(Q36706331)

15 August 2017

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title

In vivo functions of mitogen-activated protein kinases: conclusions from knock-in and knock-out mice (English)

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15 August 2017

3

Ugo Moens

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15 August 2017

2

Sergiy Kostenko

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15 August 2017

Nancy Gerits

1

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15 August 2017

publication date

12 January 2007

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15 August 2017

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15 August 2017

volume

16

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15 August 2017

issue

3

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15 August 2017

page(s)

281-314

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ERK1-/- mice exhibit Th1 cell polarization and increased susceptibility to experimental autoimmune encephalomyelitis.

15 August 2017

cites work

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS11248-006-9052-0

ERK1-deficient mice show normal T cell effector function and are highly susceptible to experimental autoimmune encephalomyelitis.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS11248-006-9052-0

The role of the Grb2-p38 MAPK signaling pathway in cardiac hypertrophy and fibrosis

21 January 2018

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Crossref

https://api.crossref.org/works/10.1007%2FS11248-006-9052-0

c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis

21 January 2018

1 reference

12 December 2020

Defective T Cell Differentiation in the Absence of Jnk1

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12 December 2020

MEKK1 is essential for cardiac hypertrophy and dysfunction induced by Gq.

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12 December 2020

Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH2-terminal kinase activation, and defects in AP-1 transcriptional activity

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12 December 2020

A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells

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12 December 2020

Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation

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12 December 2020

Knockout of ERK1 enhances cocaine-evoked immediate early gene expression and behavioral plasticity

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12 December 2020

Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2.

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12 December 2020

Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling

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12 December 2020

Novel p38 inhibitors with potent oral efficacy in several models of rheumatoid arthritis

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12 December 2020

Role of MAPKs in development and differentiation: lessons from knockout mice.

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12 December 2020

ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5.

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12 December 2020

The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions

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12 December 2020

MAPKAP kinases - MKs - two's company, three's a crowd

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12 December 2020

Targeted inhibition of p38 mitogen-activated protein kinase antagonizes cardiac injury and cell death following ischemia-reperfusion in vivo

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12 December 2020

Counting on mitogen-activated protein kinases--ERKs 3, 4, 5, 6, 7 and 8.

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12 December 2020

JNK is required for effector T-cell function but not for T-cell activation

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12 December 2020

p38alpha mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload.

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12 December 2020

Activation of apoptosis signal-regulating kinase 1 in injured artery and its critical role in neointimal hyperplasia

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12 December 2020

The essential role of MEKK3 in TNF-induced NF-kappaB activation

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12 December 2020

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain

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12 December 2020

ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions

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12 December 2020

The origins of protein phosphorylation

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12 December 2020

Regulatory mechanisms and functions of MAP kinase signaling pathways.

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12 December 2020

JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development.

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12 December 2020

Lung-targeted expression of the c-Raf-1 kinase in transgenic mice exposes a novel oncogenic character of the wild-type protein

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12 December 2020

The JNK pathway regulates the In vivo deletion of immature CD4(+)CD8(+) thymocytes

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12 December 2020

Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development

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12 December 2020

Regulation of intracellular signalling by the terminal membrane proteins of members of the Gammaherpesvirinae

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12 December 2020

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

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12 December 2020

Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice

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12 December 2020

Mekk3 is essential for early embryonic cardiovascular development

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12 December 2020

Renal abnormalities in mice caused by insufficiency of p38alpha

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12 December 2020

Essential role of p38 mitogen-activated protein kinase in contact hypersensitivity

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12 December 2020

Construction of a conditional allele of RSK-B/MSK2 in the mouse

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12 December 2020

Craf-1 protein kinase is essential for mouse development.

