(Q37679774)

21 August 2017

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title

A review of current large-scale mouse knockout efforts (English)

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21 August 2017

Chunmei Guan

1

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21 August 2017

Chao Ye

series ordinal

2

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21 August 2017

Xiaomei Yang

series ordinal

3

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21 August 2017

Jiangang Gao

series ordinal

4

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21 August 2017

publication date

1 February 2010

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21 August 2017

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21 August 2017

volume

48

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21 August 2017

issue

2

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21 August 2017

page(s)

73-85

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From glycomics to functional glycomics of sugar chains: Identification of target proteins with functional changes using gene targeting mice and knock down cells of FUT8 as examples

21 August 2017

cites work

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The Human Genome Project in retrospect

21 January 2018

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7 January 2021

Gene trap mutagenesis

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7 January 2021

Mutagenic insertion and chromosome engineering resource (MICER).

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7 January 2021

Regulatory effects of mammalian target of rapamycin-mediated signals in the generation of arsenic trioxide responses

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7 January 2021

Insertional mutagenesis in zebrafish

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7 January 2021

International Gene Trap Project: towards gene-driven saturation mutagenesis in mice

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7 January 2021

The knockout mouse project

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7 January 2021

Appearances can be deceiving: phenotypes of knockout mice.

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7 January 2021

Transposons reanimated in mice

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7 January 2021

Some facts and thoughts: p73 as a tumor suppressor gene in the network of tumor suppressors

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7 January 2021

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7 January 2021

From Mendel to the Human Genome Project: the implications for nurse education

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7 January 2021

Neuromuscular development in the absence of programmed cell death: phenotypic alteration of motoneurons and muscle

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7 January 2021

Altering the genome by homologous recombination

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7 January 2021

Generating mice with targeted mutations

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7 January 2021

Somatic integration of an oncogene-harboring Sleeping Beauty transposon models liver tumor development in the mouse

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7 January 2021

A recombineering based approach for high-throughput conditional knockout targeting vector construction

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7 January 2021

Draft mouse genome makes public debut.

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7 January 2021

A new partner for the international knockout mouse consortium

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7 January 2021

A Mouse for All Reasons

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7 January 2021

Recombineering: a powerful new tool for mouse functional genomics

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7 January 2021

Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice

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7 January 2021

Transposition and gene disruption in the male germline of the mouse

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7 January 2021

Protein function in the post-genomic era.

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7 January 2021

Establishment in culture of pluripotential cells from mouse embryos

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7 January 2021

Gene targeting using a promoterless gene trap vector ("targeted trapping") is an efficient method to mutate a large fraction of genes.

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7 January 2021

EUCOMM--the European conditional mouse mutagenesis program.

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7 January 2021

Targeting hearing genes in mice

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7 January 2021

In vivo functions of mitogen-activated protein kinases: conclusions from knock-in and knock-out mice

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7 January 2021

Current issues in mouse genome engineering

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7 January 2021

Trends in large-scale mouse mutagenesis: from genetics to functional genomics

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7 January 2021

Mouse embryonic stem cells and reporter constructs to detect developmentally regulated genes.

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7 January 2021

The role of the human genome project in disease prevention

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7 January 2021

A physical map of the mouse genome

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7 January 2021

Mouse genetics. A mouse for every gene

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7 January 2021

'Knock, and it shall be opened': knocking out and knocking in to reveal mechanisms of disease and novel therapies

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7 January 2021

Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.

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7 January 2021

Transgenic gene knock-outs: functional genomics and therapeutic target selection

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7 January 2021

TILLING. Traditional mutagenesis meets functional genomics.

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7 January 2021

Functional genomics in mice by tagged sequence mutagenesis

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7 January 2021

Getting nearer the mark

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7 January 2021

RET: a poly A-trap retrovirus vector for reversible disruption and expression monitoring of genes in living cells

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7 January 2021

The human genome project: what impact on basic research?

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7 January 2021

A transgene containing lacZ inserted into the dystonia locus is expressed in neural tube.

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7 January 2021

Advances in gene targeting methods

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7 January 2021

A highly efficient Escherichia coli-based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNA

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7 January 2021

Gene trap mutagenesis: a functional genomics approach towards reproductive research

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7 January 2021

A highly efficient recombineering-based method for generating conditional knockout mutations

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7 January 2021

Gene targeting in embryonic stem cells scores a knockout in Stockholm.

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7 January 2021

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

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7 January 2021

Genome sequencing. Public group completes draft of the mouse.

