(Q37689806)

22 August 2017

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title

Acute toxicity testing of chemicals-Opportunities to avoid redundant testing and use alternative approaches (English)

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22 August 2017

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Stuart Creton

1

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22 August 2017

Ian C Dewhurst

2

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22 August 2017

Lesley K Earl

3

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22 August 2017

Sean C Gehen

4

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22 August 2017

Robert L Guest

5

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22 August 2017

Jon A Hotchkiss

6

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22 August 2017

Ian Indans

7

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22 August 2017

Michael R Woolhiser

8

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22 August 2017

Richard Billington

9

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22 August 2017

language of work or name

English

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publication date

1 January 2010

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Critical Reviews in Toxicology

22 August 2017

published in

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22 August 2017

volume

40

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22 August 2017

issue

1

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22 August 2017

page(s)

50-83

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Successful prevalidation of the slug mucosal irritation test to assess the eye irritation potency of chemicals

22 August 2017

cites work

1 reference

https://api.crossref.org/works/10.3109%2F10408440903401511

Reactivity profiling: covalent modification of single nucleophile peptides for skin sensitization risk assessment.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903401511

A plasmacytoid dendritic cell (CD123+/CD11c-) based assay system to predict contact allergenicity of chemicals

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903401511

An experimental in vitro model for dynamic direct exposure of human cells to airborne contaminants.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903401511

A novel in vitro exposure technique for toxicity testing of selected volatile organic compounds.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903401511

Why modification of the LD50 test will not be enough

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903401511

Interlaboratory validation of 1% pluronic l92 surfactant as a suitable, aqueous vehicle for testing pesticide formulations using the murine local lymph node assay

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903401511

Determination of the intra- and interlaboratory reproducibility of the low volume eye test and its statistical relationship to the Draize eye test

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903401511

Alternative test methods in inhalation toxicology: challenges and opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903401511

Investigation of peptide reactivity of pro-hapten skin sensitizers using a peroxidase-peroxide oxidation system

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903401511

How do we compare dose to cells in vitro with dose to live animals and humans? Some experiences with inhaled substances.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903401511

Comparison of low-volume, Draize and in vitro eye irritation test data. I. Hydroalcoholic formulations

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903401511

A comparison of low volume, draize and in vitro eye irritation test data. II. Oil/water emulsions

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903401511

A comparison of low volume, Draize and in vitro eye irritation test data. III. Surfactant-based formulations

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903401511

Antioxidant effect of onion oil (Allium cepa. Linn) on the damages induced by nicotine in rats as compared to alpha-tocopherol

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903401511

Chemical regulators have overreached

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903401511

Alternative test models: ocular safety assays accepted

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903401511

A cell-based in vitro alternative to identify skin sensitizers by gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903401511

Tracheobronchial air-liquid interface cell culture: a model for innate mucosal defense of the upper airways?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903401511

Dendritic cells and skin sensitisation hazard assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903401511

ECVAM's ongoing activities in the area of acute oral toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903401511

Air-liquid interface culture of serially passaged human nasal epithelial cell monolayer for in vitro drug transport studies

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903401511

Air-liquid interface (ALI) culture of human bronchial epithelial cell monolayers as an in vitro model for airway drug transport studies

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903401511

A tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: skin irritation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903401511

A tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: eye irritation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903401511

Mechanistic assessment of peptide reactivity assay to predict skin allergens with Kathon CG isothiazolinones.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903401511

Skin sensitizers induce antioxidant response element dependent genes: application to the in vitro testing of the sensitization potential of chemicals

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903401511

Filling the concept with data: integrating data from different in vitro and in silico assays on skin sensitizers to explore the battery approach for animal-free skin sensitization testing

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903401511

Organ culture at the air-liquid interface maintains structural and functional integrities of inflammatory and fibrovascular cells of nasal polyps.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903401511

Comparative DNA microarray analysis of human monocyte derived dendritic cells and MUTZ-3 cells exposed to the moderate skin sensitizer cinnamaldehyde

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903401511

A European pharmaceutical company initiative challenging the regulatory requirement for acute toxicity studies in pharmaceutical drug development.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903401511

Dendritic cells and skin sensitization: biological roles and uses in hazard identification

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903401511

Responses of differentiated primary human lung epithelial cells to exposure to diesel exhaust at an air-liquid interface.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903401511

Dermal exposure to chemicals in the workplace: just how important is skin absorption?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903401511

Replacement of in vivo acute oral toxicity studies by in vitro cytotoxicity methods: opportunities, limits and regulatory status

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903401511

The international validation of a fixed-dose procedure as an alternative to the classical LD50 test

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903401511

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903401511

A critical review of the assessment of eye irritation potential using the Draize rabbit eye test

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408440903401511

10.3109/10408440903401511

21 January 2018

Identifiers

DOI

1 reference

22 August 2017

1 reference