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12 December 2020

Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis

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12 December 2020

PAK3 mutation in nonsyndromic X-linked mental retardation

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12 December 2020

Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development

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12 December 2020

p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP

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12 December 2020

Recent advances in stress signaling in cancer

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12 December 2020

Essential role for ERK2 mitogen-activated protein kinase in placental development

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12 December 2020

Elimination of protein kinase MK5/PRAK activity by targeted homologous recombination

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12 December 2020

R-130823, a novel inhibitor of p38 MAPK, ameliorates hyperalgesia and swelling in arthritis models

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12 December 2020

Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption

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12 December 2020

Gene deletion of MK2 inhibits TNF-alpha and IL-6 and protects against cerulein-induced pancreatitis

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12 December 2020

Important Role of Apoptosis Signal-Regulating Kinase 1 in Ischemia-Induced Angiogenesis

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12 December 2020

Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway

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12 December 2020

Regulation of cellular functions by the ERK5 signalling pathway

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12 December 2020

Loss of mitogen-activated protein kinase kinase kinase 4 (MEKK4) results in enhanced apoptosis and defective neural tube development.

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12 December 2020

Expression of endogenous oncogenic V600EB-raf induces proliferation and developmental defects in mice and transformation of primary fibroblasts

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12 December 2020

MK2-/- gene knockout mouse hearts carry anti-apoptotic signal and are resistant to ischemia reperfusion injury.

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12 December 2020

Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta

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12 December 2020

Post-natal lethality and neurological and gastrointestinal defects in mice with targeted disruption of the A-Raf protein kinase gene.

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12 December 2020

Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene

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12 December 2020

TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis

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12 December 2020

The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy.

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12 December 2020

Ablation of MEKK4 kinase activity causes neurulation and skeletal patterning defects in the mouse embryo.

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12 December 2020

The IkappaB function of NF-kappaB2 p100 controls stimulated osteoclastogenesis

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12 December 2020

New multiple congenital anomalies/mental retardation syndrome with cardio-facio-cutaneous involvement--the CFC syndrome

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12 December 2020

Role of 14-3-3-mediated p38 mitogen-activated protein kinase inhibition in cardiac myocyte survival

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12 December 2020

Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades

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12 December 2020

Mitogen-activated protein kinases in apoptosis regulation

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12 December 2020

Ventilation-induced neutrophil infiltration depends on c-Jun N-terminal kinase

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12 December 2020

Activation of the Erk8 mitogen-activated protein (MAP) kinase by RET/PTC3, a constitutively active form of the RET proto-oncogene.

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12 December 2020

The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice

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12 December 2020

MEK kinase activity is not necessary for Raf-1 function

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12 December 2020

Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosis

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12 December 2020

Use of mitogenic cascade blockers for treatment of C-Raf induced lung adenoma in vivo: CI-1040 strongly reduces growth and improves lung structure

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12 December 2020

Ringing the alarm bells: signalling and apoptosis in influenza virus infected cells

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12 December 2020

Influenza-virus-induced signaling cascades: targets for antiviral therapy?

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12 December 2020

Role of MAP kinase-dependent apoptotic pathway in innate immune responses and viral infection

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12 December 2020

MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts

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12 December 2020

Mice lacking the ERK1 isoform of MAP kinase are unimpaired in emotional learning

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12 December 2020

MEK kinase 1 gene disruption alters cell migration and c-Jun NH2-terminal kinase regulation but does not cause a measurable defect in NF-kappa B activation

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12 December 2020

Role of p38alpha MAPK in cardiac apoptosis and remodeling after myocardial infarction

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12 December 2020

Defective lymphotoxin-beta receptor-induced NF-kappaB transcriptional activity in NIK-deficient mice.

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12 December 2020

Disruption of a single copy of the p38alpha MAP kinase gene leads to cardioprotection against ischemia-reperfusion.

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12 December 2020

Targeting the mitogen-activated protein kinase cascade to treat cancer

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12 December 2020

PAK4 Kinase Is Essential for Embryonic Viability and for Proper Neuronal Development

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12 December 2020

Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis

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12 December 2020

MAPKAP kinase 2-deficient mice are resistant to collagen-induced arthritis

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12 December 2020

Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2.

