β cytoplasmic domain

31 March 2020

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Downstream targets of urokinase-type plasminogen-activator-mediated signal transduction

31 March 2020

1 reference

Myosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective manner

31 March 2020

1 reference

Nudel binds Cdc42GAP to modulate Cdc42 activity at the leading edge of migrating cells

31 March 2020

1 reference

FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST

31 March 2020

1 reference

Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis

31 March 2020

1 reference

Metastasis of transgenic breast cancer in plasminogen activator inhibitor-1 gene-deficient mice

31 March 2020

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Reduced metastasis of transgenic mammary cancer in urokinase-deficient mice

31 March 2020

1 reference

Reduced metastasis of Polyoma virus middle T antigen-induced mammary cancer in plasminogen-deficient mice

31 March 2020

1 reference

Tumor and vascular targeting of a novel oncolytic measles virus retargeted against the urokinase receptor

31 March 2020

1 reference

Imaging of urokinase-type plasminogen activator receptor expression using a 64Cu-labeled linear peptide antagonist by microPET.

31 March 2020

1 reference

Requirement of an upstream AP-1 motif for the constitutive and phorbol ester-inducible expression of the urokinase-type plasminogen activator receptor gene

31 March 2020

1 reference

12 December 2020

Differential effects of fibroblast growth factors on expression of genes of the plasminogen activator and insulin-like growth factor systems by human breast fibroblasts

1 reference

12 December 2020

Metalloproteases cleave the urokinase-type plasminogen activator receptor in the D1-D2 linker region and expose epitopes not present in the intact soluble receptor

1 reference

12 December 2020

LY-6K gene: a novel molecular marker for human breast cancer

1 reference

12 December 2020

Urokinase receptor interacts with alpha(v)beta5 vitronectin receptor, promoting urokinase-dependent cell migration in breast cancer

1 reference

12 December 2020

Extracellular signal-regulated kinase functions in the urokinase receptor-dependent pathway by which neutralization of low density lipoprotein receptor-related protein promotes fibrosarcoma cell migration and matrigel invasion

1 reference

12 December 2020

Membrane-anchored uPAR regulates the proliferation, marrow pool size, engraftment, and mobilization of mouse hematopoietic stem/progenitor cells.

1 reference

12 December 2020

Plasminogen activation by receptor-bound urokinase. A kinetic study with both cell-associated and isolated receptor

1 reference

12 December 2020

Identification of the urokinase receptor as an adhesion receptor for vitronectin

1 reference

12 December 2020

Urokinase receptor. An activation antigen in human T lymphocytes

1 reference

12 December 2020

Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms

1 reference

12 December 2020

Purified alpha 2-macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex. Evidence that the alpha 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes

1 reference

12 December 2020

Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1.

1 reference

12 December 2020

Mac-1 (CD11b/CD18) and the urokinase receptor (CD87) form a functional unit on monocytic cells

1 reference

12 December 2020

Soluble receptor for urokinase plasminogen activator in both full-length and a cleaved form is present in high concentration in cystic fluid from ovarian cancer.

1 reference

12 December 2020

Urokinase-type plasminogen activator system and breast cancer (Review).

1 reference

12 December 2020

N-linked glycosylation of the ligand-binding domain of the human urokinase receptor contributes to the affinity for its ligand

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12 December 2020

Urokinase plasminogen activator cleaves its cell surface receptor releasing the ligand-binding domain

1 reference

12 December 2020

Characterization of the cellular binding site for the urokinase-type plasminogen activator

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12 December 2020

The human receptor for urokinase plasminogen activator. NH2-terminal amino acid sequence and glycosylation variants

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12 December 2020

Physical association of complement receptor type 3 and urokinase-type plasminogen activator receptor in neutrophil membranes

1 reference

12 December 2020

Urokinase-type plasminogen activator receptors associate with beta1 and beta3 integrins of fibrosarcoma cells: dependence on extracellular matrix components.

1 reference

12 December 2020

Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol

1 reference

12 December 2020

Electron microscopy of integrins

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12 December 2020

Identifiers

DOI

10.1038/NRM2821

1 reference

21 August 2017

1 reference

PubMed ID

20027185