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7 January 2021

Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells

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7 January 2021

Expression profiling with arrays of randomly disrupted genes in mouse embryonic stem cells leads to in vivo functional analysis

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7 January 2021

Positive-negative selection gene targeting with the diphtheria toxin A-chain gene in mouse embryonic stem cells.

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7 January 2021

Efficient gene-specific expression of cre recombinase in the mouse embryo by targeted insertion of a novel IRES-Cre cassette into endogenous loci.

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7 January 2021

Reverse genetics in zebrafish by TILLING.

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7 January 2021

Gene targeting in embryonic stem cells: the new physiology and metabolism.

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7 January 2021

An efficient gene-trap method using poly A trap vectors and characterization of gene-trap events

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7 January 2021

Detection in situ of genomic regulatory elements in Drosophila

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7 January 2021

Mutation detection using a novel plant endonuclease

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7 January 2021

A novel view of the transcriptome revealed from gene trapping in mouse embryonic stem cells

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7 January 2021

The UniTrap resource: tools for the biologist enabling optimized use of gene trap clones.

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7 January 2021

Neurobiology of animal models of attention-deficit hyperactivity disorder

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7 January 2021

Efficient poly A trap approach allows the capture of genes specifically active in differentiated embryonic stem cells and in mouse embryos.

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7 January 2021

Generation of multipurpose alleles for the functional analysis of the mouse genome

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7 January 2021

Adopting the good reFLEXes when generating conditional alterations in the mouse genome

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7 January 2021

Genomewide production of multipurpose alleles for the functional analysis of the mouse genome

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7 January 2021

Enhanced gene trapping in mouse embryonic stem cells

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7 January 2021

Suppression of nonsense-mediated mRNA decay permits unbiased gene trapping in mouse embryonic stem cells

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7 January 2021

Capturing genes encoding membrane and secreted proteins important for mouse development

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7 January 2021

Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination

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7 January 2021

Gene-trap mutagenesis: past, present and beyond

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7 January 2021

BayGenomics: a resource of insertional mutations in mouse embryonic stem cells

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7 January 2021

PBmice: an integrated database system of piggyBac (PB) insertional mutations and their characterizations in mice

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7 January 2021

Use of the HPRT gene and the HAT selection technique in DNA-mediated transformation of mammalian cells: first steps toward developing hybridoma techniques and gene therapy

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7 January 2021

A gene trap approach to identify genes that control development

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7 January 2021

Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.

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7 January 2021

A reliable lacZ expression reporter cassette for multipurpose, knockout-first alleles

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7 January 2021

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

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7 January 2021

High-throughput engineering of the mouse genome coupled with high-resolution expression analysis

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7 January 2021

An allelic series of mutations in Smad2 and Smad4 identified in a genotype-based screen of N-ethyl-N- nitrosourea-mutagenized mouse embryonic stem cells

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7 January 2021

Aberrant sensory innervation of the olfactory bulb in neuropilin-2 mutant mice.

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7 January 2021

Genetic evidence for adenylyl cyclase 1 as a target for preventing neuronal excitotoxicity mediated by N-methyl-D-aspartate receptors.

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7 January 2021

c-Jun NH2-terminal kinase promotes apoptosis by down-regulating the transcriptional co-repressor CtBP.

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7 January 2021

A piggyBac transposon-based genome-wide library of insertionally mutated Blm-deficient murine ES cells

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7 January 2021

Origins of the Human Genome Project.

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7 January 2021

Toward simpler and faster genome-wide mutagenesis in mice

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7 January 2021

A stringent dual control system overseeing transcription and activity of the Cre recombinase for the liver-specific conditional gene knock-out mouse model

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7 January 2021

A novel negative selection for homologous recombinants using diphtheria toxin A fragment gene.

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7 January 2021

Somatic integration and long-term transgene expression in normal and haemophilic mice using a DNA transposon system

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7 January 2021

Thyroid hormone action at the cellular, genomic and target gene levels.

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7 January 2021

Engineering chromosomal rearrangements in mice

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7 January 2021

Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells

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7 January 2021

Wnk1 kinase deficiency lowers blood pressure in mice: A gene-trap screen to identify potential targets for therapeutic intervention

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7 January 2021

A system for rapid generation of coat color-tagged knockouts and defined chromosomal rearrangements in mice

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7 January 2021

Identifiers

DOI

10.1002/DVG.20594

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21 August 2017

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