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12 December 2020

Mechanism of p38 MAP kinase activation in vivo.

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12 December 2020

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

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12 December 2020

Targeted disruption of the gene for the PAK5 kinase in mice

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12 December 2020

Essential function for the kinase TAK1 in innate and adaptive immune responses.

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12 December 2020

TAK1 is activated in the myocardium after pressure overload and is sufficient to provoke heart failure in transgenic mice.

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12 December 2020

Subversion mechanisms by which Leishmania parasites can escape the host immune response: a signaling point of view.

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12 December 2020

MEKK2 gene disruption causes loss of cytokine production in response to IgE and c-Kit ligand stimulation of ES cell-derived mast cells

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12 December 2020

A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure

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12 December 2020

Development of cataractous macrophthalmia in mice expressing an active MEK1 in the lens.

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12 December 2020

Disease-modifying activity of SB 242235, a selective inhibitor of p38 mitogen-activated protein kinase, in rat adjuvant-induced arthritis

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12 December 2020

GADD45beta/GADD45gamma and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNgamma production in T cells.

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12 December 2020

MEKK2 regulates the coordinate activation of ERK5 and JNK in response to FGF-2 in fibroblasts.

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12 December 2020

Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function

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12 December 2020

MEK kinase 1 activity is required for definitive erythropoiesis in the mouse fetal liver.

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12 December 2020

Transforming growth factor-beta-activated kinase 1 is essential for differentiation and the prevention of apoptosis in epidermis

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12 December 2020

MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity. Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease

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12 December 2020

Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy

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12 December 2020

Essential role of TAK1 in thymocyte development and activation.

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12 December 2020

Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis

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12 December 2020

Constitutive activation of MKK6 in chondrocytes of transgenic mice inhibits proliferation and delays endochondral bone formation

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12 December 2020

Essential functions of p21-activated kinase 1 in morphogenesis and differentiation of mammary glands

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12 December 2020

Components of a new human protein kinase signal transduction pathway

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12 December 2020

High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma

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12 December 2020

Midlatency auditory event-related potentials in mice: comparison to midlatency auditory ERPs in humans.

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12 December 2020

Cloning and characterization of PAK5, a novel member of mammalian p21-activated kinase-II subfamily that is predominantly expressed in brain

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12 December 2020

PAK1 hyperactivation is sufficient for mammary gland tumor formation

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12 December 2020

Raf-1 kinase is required for cardiac hypertrophy and cardiomyocyte survival in response to pressure overload

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12 December 2020

Lung-specific expression of active Raf kinase results in increased mortality of influenza A virus-infected mice

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12 December 2020

Generation and characterization of p38beta (MAPK11) gene-targeted mice.

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12 December 2020

Essential role of B-Raf in ERK activation during extraembryonic development

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12 December 2020

A-Raf and Raf-1 work together to influence transient ERK phosphorylation and Gl/S cell cycle progression

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12 December 2020

An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development

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12 December 2020

Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia

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12 December 2020

Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-kappa b-inducing kinase

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12 December 2020

Endothelial apoptosis in Braf-deficient mice

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12 December 2020

Signaling during pathogen infection

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12 December 2020

JNK1 but not JNK2 promotes the development of steatohepatitis in mice

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12 December 2020

SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis

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12 December 2020

Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome

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12 December 2020

NF-(kappa)B-inducing kinase controls lymphocyte and osteoclast activities in inflammatory arthritis

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12 December 2020

Scaffolding by ERK3 regulates MK5 in development

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12 December 2020

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

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12 December 2020

Targeted deletion of apoptosis signal-regulating kinase 1 attenuates left ventricular remodeling

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12 December 2020

Raf-1 is not required for megakaryocytopoiesis or TPO-induced ERK phosphorylation

