(Q37668786)

English

Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase

scientific article published on 06 January 2014

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

21 August 2017

Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase (English)

1 reference

Europe PubMed Central

21 August 2017

object named as

Adam Yasgar

3

0 references

David A Taylor-Fishwick

object named as

David A Taylor-Fishwick

15

0 references

object named as

Ajit Jadhav

16

0 references

17

object named as

Anton Simeonov

1 reference

Europe PubMed Central

21 August 2017

8

object named as

Steve Perry

1 reference

Europe PubMed Central

21 August 2017

author name string

Diane K Luci

1

1 reference

Europe PubMed Central

21 August 2017

J Brian Jameson

2

1 reference

Europe PubMed Central

21 August 2017

Giovanni Diaz

4

1 reference

Europe PubMed Central

21 August 2017

Netra Joshi

5

1 reference

Europe PubMed Central

21 August 2017

Auric Kantz

6

1 reference

Europe PubMed Central

21 August 2017

Kate Markham

7

1 reference

Europe PubMed Central

21 August 2017

Norine Kuhn

9

1 reference

Europe PubMed Central

21 August 2017

Jennifer Yeung

10

1 reference

Europe PubMed Central

21 August 2017

Edward H Kerns

11

1 reference

Europe PubMed Central

21 August 2017

Lena Schultz

12

1 reference

Europe PubMed Central

21 August 2017

Michael Holinstat

13

1 reference

Europe PubMed Central

21 August 2017

Jerry L Nadler

14

1 reference

Europe PubMed Central

21 August 2017

Theodore R Holman

18

1 reference

Europe PubMed Central

21 August 2017

David J Maloney

19

1 reference

Europe PubMed Central

21 August 2017

language of work or name

0 references

publication date

6 January 2014

1 reference

Europe PubMed Central

21 August 2017

Journal of Medicinal Chemistry

1 reference

Europe PubMed Central

21 August 2017

57

1 reference

Europe PubMed Central

21 August 2017

2

1 reference

Europe PubMed Central

21 August 2017

495-506

1 reference

Europe PubMed Central

21 August 2017

Interaction between cytokines and inflammatory cells in islet dysfunction, insulin resistance and vascular disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

23 August 2017

Pseudoperoxidase investigations of hydroperoxides and inhibitors with human lipoxygenases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

23 August 2017

Investigations of human platelet-type 12-lipoxygenase: role of lipoxygenase products in platelet activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

23 August 2017

Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

23 August 2017

Resolvins and protectins in inflammation resolution.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

23 August 2017

Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

23 August 2017

Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

23 August 2017

12-Lipoxygenase Products Reduce Insulin Secretion and {beta}-Cell Viability in Human Islets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

23 August 2017

Phospholipid-esterified eicosanoids are generated in agonist-activated human platelets and enhance tissue factor-dependent thrombin generation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

23 August 2017

Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

23 August 2017

7-fluoroindazoles as potent and selective inhibitors of factor Xa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

23 August 2017

Novel lipoxygenase inhibitors as neuroprotective reagents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

23 August 2017

Nonobese diabetic (NOD) mice congenic for a targeted deletion of 12/15-lipoxygenase are protected from autoimmune diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

23 August 2017

Structure-activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

23 August 2017

Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

23 August 2017

Zileuton: clinical implications of 5-Lipoxygenase inhibition in severe airway disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

23 August 2017

Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

23 August 2017

Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

23 August 2017

Novel human lipoxygenase inhibitors discovered using virtual screening with homology models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

23 August 2017

New aspects on the role of lipoxygenases in cancer progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

23 August 2017

Activation of 12-lipoxygenase in proinflammatory cytokine-mediated beta cell toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

23 August 2017

Lessons learned from marketed and investigational prodrugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

23 August 2017

12/15-lipoxygenase is increased in Alzheimer's disease: possible involvement in brain oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

23 August 2017

Optimization of alkylidene hydrazide based human glucagon receptor antagonists. Discovery of the highly potent and orally available 3-cyano-4-hydroxybenzoic acid [1-(2,3,5,6-tetramethylbenzyl)-1H-indol-4-ylmethylene]hydrazide.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

23 August 2017

Eicosanoid regulation of angiogenesis: role of endothelial arachidonate 12-lipoxygenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

23 August 2017

Synthesis and biological activities of novel antiallergic agents with 5-lipoxygenase inhibiting action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

23 August 2017

Lipoxygenases: occurrence, functions, catalysis, and acquisition of substrate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

23 August 2017

Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

23 August 2017

Resistance to type 1 diabetes induction in 12-lipoxygenase knockout mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

23 August 2017

Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

23 August 2017

Platelet-type 12-lipoxygenase in a human prostate carcinoma stimulates angiogenesis and tumor growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

23 August 2017

Purification and characterization of recombinant histidine-tagged human platelet 12-lipoxygenase expressed in a baculovirus/insect cell system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

23 August 2017

Mammalian lipoxygenases: molecular structures and functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

23 August 2017

A review of possible roles of the platelet 12-lipoxygenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

14 September 2017

Increased 12-lipoxygenase expression in breast cancer tissues and cells. Regulation by epidermal growth factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

28 September 2017

Murine epidermal lipoxygenase (Aloxe) encodes a 12-lipoxygenase isoform

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

28 September 2017

Changes in lipoxygenase activities in human erythroleukemia (HEL) cells during diosgenin-induced differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

28 September 2017

New insights from spectroscopy into the structure/function relationships of lipoxygenases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

25 June 2018

Inhibition of platelet and neutrophil phospholipase A2 by hydroxyeicosatetraenoic acids (HETES). A novel pharmacological mechanism for regulating free fatty acid release

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

25 June 2018

12-lipoxygenase activity plays an important role in PAR4 and GPVI-mediated platelet reactivity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

1 September 2018

Baicalein and 12/15-lipoxygenase in the ischemic brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

1 September 2018

Redox inactivation of human 15-lipoxygenase by marine-derived meroditerpenes and synthetic chromanes: archetypes for a unique class of selective and recyclable inhibitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

1 September 2018

Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

1 September 2018

Inhibition of arachidonate 5-lipoxygenase triggers prostate cancer cell death through rapid activation of c-Jun N-terminal kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

1 September 2018

Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

1 September 2018

Structure-activity relationship studies of nordihydroguaiaretic acid inhibitors toward soybean, 12-human, and 15-human lipoxygenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

1 September 2018

Synergistic effects of new chemopreventive agents and conventional cytotoxic agents against human lung cancer cell lines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

1 September 2018

Defining the arachidonic acid binding site of human 15-lipoxygenase. Molecular modeling and mutagenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

1 September 2018

Platelet lipoxygenase inhibitors attenuate thrombin- and thromboxane mimetic-induced intracellular calcium mobilization and platelet aggregation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3967794

1 September 2018

A Re(V)-catalyzed C-N bond-forming route to human lipoxygenase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/24393039

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The possible involvement of 15-lipoxygenase/leukocyte type 12-lipoxygenase in colorectal carcinogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24393039

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of 15-lipoxygenase in vascular endothelium accelerates early atherosclerosis in LDL receptor-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24393039

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitors of 15-lipoxygenase from orange peel

1 reference

https://pubmed.ncbi.nlm.nih.gov/24393039

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of arachidonate-induced platelet aggregation by the lipoxygenase product, 12-hydroperoxyeicosatetraenoic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/24393039

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of melanoma-cell motility by the lipoxygenase metabolite 12-(S)-HETE

1 reference

https://pubmed.ncbi.nlm.nih.gov/24393039

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Lipoxygenase Metabolite, 12-(S)-HETE, Stimulates Protein Kinase C-Mediated Release of Cathepsin B from Malignant Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24393039

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of lipoxygenase activity by bacterial hopanoids

1 reference

https://pubmed.ncbi.nlm.nih.gov/24393039

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of an acetyl-11-keto-beta-boswellic acid and arachidonate-binding regulatory site of 5-lipoxygenase using photoaffinity labeling

1 reference

https://pubmed.ncbi.nlm.nih.gov/24393039

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM4016476

1 reference

Europe PubMed Central

21 August 2017

1 reference

Europe PubMed Central

21 August 2017

1 reference

Europe PubMed Central

21 August 2017

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q37668786&oldid=2133589716"