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12 December 2020

Forebrain-specific knockout of B-raf kinase leads to deficits in hippocampal long-term potentiation, learning, and memory

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12 December 2020

Tumor necrosis factor-induced toxic liver injury results from JNK2-dependent activation of caspase-8 and the mitochondrial death pathway

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12 December 2020

Signal transduction by the JNK group of MAP kinases

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12 December 2020

Deficiency of a STE20/PAK family kinase LOK leads to the acceleration of LFA-1 clustering and cell adhesion of activated lymphocytes

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12 December 2020

Targeting the ERK signaling pathway in cancer therapy

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12 December 2020

Knockout of ERK5 causes multiple defects in placental and embryonic development

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12 December 2020

Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory

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12 December 2020

Abnormal long-lasting synaptic plasticity and cognition in mice lacking the mental retardation gene Pak3.

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12 December 2020

MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis

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12 December 2020

Primary Structure of BMK1: A New Mammalian MAP Kinase

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12 December 2020

Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation.

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12 December 2020

Apoptosis signal-regulating kinase 1 plays a pivotal role in angiotensin II-induced cardiac hypertrophy and remodeling.

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12 December 2020

Diet-dependent effects of the Drosophila Mnk1/Mnk2 homolog Lk6 on growth via eIF4E.

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12 December 2020

c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity

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12 December 2020

Ablation of MEK kinase 1 suppresses intimal hyperplasia by impairing smooth muscle cell migration and urokinase plasminogen activator expression in a mouse blood-flow cessation model

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12 December 2020

Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation

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12 December 2020

The essential role of MEKK3 signaling in angiotensin II-induced calcineurin/nuclear factor of activated T-cells activation

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12 December 2020

The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development

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12 December 2020

Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice.

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12 December 2020

Raf-1 regulates Rho signaling and cell migration

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12 December 2020

Extracellular signal-regulated kinase 7, a regulator of hormone-dependent estrogen receptor destruction

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12 December 2020

Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice

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12 December 2020

Disruption of Mekk2 in mice reveals an unexpected role for MEKK2 in modulating T-cell receptor signal transduction

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12 December 2020

Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions

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12 December 2020

Expression of activated MEK1 in differentiating epidermal cells is sufficient to generate hyperproliferative and inflammatory skin lesions

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12 December 2020

Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4.

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12 December 2020

Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes

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12 December 2020

Abnormal bone marrow stroma in mice deficient for nemo-like kinase, Nlk.

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12 December 2020

Targeted deletion of mek5 causes early embryonic death and defects in the extracellular signal-regulated kinase 5/myocyte enhancer factor 2 cell survival pathway

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12 December 2020

Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance

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12 December 2020

Mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 deficiency protects brain from ischemic injury in mice

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12 December 2020

The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis

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12 December 2020

JNK1 is required to preserve cardiac function in the early response to pressure overload

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12 December 2020

ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

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12 December 2020

Insulin-stimulated glucose uptake does not require p38 mitogen-activated protein kinase in adipose tissue or skeletal muscle

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12 December 2020

Adenovirus-induced extracellular signal-regulated kinase phosphorylation during the late phase of infection enhances viral protein levels and virus progeny

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12 December 2020

The many paths to p38 mitogen-activated protein kinase activation in the immune system

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12 December 2020

Inhibitors of signal transduction protein kinases as targets for cancer therapy

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12 December 2020

Insights into regulation of human Schwann cell proliferation by Erk1/2 via a MEK-independent and p56Lck-dependent pathway from leprosy bacilli

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12 December 2020

Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway

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12 December 2020

Mek2 is dispensable for mouse growth and development

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12 December 2020

Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis

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12 December 2020

Parsing molecular and behavioral effects of cocaine in mitogen- and stress-activated protein kinase-1-deficient mice.

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12 December 2020

10.1007/S11248-006-9052-0

Identifiers

DOI

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15 August 2017

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